Dagmar Iber

Are you a C++ expert and interested in making 3D cell-based tissue simulations with SimuCell3D ever more powerful? Please apply and join us as Master student, PhD student or Post-Doc!! jobs.ethz.ch/job/view/JOPG_… jobs.ethz.ch/job/view/JOPG_… x.com/DagmarIber/sta…

Preprint: doi.org/10.64898/2026.… Tweetorial: bsky.app/profile/iberd.…

What determines the sharpness of cell fate boundaries in gradient-based patterning? We quantified #transition #zone #widths (TZW) across seven progenitor domain boundaries spanning the entire dorsal-ventral axis of the developing #mouse #neural #tube. Links in next tweet.

The goal: make it easier for others to reproduce and extend these models within #COMSOL. We hope this serves as a generalisable reference for simulating collective cell behaviour and pattern formation. arxiv.org/pdf/2509.08930 Thx to @COMSOL_Inc for implementation support

This complements our earlier work introducing the #DCM model with focus on biological questions & mathematical framework 👉 bsky.app/profile/iber... Here, we focus on the practical #COMSOL #PIDE implementation: setup, BCs, 1D–3D & Lagrangian reformulation for growth.

Simulating Organogenesis in #COMSOL: Tissue Patterning with Directed Cell Migration 👉 detailed walkthrough of how to implement #DCM partial integro-differential equation models 👉 accessible simulations of tissue patterning and morphogenesis. arxiv.org/pdf/2509.08930

@briscoejames @AKicheva Great to see our paper "Morphogen gradients can convey position and time in growing tissues" now out in @NewtonCellPress cell.com/newton/fulltex…

It will be interesting to see in which developmental systems gradient-based timers are employed — and how they prove useful in #bioengineering efforts. Many thanks to Marius Almanstötter, Marcelo Boareto, @briscoejames, @AKicheva, José Dias & Johan Ericson for discussions!

How does an #embryo measure #time? It turns out that morphogen gradients can also act as timers. Check out our latest @biorxivpreprint : doi.org/10.1101/2023.0… #development #morphogen #patterning #preprint #cells #tissue 👇Thread 🧵(1/9)

• #DCM is a rapid, robust mechanism for developmental pattern formation • @COMSOL #FEM 1D, 2D, 3D implementation makes DCM models numerically accessible • DCM patterning parameter ranges and timeframes • Pattern Orientation via attraction anisotropy or directed tissue growth

Latest work from the group: #FEM @COMSOL implementation & analysis of #PDE model for Directed Cell Migration #DCM Preprint: doi.org/10.1101/2025.0… Tweetorial: bsky.app/profile/iberd.… #DevBio #PatternFormation #CellMigration #Morphogenesis #ComputationalBiology

Latest work from the group: #PINNverse — a game-changer for parameter estimation in differential equations! 🧠💡 Preprint: doi.org/10.48550/arXiv… Tweetorial: bsky.app/profile/iberd.… #SciComm #MachineLearning #InverseProblems #PINNs

Pleased to see our #mechanobiology paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer" now out @NaturePhysics : doi.org/10.1038/s41567… with News & Views "Tissue wrinkles foreshadow cancer" doi.org/10.1038/s41567…

@ETH Globe provides a #lay summary of our #bladder #cancer project: "A new direction for cancer research" ethz.ch/en/news-and-ev…

What role does tissue mechanics play at the onset of epithelial bladder cancer? Check out our latest #preprint biorxiv.org/content/10.110… #BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling 👇Thread 🧵(1/9)

🚨 We are thrilled to announce our amazing list of keynote speakers!! @PCusachs @GeorgHalder @hirashima0203 @dagmarIber @johannaivaska @gijsjekoenderi1 @neuroliege @renkawitzteam @Sixt_Lab @VickySanzMoreno Kit Parker @EdouardHannezo @creinhartking @WickstromLab @MEmilieTerret

Pleased to share our latest review "Coordination of nephrogenesis with branching of the urinary collecting system, the vasculature and the nervous system" authors.elsevier.com/a/1kXJ6Fzn7SUEy

Thoughtful perspective by Alexander Mietke on our recent work on #bladdercancer @naturephysics1 Tissue wrinkles foreshadow cancer nature.com/articles/s4156…

We present a simple yet comprehensive model integrating multiple mechanical forces to guide lung development. These principles operate during both development and disease, providing a dynamic framework to understand and predict lung remodeling processes.

In #COPD patients, destruction of #lung #tissue leads to #remodelling of the lung tree. Our biophysical model explains the thickening of the airway walls, potentially helping to localize affected areas, and yields quantitative #biomarkers for #PersonalizedHealth.

How does an #embryo build an energy-efficient #fractal #lung in time for the first breath at birth? 🫁 Discover the #mechanical forces shaping the bronchial tree in our latest preprint: doi.org/10.1101/2025.0… #LungDevelopment #Mechanobiology