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Edgar García
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Edgar García retweetledi
Edgar García retweetledi
Edgar García retweetledi
Edgar García retweetledi

A LEGENDARY Game 7 between the Raptors and 76ers in 2019!
Kawhi's game winner (41 PTS, 8 REB, 3 STL in G7) capped off an incredible series where he averaged 34.7 PPG, 9.9 RPG, and 1.3 SPG! The Raptors would go onto win their first NBA Championship 🏆
Watch GAME 7 Sunday between the Cavs/Pistons at 8pm/et on Prime 🍿
English
Edgar García retweetledi

Transmutar el dolor en bondad requiere fuerza. Ser inteligente sin volverte cínico requiere fuerza. Por eso para ser amable se requiere fuerza.
Dr. Linda Berman@LindaBerman4
Kindness is more important than wisdom, and the recognition of this is the beginning of wisdom. Theodore Isaac Rubin
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Edgar García retweetledi
Edgar García retweetledi

Importante étude montrant:
1. Une relation effet dose pour le methylphenidate dans le #TDAH. Plus on monte la dose, plus c'est efficace.
2. Un plateau au dessus de 45mg: monter au dessus ne sert plus à rien.
Bravo à @CorteseSamuele et son équipe!
thelancet.com/journals/lanps…

Français
Edgar García retweetledi
Edgar García retweetledi
Edgar García retweetledi
Edgar García retweetledi

Reducing depression to a single ‘serotonin deficiency’ narrative was always an oversimplification. But concluding from that that antidepressants do not work is scientifically inaccurate.
Major depressive disorder is a complex, heterogeneous condition involving neuroplasticity, inflammatory pathways, stress circuitry, glutamatergic signaling, genetics, endocrine systems, sleep regulation, cognition, and psychosocial factors, not serotonin alone
SSRIs and other antidepressants continue to be prescribed because multiple large meta-analyses, randomized controlled trials, relapse-prevention studies, and real-world data consistently demonstrate efficacy, especially in moderate-to-severe depressioN
A mechanism being incomplete does not invalidate a treatment’s effectivenes
Aspirin worked before prostaglandins were fully understood. Lithium works despite mechanisms still being actively studied. Psychiatry — like all medicine — evolves beyond simplistic models
The Moncrieff paper questioned an oversimplified public narrative, not the entire evidence base for antidepressant efficacy
Enjoy the references:
Cipriani A, et al. Lancet. 2018;391:1357–1366.
Stahl SM. Stahl’s Essential Psychopharmacology. 5th ed.
Krystal JH, et al. Cell. 2020;181:484–503.
Otte C, et al. Nat Rev Dis Primers. 2016;2:16065.
Daly EJ, et al. JAMA Psychiatry. 2018;75:139–148.
Enjoy the poster

English
Edgar García retweetledi
Edgar García retweetledi
Edgar García retweetledi

@ElAripiprazol Este tema es algo que he pensado desde hace un buen de tiempo...
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New paper online! How does plasticity at specific synapses drive specific forms of learning? Learning extradimensional rule shifts depends on strengthening long-range GABAergic projections from parvalbumin neurons to PFC-MD neurons in the contralateral PFC cell.com/neuron/fulltex…
English
Edgar García retweetledi
Edgar García retweetledi

溶媒に汎用されるDMSOがBlastoid形成を誘導する驚きの報告。3%DMSOでヒトナイーブ幹細胞から内腔をもつBlastoid形成率が最大87%まで向上。DMSO→膜物性変化/TE分化を促進→V-ATPase上昇→内腔形成効率向上というモデル。DMSOがTE分化促進する直接機構は未解明。CellRes誌
nature.com/articles/s4142…
日本語
Edgar García retweetledi

A veces la raiz intelectual no es suficiente pero es un paso. Necesitas una experiencia.
𝓲𝓬𝓮@be_like_ice
Therapy as a Neurodivergent person is insane cause ive prepared a 10 page thesis on the intellectual roots of my feelings just for my therapist to ask "where do you feel it in your body??"
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