Ellen Tsai

1/10 Large eQTL resources enable identification of genes for which cis-eQTL effects colocalize with GWAS hits. We are happy to announce that our MetaBrain study and eQTL resource is now out at Nature Genetics (nature.com/articles/s4158…).

Our paper on rare variant associations in the UK Biobank is out in Cell Genomics today! cell.com/cell-genomics/…

New preprint led by Jamie Robinson, @tomrgaunt, @oldz84! Privileged to be on the team with my Biogen colleagues @YunFengHuang618, @denis_baird, @eatsai. An efficient and robust tool for colocalisation: Pair-wise Conditional and Colocalisation (PWCoCo) biorxiv.org/content/10.110…

Genetic associations affecting gene expression are often dependent on unknown (biological) context. In our latest preprint, we introduce PICALO: a method that identifies hidden eQTL contexts that we refer to as Principal Interaction Components (PICs). biorxiv.org/content/10.110… 1/8

New preprint! We studied how rare protein-coding variants impact cognitive function & linked diseases in @uk_biobank. We identified 8 large-effect cog fx genes, dosage-sensitivity for KDM5B, additivity of rare variant and polygenic risk & more (1/12) medrxiv.org/content/10.110…

Excited to share our new preprint: the first exome study of muscle strength in the adult population. We linked rare protein-coding variant information to hand grip strength (HGS) data in @uk_biobank, identifying 6 muscle strength genes & more (1/6) medrxiv.org/cgi/content/sh…

Very excited that our joint @FinnGen_FI+@uk_biobank coding variant #research is out with @SpringerNature in @Nature. Rare & common disease genetics, >650k, >700 diseases, lots of cool insights. More to follow! rdcu.be/cHCMs nature.com/articles/s4158…

Really great to see our GWAS in #ALS #MND now published in @NatureGenet. A huge collaboration with researchers around the World, including ~30K ALS patients. See open access publication here: nature.com/articles/s4158….

We're thrilled to release a manuscript on rare variant association testing on the exomes of 300k individuals in the UK Biobank medrxiv.org/content/10.110… and a browser of the results: genebass.org

Delighted to share our latest preprint: the largest analysis assessing the contribution of rare genetic variants to the risk of depression, based on the exomes from 320,356 @uk_biobank participants medrxiv.org/content/10.110…

Great to see the preprint of our ALS GWAS out on medRxiv: disq.us/t/3vjvhgx. Here's a quick summary:

Check out @Biogen at #ASHG19 career fair: we're building a strong team to leverage & move beyond genetics towards the treatment of devastating brain, muscle and eye diseases

This is amazing #marchforscience

There were so many good dogs at the #MarchforScience, we can’t pick a favorite trib.al/iPrY9Wu

@lisanwang Things are so bad, other countries have to march for us #marchforscience twitter.com/CNNPolitics/st…

Here's what it was like at the #MarchForScience scifri.me/c01

#marchforscience #standupforscience

#marchforscience #standupforscience

@lurkhash hi mness!! let's go hiking sometime ^^

Searches for "how can I move to Canada" on Google have spiked +350% in the past four hours #SuperTuesday