The Deliverome Project

Today we're launching Deliverome Bio, a focused research organization tackling one of the biggest bottlenecks in medicine: getting therapeutics to tissues beyond the liver.

@philippzross @arjunrajlab 💯

@arjunrajlab I feel like this would be a good split for academic and non-profit philanthropically funded institutes (e.g. FROs)

Can someone start a journal called “Cell Atlases” so that the rest of the journals can go back to publishing interesting things?

@AaronBergman18 Good question! It turns out that, unless therapeutics have a handle like a surface protein to hang on to or have a physical system/depot for retention, they are quickly distributed through the vascular system (and end up in the liver).

@deliverome Lol maybe this is a dumb question but isn’t the answer frequently “inject it physically into the target tissue”

Today we're launching Deliverome Bio, a focused research organization tackling one of the biggest bottlenecks in medicine: getting therapeutics to tissues beyond the liver.

The @Deliverome has officially lifted off! I am thrilled that its founders chose IFP’s revitalized Launch Sequence to announce it to the world. AI is accelerating the design of new disease therapeutics, but we often can’t get those therapies to the cells where they are needed. @BobbyHollings and @beccajcarlson propose to generate the data necessary to overcome this critical bottleneck with the Deliverome Project. Different tissues have different surface proteins, and different surface proteins have varying abilities to pull therapeutic payloads into their host cell. Though there are more than 2,200 of these proteins, they are largely unexplored, with most drugs targeting only 11 of them. This limited targeting can lead to payloads being delivered to cells where they aren’t needed, resulting in negative side effects. The Deliverome Project will produce the necessary dataset to solve this problem by measuring which proteins are specific enough to target distinct tissues while also being capable of pulling cargo into the cells. And the data will be released openly in AI-ready formats, creating a public good for the benefit of humanity. Becca and Bobby are an incredibly smart and dynamic duo, and I am so excited to follow their progress. ifp.org/the-deliverome…

Join us: deliverome.org/careers More on the Deliverome Project: ifp.org/the-deliverome… Follow along: deliverome.org

Co-founded by @beccajcarlson and @BobbyHollings, together with @beckypferdehirt and @radialscience at the @AsteraInstitute.

New blog post: The third wave of American philanthropy Hundreds of billions of dollars in new philanthropic capital will soon become liquid. The OpenAI Foundation holds 26% of OpenAI, worth about $220B at today’s valuation. Anthropic’s seven co-founders have pledged to give away 80% of their wealth and have instituted the most aggressive donor matching program for employees in tech history. How much does this all add up to? And how meaningful is that in the context of philanthropy today? I was doing some simple napkin math to wrap my head around the scale of what’s coming, and radicalized myself in the process. I had dramatically underappreciated the scale of the philanthropic capital that’s about to become available and the corresponding gap in talent and organizations that will be needed to make the most of it. This piece aims to directionally sketch the scale of what’s coming, the gap in operational capacity needed to absorb it, and what we can do to fill it. (Link to full post in reply)

Coming soon 👀