Jennifer E. Fairman, CMI, FAMI

See you on bluesky bsky.app/profile/fairma…

See you on bluesky bsky.app/profile/fairma…

We love our weird jobs! Great interview with fellow medical illustrator @Vin_the_human Vinald Francis on NPR: marketplace.org/2024/12/06/wha… #weirdjob #medicalIllustrator

The damage from Hurricane Helene is heartbreaking. A good friend’s local shop has been destroyed, leaving workers without jobs. Please consider donating or sharing to help rebuild. Every bit counts. gofund.me/2eeb351d

I just backed Periodical and Annual Cicada Enamel Pins on @Kickstarter kickstarter.com/projects/carol…

So excited to join The Generative AI Growth Mindset's course. Looking for a few friends to join me! maven.com/s/cb4b14cf16

Checkout our new @MolecularOncLab website! anagnostoulab.org We are looking for new wet lab members to join our multi-omics and liquid biopsy efforts (research tech and post-doc level -the latter for folks with a PhD in cancer biology-), contact us if there is interest!

Another great collaboration and the featured cover with @Rock1MD Reyhan Westbrook, Mariann Gabrawy, @JeremyWalstonMD et. al. #kynurenine #NAD #frailty #geriatricmedicine onlinelibrary.wiley.com/doi/10.1111/ac…

#OpenAccess Dual treatment with #kynurenine pathway inhibitors and #NAD+ precursors synergistically extends #life span in Drosophila 🪰🌟🔬 Applause to @ Mariann M. Gabrawy @ Reyhan Westbrook @JeremyWalstonMD @Rock1MD et al. 👏 onlinelibrary.wiley.com/doi/10.1111/ac…

Exciting news of the week - just received my print copies of my latest journal cover! For Diabetes (journal for the ADA) Dax Fu, et. al. @JohnsHopkins @JhuMedart #molecularvisualization #sciart diabetesjournals.org/diabetes/artic…

Jung’s Five Pillars of a Good Life - The Atlantic. I just love this! apple.news/AL_gcMHalTzWqP…

My pick for "the" mobile DNA paper of 2023 is actually two studies published back-to-back @Nature reporting the long-sought structure of L1 ORF2p _and_ fundamental insights into the mechanism by which L1 jumps. Amazing work. 1/n nature.com/articles/s4158… nature.com/articles/s4158…

youtube.com/watch?v=amryk1… Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”. aacrjournals.org/cancerdiscover…

Researchers from @MGHPathology and colleagues discover that structural analysis and inhibition of human LINE-1 ORF2 protein reveals novel adaptations and functions, in a @nature study. doi.org/10.1038/s41586…

@DrMartyTaylor 👏🏻👏🏻👏🏻👏🏻

Excited for the poster session at #SU2CScienceSummit and to share our work on the LINE-1 transposon and its role in cancer diagnostics and mechanisms.

Totally excited to see this! Go, Marty go!

@MGH_RI Link to the paper 👇nature.com/articles/s4158…

Did you know that a significant portion of our genetic code, once dismissed as “junk DNA,” might hold a key to understanding diseases? Scientists have uncovered what could be a game-changer in our understanding of health and disease: massgeneral.org/news/research-…

Using single particle cryo-EM, we determined three structures in different functional states. Apo ORF2p is in an active “thumb up” state; in contrast, apo viral RTs adopt an inactive “thumb down” state. This may explain ‘cis preference’: L1’s penchant for binding its own RNA

We purified ORF2p ‘core’ and determined of a 2.1 angstrom crystal structure, facilitating discovery of two novel domains we name the ‘tower’ and ‘wrist’. These flank the fingers-palm-thumb domains of reverse transcriptase (RT), which grip the nucleic acid like a “right hand”