Colin Logie

7 resources and 100ds of papers were curated to catalogue 1,457 human genes that fit the Molecular Function ‘sequence-specific DNA binding transcription factor’.

@ValWood5 @bparsia Absolutely - to both sides. I have used GO enrichment and have encountered interesting, meaningful GO enrichment, and also I flinch whenever it arises in a talk or paper.

@GenomeBiology @stefanoceri Notice that the Tweeter of Genome Biology @GenomeBiology got it wrong? >< are not TAD boundaries. <>> and <<> are! The convergent sites ><< and >>< mark right-biased (-> ->) to left-biased (<-<-) interaction transitions! Simple is not easy, Elegant is not straightforward.

Nanni, @stefanoceri and @colinlog analyze clusters of CTCF sites, according to their orientation. Over the 5-100 kb range, divergent sites (eg <<>>) are enriched and convergent sites (>><<) are depleted. Convergent sites mark boundaries of TADs genomebiology.biomedcentral.com/articles/10.11…

Our paper on the CTCF site anatomy of Topologically Associating chromosome Domains (TADs) is out in the on-line journal Genome Biology rdcu.be/b6dya. #CTCF #3Dgenome

#CTCF# #3Dgenome#