@RadioP1 @Rainmaker1973 Enamel is dead tissue, so it can't "grow." But TRG-035 targets the actual bone bud. It’s not a joke.
English
James Evans
301 posts
James Evans
@evans_strengthx
Dased in Brno, chasing strength and calm in equal measure + obsessed with functional conditioning and long mountain runs 🏃♂️💪
Brno Katılım Eylül 2025
124 Takip Edilen34 Takipçiler
@Rainmaker1973 This LOOKS like an April fools joke, but I know a lot of work has gone into tooth enamel re-growth. So, I'm saying no to outright tooth regeneration, but yes to other enamel re-growth.
English
@XDAYSolis @Rainmaker1973 ngl it’s not just a "paper" anymore.Toregem BioPharma's human trials for TRG-035 started at Kyoto University Hospital in late 2024.We’re finally moving from mice to actual people.
English
@Rainmaker1973 This news has been on the Internet for 4-5 years, and the best dental clinics in America still do not have such technologies. Then what's the point of talking about something that doesn't exist?
English
@HukijuHacks @Rainmaker1973 man everyone’s obsessed with Ozempic, but a drug that regrows teeth is the real 21st-century flex.Toregem isn't just fixing smiles; they're making the entire multibillion-dollar dental implant industry look like the Stone Age
English
@Rainmaker1973 Did you know Dr. Takahashi launched Toregem BioPharma in 2020 just to commercialize this tooth regrowth technology? Fast forward to 2025 and they already scored orphan drug designation for congenital tooth loss cases.
English
@Rainmaker1973 dentists are going to hate this, but implants and dentures are officially on the clock. why pay thousands for a screw in your jaw when you can just regrow the real thing with an injection?
English
human trials for the tooth regrowth drug are officially moving into phase 2.
targeting the USAG-1 protein to wake up dormant "tooth buds" is some straight up sci-fi medicine.if this works, the "third set of teeth" is real.
Massimo@Rainmaker1973
A Japanese research team has developed a drug that can regrow human teeth. TRG-035, which works by blocking a protein called USAG-1 that prevents new teeth from growing. After successful trials in mice and ferrets, human clinical trials began in 2025.
English
@aakashgupta perplexity just turned a $129 turbotax session into a button. tax prep has always been about monetizing confusion, and an ai that actually navigates the forms for you is the ultimate disruptor.
English
Intuit generated $4.9 billion from its Consumer Group last year. Their fastest-growing product was TurboTax Live, up 47% to $2 billion in revenue, where you pay $89 to $129 for a human to walk you through forms the IRS designed to be confusing in the first place.
Perplexity just turned that into a button.
The tax prep industry has survived every technological shift for the same reason: the complexity is the product. H&R Block, TurboTax, Jackson Hewitt, CPAs charging $300/hr. They all monetize the gap between what the IRS requires and what a normal person can understand. The entire $14 billion tax prep market exists because the U.S. government won't pre-fill your return like 36 other countries already do.
An agentic AI that can navigate the IRS website, pull your forms, and walk you through each line item collapses that gap to zero. The $20/month Perplexity subscription that also answers your questions, writes your emails, and browses the web now includes the core function of a $129 TurboTax product.
TurboTax's response tells you they see it coming. They opened 600 local service centers and 20 new retail locations this year. The largest online tax prep company in America is building physical offices. That's the play when you know your software moat is evaporating: sell the human, because the AI can replicate the software but can't sit across a desk from you.
The 160 million Americans filing returns this month are the last generation that will think of tax prep as a product you buy separately.
Perplexity@perplexity_ai
Perplexity Computer can now help prepare your federal tax return. Select “Navigate my taxes” on Computer to give it a shot.
English
The data on this is wild. Increased brain bioenergetics for 9 hours.
better performance even when sleep deprived. It’s not just for gains anymore.
Nicolas Hulscher, MPH@NicHulscher
A SINGLE 20g dose of creatine increases cognitive processing speed by 24.5% within 3.5 hours. A placebo-controlled trial found that creatine rapidly enhanced brain bioenergetics and improved cognitive performance during sleep deprivation, with effects lasting up to nine hours.
English
@NicHulscher forget the gym. creatine is a cognitive performance drug and most people are still treating it like a bicep supplement.
English
A SINGLE 20g dose of creatine increases cognitive processing speed by 24.5% within 3.5 hours.
