Dr. Pat Soon-Shiong

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Dr. Pat Soon-Shiong

Dr. Pat Soon-Shiong

@DrPatrick

Chairman of Chan Soon-Shiong Family Foundation, Exec Chairman ImmunityBio, Chairman and Chief Executive Officer of Los Angeles Times Media Group (LATMG)

Los Angeles Katılım Eylül 2009
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
So this randomized study says it all. If patients fail chemo and Keytruda then adding more Keytruda or more chemo does not extend survival… 5 months is what this randomized trials show. Patients with lung cancer who failed all standards of care deserve a chance to live longer with a high quality of life. Science matters. pmc.ncbi.nlm.nih.gov/articles/PMC93…
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
In the commentary of this randomized study by Jung, the commentators highlight: "Searching for Synergy: Chemotherapy and Checkpoint Inhibitors: Continuation of programmed cell death protein 1 (PD-1) inhibitors in combination with chemotherapy did not improve clinical outcomes for patients with non–small cell lung cancer who progressed on prior PD-1/programmed death ligand 1 inhibitor monotherapy. This highlights the need to evaluate the precise mechanisms of resistance to PD-1 axis inhibitors and explore alternative therapeutic strategies to overcome resistance." pmc.ncbi.nlm.nih.gov/articles/PMC93… ResQ201A (NCT06745908), the randomized Phase 3 trial is in motion to confirm the findings of QUILT-3.055 and address the search to prolonging survival after checkpoint failure. Enrollment progressing on a global basis. clinicaltrials.gov/study/NCT06745…
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
Saudi FDA understood the data and the importance of this finding.
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
So this randomized study says it all. If patients fail chemo and Keytruda then adding more Keytruda or more chemo does not extend survival… 5 months is what this randomized trials show. Patients with lung cancer who failed all standards of care deserve a chance to live longer with a high quality of life. Science matters. pmc.ncbi.nlm.nih.gov/articles/PMC93…
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
As we feared. The world and the global leadership need to address this non-infectious pandemic called cancer. Immunotherapy and cell therapy at scale is a response that is needed. Global scale. washingtonpost.com/health/2026/07…
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
Now home from my trip to UK and received this beautiful video from my patient. What an amazing and fitting song for our 250th anniversary of our great nation, Happy 4th to all. Billy is an inspiration to all of us for his strength and courage. His album coming soon. Stay tuned.
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
Congrats. Important work as we deconvolute ( if there is such a word) the complex immune system in our war against cancer. Well done
Ella Marushchenko@Ella_Maru

My cover is in Nature Immunology! Yeeey🔬✨ Two types of immune cells live inside tumors: they look alike but behave completely differently. 🫯One stays alert and fights. 🚨The other gets worn out from constant stimulation and stops working. This research finally told them apart, and showed why cancer therapy needs to target each one differently: doi.org/10.1038/s41590… So proud of this cover, and huge congratulations to @LMackayLab and @TheDohertyInst ! 💙

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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
Interesting .. Imagine a “Blank piece of paper” as Lou dreams about. See the mind map we drew in 2016! Congrats on this effort by Lou. Bipartisan funding push to cure deadly disease | The Point youtu.be/Vv2qHBokwWA?si… via @YouTube
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
The complex robot arm that is taught where and when to handle our NK cells as these cells grow in this revolutionary machine! Assembly on track. The world bank of NK cells made available to all ..global expansion in motion.
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
AI DRIVEN ROBOT IN ASSEMBLY IN LOS ANGELES! This will change the speed and scale of cell therapy
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
The future of targeting any protein in the human body. AI driven identification of these unique camelid nanobodies coming soon from NantBio. NantSearch - The AI driven antibody search engine for diverse "Nantibodies". The power of evolution. Watch this video for a basic understanding of Nanobodies youtube.com/watch?v=p1nrzE…
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YouTube
Dr. Pat Soon-Shiong@DrPatrick

So here we go …the year of the fire horse and reveal of 15 years of exciting execution of ..”imagine if ….” Over the next few months I will reveal the breakthrough technologies we have been developing in stealth mode at NANTWORKS ( over a dozen privately funded companies with over a billion dollars ) that may impact how we live, work and play. Some will involve healthcare, some climate change and others deep AI. Many will act synergistically with each company in helping us address life threatening and chronic diseases such as cancer, sepsis, auto immune diseases, diabetes. Deconstructing and activating every component of the immune system. The time has come in the year of the fire horse to unveil! Stay tuned. Today it was NantPhotonics to move data at the speed of light and drive AI for un-imaginable discovery at light speed. Imagine if we re-considered how Antibodies work and used AI to target every expressed and even intra cellular protein ? Then allow NK and T cells do their work? Stay tuned

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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
The data continues to accumulate that ALC matters. The NK and T cells in the tumor microenvironment completely correlates with survival. Our lung trials are being written to address this. cancernetwork.com/view/journal-t…
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
An important paper in the next chapter of orchestrating the complex machinery of our immune system is the B cell and the immense diversity of antibodies. The paper describing this next step will be published in June and I will then commentate dots as to why IL-15 is the backbone to this orchestration..from NK cells, to T cells, to memory T cells and now to B cells and memory Antibodies. The Nant quest of understanding the complex immune system ..30+ years and still learning!
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
The next evolution of Antibody drug development is happening. Spent the last week getting a deep insight and what I see together with AI modelling is stunning.
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Dr. Pat Soon-Shiong
Dr. Pat Soon-Shiong@DrPatrick·
As I scan the literature, I continue to be amazed of how far back the realization that the immune system matters regardless of the tumor type and that with loss of T and NK cells, survival is so significantly reduced. Here is a paper since 2012 that states, "These patients could be proposed for specific treatment approaches, including innovative strategies for immune restoration." Just imagine if such an approach was available. sciencedirect.com/science/articl…
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