Edgar Miller

@davidwdowdy Great advice David. Our KL2 selection committee critiques of applicants aligns with your observations

After sitting in study section last week reviewing proposals for K-series career development awards, thought I'd list my top 5 reasons why such proposals fail. (Not linked to any one submission.) Junior scientists who might be interested in applying - avoid these pitfalls!!

@DrDeidraCrews great chat on vitamins thanks for viewing

Yes - big research needs. We know from trials that supplements do not lower your risk of dementia, cardiovascular disease or death - testing whether they make you feel better, better skin, hair,... would need to be tested in placebo-controlled randomized trials.

Recent meta-analysis 2017 in JAMA. "In this meta-analysis of randomized clinical trials, the use of supplements that included calcium, vitamin D, or both compared with placebo or no treatment was not associated with a lower risk of fractures among community-dwelling older adults"

Agree - eat less, move more, and rely on healthy food choices for disease prevention. If taking a multivitamin is a way to remember this every day, then probably ok to take - but don't count on the supplement to confer health benefits

Large randomized placebo controlled trials (where confounders are equally distributed in both arm) -best way to determine health benefits. Putting those trials together in meta-analyses have found no evidence to support antioxidant supplements for disease prevention #vitaminchat