DEEPTHI RAMESH

Workflow for E3 Ligase Ligand Validation for PROTAC Development | ACS Chemical Biology pubs.acs.org/doi/full/10.10…

Here are the ten approved HIV protease medicines. The first nine all used the same design strategy to address the flap water. The last took the alternate approach and replaced it. mcconnellsmedchem.com/2023/06/17/wha…

Celebrating new publication. We demonstrate novel #imidamide based linkage for attaching #smallmolecules based on #drugdesign principles to #chitosan. lnkd.in/gZhEq9b6 #polymer #biomaterial #Researchpaper #postdoc #Chemistry #biopolymer

DEL-Dock: Molecular Docking-Enabled Modeling of DNA-Encoded Libraries #MolecularDynamics pubs.acs.org/doi/10.1021/ac… @KShmilovich @Tkaraletsos Vol63 Issue9 #JCIM #compchem

Seeking postdoc position #polymer #medicinal #biomaterial #postdoc Please feel free to reach out if you have any inquiries or potential opportunities to discuss. vgbalaji.com scholar.google.com/citations?user… linkedin.com/in/dr-balaji-g… orcid.org/0000-0003-0126…

Incredibly useful "cheatsheet" on cancer chemotherapy classes. From Cell Press sciencedirect.com/science/articl…

Discovery of an Oral, Beyond-Rule-of-Five #Mcl-1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies pubs.acs.org/doi/10.1021/ac…

First woman possibly cured of HIV by transplanting HIV-resistant stem cells from umbilical cord blood. @persaud_deborah @UCLA Read more in @CellCellPress

Over the last 10 years, the #CRISPR toolbox and its applications have profoundly changed biological research, enabling advances through applications in plants, animals, and humans. A recent #ScienceReview highlights a decade of the technology: scim.ag/1py

Lipinski’s Rule of 5 has been highly influential in guiding Med Chem in the past 25 years. What does it offer for the next 25 years of drug discovery? @HartungIngo and colleagues provide answers here: nature.com/articles/s4157…

Researchers have discovered the first known "virovore," an organism that feeds on viruses. Probably there are many others like it -- an entire, previously unknown food chain. One day into 2023, and already things are going topsy turvy. eurekalert.org/news-releases/… #ecology #life

Here's the slide that took me 6 months to make. The six classes of molecular interactions for drug design. Clearly H-bonds are the first thing to master as a drug designer followed by pi-pi and sigma-sigma interactions.

This is in my eyes the most important annual paper for students preparing for a job interview in medicinal chemistry (or process chemistry): provides a great overview about representative drug structures, their targets & synthetic routes used. @ACSBioMed pubs.acs.org/doi/10.1021/ac…

PERSPECTIVE in Journal of Medicinal Chemistry- Mechanistic Insights for Drug Repurposing and the Design of Hybrid Drugs for Alzheimer’s Disease pubs.acs.org/doi/10.1021/ac… @Drug Repurposing @Repurposing @drug development @Alzheimer's disease @demnetia @ACSPublications

🔥 New advance article for RSC Chemical Biology! 🔥 Nathan W. Luedtke et al @mcgillu exploring [4 + 2] and [2 + 4] #cycloaddition reactions on single- and double-stranded DNA! #chembio #bioorthogonal 🧐Read the #OpenAccess article 👉ow.ly/gpAq50J8LaQ

Latest article: Chitosan with pendant (E)-5-((4-acetylphenyl) diazenyl)-6-aminouracil groups as synergetic antimicrobial agents doi.org/10.1039/D2TB00… @JMaterChem @RoySocChem @deepthiramesh92

The Stimulator of interferon genes (STING) is key to the innate immune system's response to pathogenic DNA. STING dimers in the ER change shape upon binding the secondary messanger cGAMP (green), and this allows them to oligomerize and move to the Golgi. #blender #b3d #sciart

Glad to have latest publication @Wiley @Arch_Pharm. lnkd.in/dG3gNmqA