Delgoffe Lab

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s4158…

"An army marches on its stomach" is true of the immune system, says @DelgoffeLab on @CBCQuirks, speaking about his and @DrAlok_np40's new @Nature study that found a single meal primes T cells to better fight infection and respond to cancer immunotherapy. cbc.ca/listen/live-ra…

Retatrutide phase 3 obesity trial just came out and the results are genuinely insane: - 28.3% bodyweight lost on 12mg over 80 weeks - 70.3 pounds on avg. or 31.9 kg - 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory) - 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients - 65.3% of 12mg patients dropped below the obesity BMI threshold - 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%) - significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP - no cardiac or liver signals Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.

Love seeing our grantees in action! 🔬 This week, @Becky_ABC caught up with Greg Delgoffe & Tullia Bruno at the University of Pittsburgh, chatted with early-career researchers, and toured Pitt’s new biomed research hub. Thanks for the great visit, @UPMCHillmanCC @PittTweet!

In this @nature study, researchers in the @DelgoffeLab at @PittTweet showed that the short-term nutritional state of an individual has marked effects on T cell #immunity. 🍎 Read more: go.nature.com/4efI3KF Tune into the discussion: bit.ly/3PCHwIK

As you may know, every year @OveracreLab and I ride tandem to raise money for cancer research at @UPMCHillmanCC. Imagine the power if all my followers even donated a few bucks! 100% of your deductible donation goes straight to research! haku.ly/f2a012d52c via @R2C_Cancer

So honored and excited to talk about our new study, published in @Nature, on the BBC! @bbcworldservice bbc.co.uk/programmes/w3c…

#researcherspotlight Dr. Alok Kumar @DrAlok_np40 from Prof. Greg M Delgoffe lab @DelgoffeLab at University of Pittsburgh @PittTweet talks about his work on "How Eating Affects Immunity: Post-Meal Lipids Boost T Cell Function and Cancer Therapy" @Nature biopatrika.com/academia/resea…

They did the meme!!!

@Kevin_McKernan Umm, he’s actually talking about the necessity of basic science. You don’t get innovations without doing the curiosity based discovery. That being said, the CSR and study sections are broken, but he’s arguing for MORE basic science!

Probably Craig Venters last interview. The people who drone on about the necessity of NIH “basic science” are the duds and dropouts of the class. It’s food stamps for the underachievers.

While we can't go wrong with either choice in the @sitcancer election, I want to highlight the leadership and vision of @RobertFerrisMD. A dedicated surgeon and cancer immunologist, Bob's contributions to the field are immense; we'd be lucky to have him at the helm of SITC.

Thanks to @smithsonianmag for highlighting our work in @Nature about postprandial control of immunity! smithsonianmag.com/smart-news/you…

@SantoshVardhana This is important; bravo for bringing it up. I don't understand where the vitriol comes from (like "who hurt you, dude?"). I tend to review papers, even if I don't agree, as a summary of a lot of work; if they respond to critiques with even more, then it's good enough for me.

I don’t post much anymore but thought I would take a moment to share my feelings on an issue that has been papered over by the negative impact that external forces have had on science and scientists: the toxicity of our own interactions within the scientific community. (1/10)

Nature research paper: Postprandial lipid metabolism durably enhances T cell immunity go.nature.com/3QQ4SuD

@MagarianBlander @Nature @CellCellPress Thank you!

@DelgoffeLab @Nature @CellCellPress Congratulations

The world is full of odd happenstances. On the same day our paper on postprandial metabolism dropped @Nature, my 1st grad student, Nicole, published her postdoc paper at @CellCellPress! An incredible tour de force studying proteostasis in T cell exhaustion cell.com/cell/fulltext/…

@RoychoudhuriLab Thanks! So, we thought this. And, if after all of the murkiness of that RCT is worked out and it ends up being solidly true, we think this could be a mechanism!

Congratulations on some fantastic work Greg et al! Do these findings help explain data from observational and recently a randomised control study suggesting that the time of infusion affects the efficacy of checkpoint inhibitor immunotherapy with anti-PD1 antibodies?

Can diet shape immunity? At University of Pittsburgh, Greg Delgoffe and team show T cells respond better after meals, likely boosted by higher protein production for faster activation. The experiment may pave way for better CAR T-cell therapy as engineered T-cells fight much effectively. nature.com/articles/d4158…

Thanks for the highlight and your support of the Delgoffe Lab!

Thanks to @sciam for highlighting our new @Nature paper in a Breaking News article! scientificamerican.com/article/what-y… (also now I want a burger)