Luigi Cirillo

A new Science study in mice provides insights into why females in their reproductive years appear to be relatively protected from chronic kidney disease, a leading public health concern. Learn more: scim.ag/3JO2DEC

Early CKD in young adults with congenital solitary kidney is often missed. Standard tests (eGFR, proteinuria, BP) can look normal. This study shows how renal scintigraphy helps detect silent damage. Better follow-up starts with better tools. Read: doi.org/10.1093/ndt/gf…

Our new study reporting anti-slit autoantibodies against podocin and Kirrel1 in a subset of patients with nephrotic syndrome is out in JASN journals.lww.com/jasn/citation/…

Anti-slit diaphragm antibodies on kidney biopsy identify pediatric patients with steroid-resistant nephrotic syndrome responsive to second-line immunosuppressants. doi.org/10.1016/j.kint… @UNI_FIRENZE @UniBarcelona @LMU_Muenchen #OpenAccess #pediatricnephrology #NephroticSyndrome

Another important hint from this study: when proteinuria is severe usually genetic or autoimmune podocytopathy. When <4 of P/C ratio these causes still possible but much less likely kidney-international.org/action/showPdf…

Proud to share our paper in @Kidney_Int! Excited to see our research on anti-slit antibodies in steroid-resistant nephrotic syndrome published—a significant step toward targeted treatments. Huge thanks to my mentor @PRomagnani and @AngelottiLucia. kidney-international.org/article/S0085-…

Four more important conclusions are: 1. The traditional lesion patterns MCD/FSGS are clinically unuseful to inform about how to treat, 2. More antigens exist, 3. Autoimmune, genetic and adaptive are the main DD, 4. Autoimmune podocytopathies have a good prognosis.

Look how much more important is to know if a patient is genetic or has anti-slit antibodies than if has MCD or FSGS at kidney biopsy. We have finally come to the era of autoimmune, genetic and adaptive podocytopathies. No more MCD or FSGS used as diagnosis!

Anti-slit antibodies define response to therapy and prognosis much better than histopathological lesion patterns even among patients with steroid-resistant nephrotic syndrome kidney-international.org/action/showPdf…

Our new study is out! By STED microscopy on kidney biopsy and ELISA assays we show 1/3 of pediatric and half of adult patients (more in primary FSGS) have autoantibodies against slit antigens different from nephrin. i.e. anti-slit Abs kidney-international.org/action/showPdf…

Our editorial on #exome first strategies in medicine is out in @NDTsocial Time to change perspective @cirluigi @fondazionemeyer @UNI_FIRENZE

There are so many things we talk about in medicine that seem like a complete waste of everybody's time. Anyway, I'm putting together a skit on contrast nephropathy should be out soon.

Proud to share our cover and editorial on green nephrology💚!! An amazing and collaborative effort by #ISN_ELP @Kidney_Int @ISNkidneycare Check it out 👇⬇️ authors.elsevier.com/a/1hHSTJOcprVeE

Our new work on Clostridium Septicum superinfection complicating #HUS just released in @JournalofNeph: rare among rare. @cirluigi @UNI_FIRENZE @fondazionemeyer link.springer.com/article/10.100…

Kidney stones and thiazide diuretics: Revisiting old assumptions in light of the NOSTONE trial ow.ly/MVXV30svy9Q @CKJsocial #openaccess #Urolithiasis #OpenAccess

Finally out! New proposed classification of glomerulonephritis focused on etiology, activity and chronicity to optimize patient management. ⁦@hjanders_hans⁩ ⁦⁦@KitchingLab⁩ and Nelson Leung academic.oup.com/ndt/advance-ar…

1/ ⏰ Tweetorial time! Before the weekend, let's check the recent review on CKD in children published by @CKJsocial. @letiziadechiara is a YNP member! academic.oup.com/ckj/advance-ar… Prepared by @iamnephrologist and @smirioglu on behalf of the @ynptweets of the @ERAkidney.

📢NEW Review: Chronic kidney disease in children: an update 🔓bit.ly/3LA0Hhs 📸Staging of CKD in children and adolescents 📸Causes of CKD in children and young adults and frequency of genetic forms 📸Mechanisms of CKD progression in children

Chronic kidney disease in children: an update ow.ly/P51A30sv2Ib @CKJsocial #openaccess #CKD

Just published in @ASNKidney360, our perspective reviews the experience of renal genetic clinics and offers sparks on how to integrate genomics in daily clinical practice in nephrology. @cirluigi