The DiffUSE Project

Open data. Public logbooks. No waiting for publications. The DiffUSE Project is redesigning the structural biology pipeline from sample prep to modeling, all in the open. Meet DiffUSE: youtu.be/_DILlMou1GM?si…

The diffUSE project is expanding, both in people and in scope! We are incredibly lucky to have @stephanie_mul coming on board full-time to lead science across the project. Check out the awesome explainer video, and Stephanie's blog post going into more detail below 👇

Stay tuned for more soon, and check out the code here - github.com/diff-use/sampl…. We hope others will build off/contribute to this. Also, we are expanding this team - see job posting here diffuse.science/work-with-us/.

We observed a tradeoff: weak guidance improves fit to data without wrecking protein geometry. But strong guidance destroys the geometry. Interestingly, models differ a lot in how they handle this despite similar architectures.

Excited to share Sampleworks, part of the @diffUSEproject. It's a modular framework connecting structure predictors (Boltz-1/2, Protenix, RF3) to experimental data and guidance methods. Swap predictors or guidance methods. diffuse.science/posts/samplewo…

We're expanding our life sciences work through a new division Radial led by @beckypferdehirt as CEO. Becky be work closely w @PracheeAC @seemaychou to help lead experiments with infrastructure and approaches to funding, enabling, and publishing science 1/

Two great @statnews pieces by @ADeAngelis_bio and Brittany Trang on what we're building at Radial

Sound interesting? Apply to join our team: diffuse.science/work-with-us/

Watching the scientists we work w @ArcadiaScience and now @diffUSEproject feels like a glimpse into the future. Esp the trainees who didn’t even hesitate to share all their work openly. Worth a watch 👇

We’re expanding! Help us find hidden data on protein motion @diffUSEproject

Read more: diffuse.science/posts/expandin…

Big news! I’m joining @AsteraInstitute as CEO of Radial, their new life sciences division. How we fund, do, and build upon science has long needed an update. At Radial, we design, fund, and operate programs that tackle foundational scientific problems while simultaneously testing better ways to do science.

@seemaychou There's a missing middle in science funding: too unglamorous for journals, too ambitious for VC, too cross-functional for one lab. Radial CEO @beckypferdehirt on why she's building something new, starting with DiffUSE: beckypferdehirt.substack.com/p/why-im-joini…

Read more from @seemaychou here: asterainstitute.substack.com/p/announcing-r…

Radial.org is live! A new organization at @AsteraInstitute bringing together structural biologists, engineers, and ML scientists to redesign how we do science. @statnews has the story: statnews.com/2026/03/11/rad…

Can Molecular Dynamics simulations predict how diffuse scattering changes with ligand binding? Mike Wall's latest post shows encouraging results for Mac1 +/- ADPr -- differences are strong enough they might be observable in experiments. Read more: diffuse.science/post/shake-it-…

Tomorrow (2/27) 3 pm ET, DiffUSE Project Scientist Steve Meisburger presents "Diffuse Scattering Wars (Episode IV): A New Hope for Structural Biology" Learn how diffuse scattering could reveal what AI structure predictors are missing. Join here: chess.cornell.edu/science/chess-…

Update from the first few months at the Diffuse Project: building towards integrated methods, data, models, and encodings so the community can routinely use diffuse scattering in basic biology and drug discovery

Apply here! diffuse.science/careers/

The Diffuse Project is looking for an amazing Project Manager to help us achieve our goal of unlocking protein dynamics! Are you a scientist who naturally loves organization, coordination, problem solving and working with a diverse team of scientists & engineers?