Geoffrey McDermott

One more challenge: Even with cheaper library prep, sequencing costs are still massive, especially for 1M+ cell screens So we do a second fun thing! Since VIPerturb-seq is compatible w/fixation, we can phenotypically enrich for ‘Very Important Perturbations’ prior to sequencing

More exceptional technology from the Arc Institute: "ProPer-seq faithfully reproduces gold-standard perturb-seq phenotypes while achieving 4-fold cost reduction and 50% increased gene detection per cell." Seems like a big improvement (in cost and resolution) for one of the most central methods in modern functional genomics. The required inputs to scale "virtual cell" models continue to plummet in cost...