Dr. Pat Soon-Shiong

As we feared. The world and the global leadership need to address this non-infectious pandemic called cancer. Immunotherapy and cell therapy at scale is a response that is needed. Global scale. washingtonpost.com/health/2026/07…

Now home from my trip to UK and received this beautiful video from my patient. What an amazing and fitting song for our 250th anniversary of our great nation, Happy 4th to all. Billy is an inspiration to all of us for his strength and courage. His album coming soon. Stay tuned.

Congrats. Important work as we deconvolute ( if there is such a word) the complex immune system in our war against cancer. Well done

Thanks So important to understand the “ quantum” nature of the immune system and how finely tuned our bodies are to fight cancer.

Interesting .. Imagine a “Blank piece of paper” as Lou dreams about. See the mind map we drew in 2016! Congrats on this effort by Lou. Bipartisan funding push to cure deadly disease | The Point youtu.be/Vv2qHBokwWA?si… via @YouTube

The complex robot arm that is taught where and when to handle our NK cells as these cells grow in this revolutionary machine! Assembly on track. The world bank of NK cells made available to all ..global expansion in motion.

So excited to expand our voice at the NYSE! What a great partnership

The innards

Happening

AI DRIVEN ROBOT IN ASSEMBLY IN LOS ANGELES! This will change the speed and scale of cell therapy

The future of targeting any protein in the human body. AI driven identification of these unique camelid nanobodies coming soon from NantBio. NantSearch - The AI driven antibody search engine for diverse "Nantibodies". The power of evolution. Watch this video for a basic understanding of Nanobodies youtube.com/watch?v=p1nrzE…

The data continues to accumulate that ALC matters. The NK and T cells in the tumor microenvironment completely correlates with survival. Our lung trials are being written to address this. cancernetwork.com/view/journal-t…

An important paper in the next chapter of orchestrating the complex machinery of our immune system is the B cell and the immense diversity of antibodies. The paper describing this next step will be published in June and I will then commentate dots as to why IL-15 is the backbone to this orchestration..from NK cells, to T cells, to memory T cells and now to B cells and memory Antibodies. The Nant quest of understanding the complex immune system ..30+ years and still learning!

The next evolution of Antibody drug development is happening. Spent the last week getting a deep insight and what I see together with AI modelling is stunning.

As I scan the literature, I continue to be amazed of how far back the realization that the immune system matters regardless of the tumor type and that with loss of T and NK cells, survival is so significantly reduced. Here is a paper since 2012 that states, "These patients could be proposed for specific treatment approaches, including innovative strategies for immune restoration." Just imagine if such an approach was available. sciencedirect.com/science/articl…

On with @ChrisCuomo soon. @AfricaCDC Leadership under Dr. Jean Kaseya is being highly proactive both in Congo and Uganda to address this crisis and patients with severe illness. Will discuss a universal finding of immune collapse with ebola and sepsis. @NewsNation

Had a great discussion with @AfricaCDC and @MWayengera. Clinicians and scientists must come together to resolve this crisis. Discussing this with @ChrisCuomo today. Africa CDC is taking leadership in addressing Ebola crisis as urgently as they can. Agree this is what is called leadership.

Connecting the scientific dots. Please note that we are in the planning clinical trial stages to address lymphopenia and it IS NOT APPROVED as a therapy. IL-15 is the molecule we are discussing here. So connecting the dots: 1. 2007 workshop by NCI ranking IL15 as the number one ranked molecule since it is a T CELL GROWTH FACTOR. sitc.sitcancer.org/news/nci_manus… 2. When you age, or when you have infection or cancer your T cells decrease, sometimes to dangerous levels... that’s called lymphopenia. 3. The diagnosis of lymphopenia is EASILY made with a routine blood test performed millions of times everywhere in the world with what is called a CBC differential and the measurement is the “Absolute Lymphocyte count” or ALC 4. Zidar et al., 2019 (JAMA) including authors from Cleveland Clinic, Duke, Case Western reported that 20% suffer from Lymphopenia. Worse, these authors showed ~2x higher probably of dying earlier when you have severe lymphopenia... dying from what they report as “all causes” jamanetwork.com/journals/jaman… 5. Today I receive a paper in press 28 May 2026 entitled "First-week absolute lymphocyte count dynamics and 28-day mortality in older adults with sepsis". The author's stated, "Sepsis is now understood not only as hyper inflammation but also as a state of prolonged immunosuppression." link.springer.com/article/10.118… Amazing and timely paper. I do not know these authors but I look forward to meeting them. It seems that doctors in Turkey get it and clinical trials are needed to confirm that treating lymphopenia could reduce mortality. 6. I must emphasize that to date, there is NO drug approved to treat lymphopenia and our goal is to initiate clinical trials to confirm the hypothesis that by treating lymphopenia we have the potential to improve mortality in patients with sepsis. The results of increased mortality in the findings reported in today's paper are striking. Imagine the cost savings if we could reduce the ICU and hospital length of stay. Table 6 shows 10 days more in the ICU with lymphopenia and 12 days more in the hospital with significant increase of death in Figure 3

So here’s a clue From Nanobodies to Nantibodies. The goal: ADCC and ADCP I know that’s a foreign language but I’m sure many will figure that out..the future of antibody targeting