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dan nolan
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dan nolan
@dannolan
semi-retired computer user
Sydney Katılım Mart 2007
3.5K Takip Edilen29.5K Takipçiler
dan nolan retweetledi
dan nolan retweetledi
How did a catfish get access to the clay model is what I’d love to know
Sir Chris McStill@SeasideChris
According to the Luce press pack, the nose design was a lucky accident. Jonny Ive’s pet catfish ate a chunk out of the clay model, and they liked it so much they kept it that way.
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Luther in-between Mission Impossible 3 and 5 :
Seth Vargas@ohsethy
What if… I became a new guy
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dan nolan retweetledi
In a large Texas cohort called ARIC, Jonathan Cohen found the lottery winners. A few hundred people whose PCSK9 gene carried loss-of-function mutations. Their LDL cholesterol was 28% lower than average, and their coronary heart disease risk was 88% lower. Published in NEJM in 2006.
These people hadn't done anything to earn it. A single gene was broken, and their livers ran a cholesterol-clearance program that the rest of us need daily medication to approximate. Most of them didn't even know.
We've spent 20 years approximating. Statins work, and roughly half of patients quit within 12 months. PCSK9 injectable antibodies work better, at $5,850 a year, with uptake rates so poor that cardiologists write papers about it.
Today @NEJM published a trial that stops approximating. VERVE-102 is a base editor. One IV infusion rewrites a single DNA letter in liver cells, shutting down PCSK9 the way it's already shut down in Cohen's lottery winners.
Heart-2 trial: 35 patients, six doses. The highest dose cut LDL 62% and suppressed PCSK9 protein 88%. Effects sustained 18 months and counting. No serious adverse events.
The gap between the people who won the genetic lottery and everyone else just got an engineering solution.
Crémieux@cremieuxrecueil
Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!
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dan nolan retweetledi
“It’s my honor to announce that the true pope is working with us from Avignon”
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You can tell that things are actually getting truly inexorably worse because in my day it was "artisanal avocado toast, lattes, and a dang eye phone" and for the zoomers its "mcdonalds"
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dan nolan retweetledi
dan nolan retweetledi
GitHub does this weekly.
Joe Cohen@CohenSite
I think the tech industry should fight back by doing "a day without data centers"
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dan nolan retweetledi
dan nolan retweetledi
@zetalyrae For me it’s the leakage of prompt description into product - the other day I saw a website with a header “high seo keyword header”
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To me, the AI tell is this font + text in all uppercase. For some reason LLMs love to scream at you "🔍 KEY FINDING" or "🚀 TEST RUN SUCCESS".
Mario Zechner@badlogicgames
if we see this, we know
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Ah great to see the Liberals think families purchasing top tier PHI policies, which are the only ones to include pregnancy and birth cover, deserve less government support than oldies on the same top tier policies
Senator the Hon. Michaelia Cash@SenatorCash
Labor is removing the higher private health insurance rebate for Australians over 65. Modelling from Private Healthcare Australia shows some retirees could face premium increases three times higher than younger members. A couple over 70 with gold hospital cover could be hit with an extra $1,614 a year. Over 900,000 of those affected earn less than $55,000. These are people who did the right thing and kept private cover to take pressure off the public system. Now they're being punished for it. Because when Labor runs out of money, they come after yours.
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@dannolan @gbrl_dick @mpopv @JesusFerna7026 has a good talk on this here: mercatus.org/macro-musings/…
Inflation affects everyone, even in a bad recession only a small % remain unemployed.
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@Potstirrer111 they could just walk it back too, keep it simple, the narrative is easy and cop a W but they won't, sad
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@Potstirrer111 couldn't have happened to a nicer group of guys - I frankly fucking hate property speculation because it's monumentally unproductive and crowds out investment in productive assets
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Because they were making absolute bank running Facebook ads and getting young guys to buy shitbox houses in regional towns and charging them 25k to do it. License to print money and now their gravy train is finished because the prices of the homes now won’t go up for their clients and the holding costs will be like 500 a week without negative gearing.
Albo broke their business model lol
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@gbrl_dick @mpopv I think it was J Pow who said (misquote) "We traded higher inflation for fewer job losses and realised people cared more about inflation than job losses" which I reckon is true
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dan nolan retweetledi
i'm glad more people are learning about the delightful naming conventions in civil forfeiture caselaw
Unfunny@unfunnymeat
court cases being called [blank] vs. [blank] is one of the hardest choices our political system has made
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