Danielle Debruin, PhD

New #NPJRegenMed paper: Myoblast-derived ADAMTS-like 2 promotes skeletal muscle regeneration after injury. tinyurl.com/ywrhzv79

JCI Insight - Spatial detection and consequences of nonrenal calcitriol production as assessed by targeted mass spectrometry imaging insight.jci.org/articles/view/…

New @biorxivpreprint Skeletal muscle PGC-1α remodels mitochondrial phospholipidome but does not alter energy efficiency for ATP synthesis biorxiv.org/content/10.110…

JCI - Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis jci.org/articles/view/…

Very glad to share the most recent publication from the ⁦@MuscleX_Lab⁩ at ⁦⁦@JPhysiol⁩ to show that fast skeletal muscle is optimized for rapid contractions, and the slow cardiac muscle is more finely tuned to allow for the cardiac reserve physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Exploratory physiological experiments are not clinical trials. Letter to the Editor at Cell Metabolism authors.elsevier.com/a/1i%7EWj5WXUl…

It was a long time coming - perseverance of @ddebruin9 finally rewarded #myotwitter. Debruin - JCSM Communications onlinelibrary.wiley.com/doi/full/10.10… @iHealthSportVU, @AIMSSresearch

Congrats to @ddebruin9 @alan_hayes_vu & Team for their new JCSM Comm paper "Combined orchiectomy & limb immobilization recapitulate early age-related changes to skeletal muscle in mice" that included the CMR's @CraigAGoodman1 @iHealthSportVU @AIMSSresearch onlinelibrary.wiley.com/doi/10.1002/rc…

RANKL signaling drives skeletal muscle into the oxidative profile | Journal of Bone and Mineral Research | Oxford Academic academic.oup.com/jbmr/advance-a…

Safety and efficacy of givinostat in boys with Duchenne muscular dystrophy (EPIDYS): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial - The Lancet Neurology thelancet.com/journals/laneu…

Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3: buff.ly/436wv4W @Med_UMinho #Neuroscience #Therapeutics

@JCI_insight @SantamariaUK

IRF5 governs macrophage adventitial infiltration to fuel abdominal aortic aneurysm formation: buff.ly/3UYy5Uv #VascularBiology

Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction physoc.onlinelibrary.wiley.com/doi/10.14814/p…

Muscle abnormalities worsen after post-exertional malaise in long COVID | Nature Communications nature.com/articles/s4146…

Clever bioinformatic + cell-based approaches by @XuZhang_Mayo and our @MayoClinic colleagues @MadisonDoolitt3, @skhosla78, + others to unravel how #senescent cells (FAPs) drive features of skeletal muscle #aging: @AgingCell onlinelibrary.wiley.com/doi/10.1111/ac… #sarcopenia

A festive treat here in Surrey! Dr. John Morser from @Stanford introducing the complex world of proteolytic regulation of osteopontin @BSMB1 @IntSocMatBio

Our latest effort published in @ExpPhysiol "High-fat diet effects on contractile performance of isolated mouse soleus and extensor digitorum longus when supplemented with high dose vitamin D" excellently led by @sharn_shelley physoc.onlinelibrary.wiley.com/doi/full/10.11… @CovUniResearch

Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation | Nature Communications nature.com/articles/s4146…

One of many excellent articles on extracellular vesicles in the most recent issue of @JPhysiol Exercise, healthy ageing, and the potential role of small extracellular vesicles - McIlvenna - 2023 - The Journal of Physiology - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/full/10.11…

People with obesity exhibit losses in muscle proteostasis that are partly improved by exercise training …iencejournals.onlinelibrary.wiley.com/doi/10.1002/pm…