A placebo-controlled trial found that creatine rapidly enhanced brain bioenergetics and improved cognitive performance during sleep deprivation, with effects lasting up to nine hours.
English
@piyascode9 man perplexity Perplexity is a fucking powerhouse researcher. idk while other AIs hallucinate facts, Perplexity gives you the receipts with clickable citations for every single sentence.
English
🧵 ChatGPT vs Grok vs Gemini vs Claude vs Perplexity — 5 leading AI tools explained.
Best use cases, strengths & pro tips.
No hype, just practical insights to choose the right tool.
📌 Save this post & read the full thread 👇
English
@SauceShuttle @Rainmaker1973 everyone thinks palliative care is the villain, but the real enemy is the "sick care" model.we wait until people are terminal to spend the most money.preventive care isn't just about health; it's a structural economic reset that actually lets us keep our tax dollars.
English
@Rainmaker1973 Palliative care going the way of the dodo in favor of preventive care is going to revolutionize our entire economic system. Why? Because it drastically reduces our highest monetary burdens. Healthcare costs have absolutely crippled U.S. taxpayers.
English
Swedish scientists develop microscopic nanobots that could prevent heart attacks without surgery.
These microscopic machines move through blood vessels, locate hardened buildup, and break it apart with incredible precision — restoring blood flow without the need for stents, surgery, or long recovery times. Early trials show that the nanobots can clean arteries far more effectively than today’s procedures, offering a powerful new option for preventing heart attacks and strokes.
The technology works by steering the bots with magnetic fields, guiding them directly to blockages that normally require invasive interventions. Once in place, the nanobots gently break the plaque into particles small enough for the body to process naturally, leaving the artery smooth and open. Patients in initial tests saw improved circulation almost instantly, proving just how transformative this approach could be for cardiovascular care.
But the breakthrough has sparked controversy in the United States, where cardiologists perform millions of repeat procedures each year to manage plaque buildup. Critics say the adoption of nanobot treatments could dramatically reduce the need for costly surgeries, cutting into billions of dollars in annual revenue from angioplasty, stent replacements, and other recurring interventions. Supporters argue that patient health should come first — and that technology capable of cleaning arteries in minutes should be embraced, not resisted.
English
@mahonj @Rainmaker1973 what if a bad actor hacks your nanobots?"your heart has been encrypted. pay 2 BTC to unlock blood flow." it sounds like a movie plot until you realize everything is networked now.
English
@Rainmaker1973 a: it is April 1st.
b: what is some bad actor hacks your nanobots.
c: How do they get them all out again..
d: What could possibly go wrong?
English
@Rainmaker1973 why are we still cutting people open when we have magnetic nanobots? oh right, because hospital boards can't buy yachts off a one-time nanobot treatment. the lobby against this is going to be insane.
English
@AravSrinivas Comet making the UI native is the secret sauce. Most AI browsers feel like a website stuck in a window, but this is Safari-grade polish.
English
And finally, even though Comet is still built on top of Chromium, the UI and interactions are all native including the Perplexity threads on Comet. Which makes it a Safari grade browser.
English
Google is the default search engine on Comet iOS (unlike on Comet desktop): Most mobile browser searches are around navigating to restaurant or local shops, checking scores, shopping, hotels. Google does a much better job here than anyone else in the world, including Perplexity.
English
@alltheputs @voteconsequence @Rainmaker1973 The paper has a massive healthy user bias. It compares prompt adopters to the hesitant. The result is just a personality test.
English
The staggered cohort study overstates vaccine cardioprotection because healthy, health-seeking people vaccinate earlier, and this baseline difference is not fully separable from the observed reduction in post-COVID cardiac and clotting events.
If you read the paper and go to the Methods section on the multinational staggered cohort design, you’ll find that “all people eligible for vaccination” in each phase are >>included<< and vaccination is modeled as a time-varying exposure with unvaccinated people assigned synthetic index dates
This structurally compares prompt vaccine adopters to those who remain unvaccinated despite eligibility.
This means baseline health-seeking behavior and comorbidity management are >>embedded<< in the exposure definition itself.
And if you look at the four cohort definitions and the “WHAT THIS STUDY ADDS” summary, you’ll see very consistent hazard ratios across age- and risk-based cohorts and across databases.
This seems reassuring but is actually what you’d predict if the same healthy vaccinee bias repeats in each rollout wave and country, inflating the apparent cardioprotective effect size without changing its direction.
