Complex Portal

🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling. Explore RAS at the complex level → new therapeutic insights. #RAS #KRAS #RASopathies #CancerBiology #ComplexPortal

Now curated: • SHOC2-MRAS-PP1 phosphatase complexes (RAF activation; linked to RASopathies incl. Noonan-like syndromes) • KRAS/HRAS-SOS1 activation complexes • KRAS-RAF1 & KRAS/MRAS-PIK3CA effector complexes

🔬 𝑵𝒆𝒘! 𝐑𝐀𝐒 𝐬𝐢𝐠𝐧𝐚𝐥𝐥𝐢𝐧𝐠 𝐜𝐨𝐦𝐩𝐥𝐞𝐱𝐞𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐂𝐨𝐦𝐩𝐥𝐞𝐱 𝐏𝐨𝐫𝐭𝐚𝐥 RAS proteins function in multi-protein assemblies that drive MAPK & PI3K signalling.

Integrating resources like Complex Portal, MONDO, OMIM & EFO helps map diseases to complexes - a powerful lens for research and clinical insight. #RareDiseaseDay #ComplexPortal #MONDO #OMIM #EFO

🔬 Dynein complex variants (e.g. DYNC1H1) impair axonal transport → Charcot-Marie-Tooth disease (CMT). 🔥 STING gain-of-function variants hyperactivate interferon signalling → SAVI.

🌍 Rare Disease Day: When Molecular Complexes Break Rare diseases aren’t just “gene disorders” - many disrupt macromolecular complexes, the molecular machines that keep cells running.

Complex Portal release 252 is out! 5,296 manually curated biological complexes. ebi.ac.uk/complexportal/… (in sync with UniProt release 2026_01)

👩‍🔬 𝐒𝐨 𝐭𝐡𝐢𝐬 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫, let’s resolve not just to feel healthier, but to understand how our biology really works - guided by evidence, tools, and data that are openly accessible and citable. 🧠✨ #COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026

Explore key blood & circulation complexes: 1. 🩸 Haemoglobin 🔗 tinyurl.com/3rdhwk3h 2. 🧴 Cholesterol homeostasis 🔗 tinyurl.com/23hvtnzx 3. 🧪 Prothrombinase (coagulation) 🔗 tinyurl.com/34m7f5e7 4. 🛡 Complement C3/C5 convertases 🔗 tinyurl.com/mujtd345

🧬 New Year, new health goals - let’s get real: January brings exercise plans, diet fads, & oxygen therapies like hyperbaric chambers - all claiming to “cleanse” or energize your blood.

UniProt is taking part in the @EMBO Computational Structural Biology workshop in @EMBLHeidelberg from 2nd to 5th December. Conny Yu will be presenting poster 195 ‘UniProt as a central hub for structure-function analysis’. Visit the @EMBOComp3D webpage: embl.org/about/info/cou…

New ProteinSpotlight blog post Have you ever wondered where the feeling of thirst comes from? Discover how TMEM63B acts as an osmosensor deep in the brain to remind us to take a drink. Read the blog here: proteinspotlight.org/back_issues/28… @ISBSIB

From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology: “AI is showing how vital data curation really is.” ebi.ac.uk/about/news/per… #biocuration #FAIRdata

Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work for important open data resources including: @uniprot @complexportal @intact_project @news4go @InterProDB

Registration is free but essential: tinyurl.com/4v3jf4e9 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

Would you like to learn more about molecular interactions & to explore them across organisms? Join us next week for an introductory webinar where we walk through the IntAct's approach to molecular network modelling & show how this is implemented within the IntAct Cytoscape app.

Meet Jana Broecker 🇩🇪 who helps build bridges between EMBL-EBI and industry. As a Senior Scientific Officer in our Industry Partnerships team, Jana enables knowledge sharing and technology transfer, focusing on bioinformatics and data sciences. ebi.ac.uk/about/news/per…