Dr. Pat Soon-Shiong

As far back as 2019, Richard Pazdur, then head of OCE at FDA, recognized the importance of lymphocyte count in progression free survival and overall survival in lung cancer. I just discovered this paper today, just as I recently discovered the 2007 NCI workshop report showing the importance of T cell growth factor. He concludes that "baseline LDH level and dNLR are important prognostic biomarkers irrespective of treatment modality for patients with mNSCLC" meaning that whether the patient receives radiation, chemo, or checkpoint inhibitors, the level of lymphocyte count (ALC) is the critical biomarker for outcomes regardless of treatment modality. The Saudi FDA recognized this immediately and on that basis approved Anktiva for the treatment of 2nd line lung cancer who relapsed following standard of care. Pazdur further states "As further prospective clinical trial information is collected, the role of the LIPI score can be better defined." Stay tuned.

Beginning the campaign at Nant of identifying which outside technologies are being developed by innovative biotechs that could serve as synergistic elements to NK and T cell proliferation with IL15 stimulation. How could we change radiation ? How could we awaken dormant receptors from tumors? How could we change antibody design? All interacting with NK cells. Immunotherapy 2.0 on the march. Unstoppable.

Just learnt of this session. Important issues facing patients with papillary disease bladder cancer and patients facing shortage of BCG. These are the issues I have been discussing with FDA for a long time and will address them at our AUA talk on Saturday. Will livestream and share the presentation thereafter. Stay tuned.

Looking forward to presenting at AUA soon. Chemotherapy induces lymphopenia with increases in recurrence rates in bladder cancer, while BCG is an established immunotherapy. We need to fix the 14 year BCG shortage situation and it’s not through an alternative of more chemo which even results in fatality from the chemo. It’s to find alternative BCG. Stay tuned.

Had to repost this paper that the FDA knew and even published a report that patients with lung cancer who failed all standards of care die early because of lymphopenia. When T cell and NK cell count is increased progression is delayed and overall survival increases. Stay tuned.

The complexity of an AI driven robot that needs to meet GMP standards & learn complex steps of targeted cell manufacture. A marvel and the first robot of its kind in the world. Can’t wait till we lift off the first patient’s NK cells in LA from NANT LEONARDO. Unstoppable scale.

Almost there! We will transform cell therapy at scale. Beautifully made robot

The year of the fire horse. Now in Italy and inspecting our Ai driven robot nearing completion and a stainless steel horse in the lobby. A good sign of what is to come!! World Bank of NK cells.

Turkey is an amazing country with such enthusiasm. Global expansion happening!

Half of Patients With Advanced Lung Cancer Don’t Get Treatment, Study Finds nytimes.com/2026/05/07/wel… via @NYTimes “About 40 percent of patients in the new study died within three months of their lung cancer diagnosis. Many of them were probably just “too sick to get treatment by the time their tumors were found,” said Dr. Gerard Silvestri, a pulmonologist at the Medical University of South Carolina and the senior author of the study.” Chemo. Radiation then checkpoints, then even more chemo!! When do we learn that this can change with immunotherapy? What could we do for the thousands of patients who failed all of above? Quilt 3005 now approved by Saudi FDA .

Amazing visit to Greece where I met with the Prime Minister @PrimeministerGR, the Minister of Health @AdonisGeorgiadi and also received a wonderful blessing from His All-Holiness Ecumenical Patriarch Bartholomew I. NK cells are God's gift to humanity and Greece has embraced this for their people. Global expansion continues.

I spent my early career on diabetes. Next was understanding the beauty of Albumin and so came Abraxane. Now Glip-1. Will begin to connect the dots for diabetes soon. Albunext coming! See NYT: We’re at the Dawn of the Ozempic Era — and It’s Really Weird nytimes.com/2026/05/08/opi… via @NYTOpinion

In the land of Hippocrates the Father of Modern Medicine..do no harm. The Acropolis in the background.

A Phase 1 trial of NK-92 cells for refractory lymphoma and multiple myeloma almost a decade ago shows safety and evidence of efficacy with 2 complete responses. Will begin a trial of Anktiva combined with targeted cell therapy. Power of NK and T! pmc.ncbi.nlm.nih.gov/articles/PMC56…

The WORLD’S FIRST NK CELL MANUFACTURING ROBOT IN PRODUCTION ! Machine learning at its best. AI driven manufacturing. Delivery this month.

Biology is AI. The understanding of the LEGO blocks at the amino acid level will unlock the cures we have all been waiting for. From amino acid to peptides to proteins and how to shape shift the proteins into cytokines, antibodies and target them to our biological needs. Spent 30 years understanding this from Abraxane to shape shift the most dominant protein in our body- Albumin, to Anktiva the most important cytokine in our body. Next antibodies. More to come and the world of biology is finally being unravelled. Nice talk. Should watch. x.com/alc2022/status…

Global expansion. Unstoppable

So the Thymus produces T cells. IL-15 is a T cell growth factor. When the Thymus is removed, there is a 2x higher chance of dying earlier of all causes according to this report. These findings are consistent with the JAMA paper that shows when ALC is less than 1,500 (low T cells) longevity is decreased with increased mortality risk from all causes. The data is consistent: IL-15 is a T cell growth factor and they called T cells because of the T in Thymus. And IL-15 was ranked #1 by NCI and FDA to "cure" cancer as far back as 2007. Now this report links the Thymus (which produces T cells) to longevity - consistent with the JAMA report that 52 million Americans suffer from low T cells, called lymphopenia. IL-15 to treat cancer, enable longevity and to overcome sepsis - Immunotherapy 2.0. Stay tuned. Are the dots connecting that ALC matters? JAMA Zidar 2019: "Association of Lymphopenia With Risk of Mortality Among Adults in the US General Population" jamanetwork.com/journals/jaman… WaPo Gift Link: "The body's most mysterious organ may play a key role in longevity and cancer. What to know about the incredible shrinking thymus"

The FDA is on the HUNT for promising therapies.

From ⁦@latimes⁩ latimes.com/world-nation/l…