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Gad

@gadmark

PhD candidate studying transport mechanisms at Rockefeller University

NYC Katılım Mayıs 2011
1.2K Takip Edilen9.2K Takipçiler
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shanshan liu
shanshan liu@shanshanliu1218·
Excited to share our new work! We identified SLC33A1 as the major ER GSSG exporter that maintains redox balance in the ER lumen.
Kivanc Birsoy@KivancBirsoy

Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s4155…

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Kivanc Birsoy
Kivanc Birsoy@KivancBirsoy·
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s4155…
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Rockefeller University
Rockefeller University@RockefellerUniv·
In @NatureCellBio: @KivancBirsoy's lab has discovered that the antioxidant glutathione plays a vital role in maintaining smooth operations of a protein-producing hub in the cell called the endoplasmic reticulum by acting as a protein “proofreader.” 🔗: bit.ly/3Ow8lxM
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Brandon Chen, PhD
Brandon Chen, PhD@BrandonTWChen·
Check out this impressive work and #tweetorial from @gadmark and @shanshanliu1218! If you’re interested in organellar metabolism and metabolite transport, this is a landmark paper on ER redox metabolism and transport👇
Gad@gadmark

Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s4155… 🧵 1/9

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Gad
Gad@gadmark·
@AlonMillet @shanshanliu1218 Thank you Alon! Your proteomics and RNA-seq analysis were a key part of this story. Really appreciate everything you brought to this
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Alon Millet
Alon Millet@AlonMillet·
Was an honor to contribute to this tremendous study co-led by the brilliant duo of @gadmark and @shanshanliu1218. Check out the thread below to learn more about how SLC33A1 works to maintain ER redox balance!
Gad@gadmark

Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s4155… 🧵 1/9

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Gad
Gad@gadmark·
Loss of SLC33A1 shifts PDIs toward oxidized states, triggers ER stress, and creates dependency on ERAD. Disease variants linked to Huppke-Brendel syndrome impair GSSG export. This work connects ER redox biology to neurodegeneration and cancer. 8/9
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Colin McCarthy
Colin McCarthy@US_Stormwatch·
California state reservoir levels are now at 130% of normal, holding 7 trillion gallons of water. Remarkable.
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Keşfet

@nicoledelgaudio @shanshanliu1218 @KivancBirsoy @HiteLabMSKCC @NatureCellBio @AlonMillet @ToshiNakamura51 @RockefellerUniv