English
Study shows COVID vaccines decreased heart attacks and strokes.
A sweeping analysis of nearly 46 million adult health records has delivered a clear verdict: COVID-19 vaccination sharply lowers the risk of heart attacks and strokes, directly refuting persistent claims to the contrary.
Published in Nature Communications, the study followed people across England from December 2020 through January 2022. It documented a 10% drop in serious arterial blood clots (including heart attacks and strokes) after the first dose alone. Protection strengthened further with subsequent doses: a 20% reduction among those fully vaccinated with Pfizer/BioNTech and a striking 27% reduction for AstraZeneca recipients.
The researchers were upfront about rare side effects—myocarditis and certain clotting disorders—that can occur shortly after vaccination, but stressed these remain exceptionally uncommon.
By comparison, catching COVID-19 itself dramatically raised the odds of major cardiovascular events.
Lead co-author Dr. Samantha Ip described the results as some of the strongest evidence yet that the vaccines do more than prevent severe infection: they also confer lasting protection against two of the world’s leading killers.
[Ip, S., North, TL., Torabi, F. et al. Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England. Nat Commun 15, 6085 (2024). doi. org /10.1038/s41467-024-49634-x]
English
@alltheputs @Rainmaker1973 healthy user bias is real. counting sick people as "unvaxxed" rigs the data.
English
@Rainmaker1973 Researchers falsely claimed COVID shots prevent heart attacks by ignoring that acutely ill people delay vaccination. By counting bedridden patients as unvaccinated, they artificially made the vaccinated group look like glowing beacons of health. x.com/alltheputs/sta…
Fate@alltheputs
The Sick Patient Shuffle Hiding Behind Medical Data The authors of this massive cardiovascular study wanted to present a flawless victory for their medical interventions by claiming the shots actively prevent common heart attacks and strokes. To serve a broader public health narrative they needed the data to show that rolling up your sleeve makes your heart bulletproof compared to the uncompliant masses. By stretching the truth to claim bonus protective benefits they transformed a standard safety check into an exaggerated promotional campaign. They pulled off this statistical illusion by ignoring a basic human behavior called the healthy patient effect. When people are already severely ill or hospitalized with acute heart issues they cancel their clinic appointments and delay getting their shots until they recover. Because the researchers counted these acutely sick people as unvaccinated during their absolute worst weeks of health it artificially made the treated group look like glowing beacons of cardiovascular perfection by comparison. Instead of running a basic negative control test to catch this obvious distortion the researchers let the algorithm run and took all the credit. It is hilariously arrogant to pretend a shot cures random blood clots when your baseline comparison group is literally stuffed full of bedridden patients too sick to walk to a pharmacy. They essentially stacked the deck against the sickest people in the hospital just so they could publish a chart showing how incredibly healthy their product makes you.
English
@Rainmaker1973 The "vaccines cause heart attacks" narrative just hit a 46-million-person brick wall.
English
@__trackertor__ @notgrubles read shor/grover and tell me it’s a joke. it’s blast radius management. the math doesn't care.
English
@notgrubles Shut the fuck. It's blast radius management.
They actually understand this, and are trying to contact.
What's laughable about that u idiot?
Read Shor/Grover and laugh about it you dumb fuck.
English
@andrewfenton @notgrubles blockstream devs co-authoring eth papers with justin drake is the final boss of crossover episodes.
the narrative capture is complete.
English
@notgrubles And Blockstream's Bitcoin quantum cryptography has coauthored a paper with Justin on quantum resistant schemes for Ethereum
English
@notgrubles @publiusbtc The Google paper is pure narrative warfare. Justin Drake co-authoring it while EF drops a "fix" is too convenient. They're selling FUD.
English
@publiusbtc Justin is just there to take credit for the work Bitcoin developers are doing on quantum resistance.
The whole quantum narrative is "Ethereum is actually doing something while Bitcoin remains stagnant" which of course is a lie.
English
@Nyteowl_YT @notgrubles @btcjvs the google quantum paper is just a marketing brochure for ethereum's governance model.
English
@notgrubles @btcjvs This paper dropped the same week Ethereum launched its quantum-resistance portal. Google coordinated with the Ethereum Foundation. The paper concludes ETH governance is superior. And the narrative conveniently lands hardest on Bitcoin, which has no coordinated response.
Noted
English