Grimmlab

Hats off to the Oliver Müller lab for their RNA-based directed evolution of novel AAV9 capsid variants for potent species-independent gene transfer to cardiomyocytes of mouse, rat or human origin 👍❤️‍🩹 Thx for the great collaboration & joint publication: liebertpub.com/doi/10.1089/hu… 🤝

Glad that our lab could contribute to 2 AAV papers that have now won the "Paper of the Quarter" award by the German Society of Gene Therapy (@DGGTeV) dg-gt.de/paper-of-the-q… Congrats to Jannik Wagner (Klaus Überla lab) & Burak Demircan / Luca Zinser (Christian Buchholz lab) 🥂🎉

Honored to be a co-author w/ amazing colleagues from Universities Vienna, Stanford, Tübingen & Karolinska Institute on a review on cochlear gene therapy: sciencedirect.com/science/articl… Thx & congrats Lukas, Ellen, Francois, Steffen & Chris 🦻🤗 @CederrothCR @uni_tue @UniHeidelberg #AAV

Congrats to our 2 brilliant students - Anna Schneider & Lea Heckelmann - who graduated w/ a BSc in Biosciences & w/ top grades (1.0) 🥂👏 Fantastic work on new bocaviral vectors for human gene therapy (Anna) or optimized AAV vectors for antibody expression (Lea) 👍 @UniHeidelberg

Happy to see a "Research highlight" article written by our PhD student Jixin Liu published in Signal Transduction and Targeted Therapy: nature.com/articles/s4139… Well done, Jixin, and congratulations 😊👍 !

THX to all PhD students & speakers who made our "HBIGS Summer school 2024" on gene therapy such a success & so much fun 🤗☀️🍨🛳️🎳 ! Thx to @HBIGS_HD for funding & @RevvityLifeSci for extra support! Thx @DominikNiopek & Martina Weiss for the co-organization 🙌🫂 #genetherapy #AAV

Had a fantastic time at the XIX Parvovirus Workshop in Leuven (Belgium). Thx to Els Henckaerts & her local team - you did great 👍👏 Congrats to our PhD student Yumi Sano whose exciting work on new Bocavirus vectors attracted a lot of attention. More here: parvovirusworkshop2024.org

The European Rare Diseases Research Alliance @ERDERA_org kicks off with a bold vision to make Europe a global leader in rare diseases research and innovation. 🚀 Read press release🗞️erdera.org/wp-content/upl…​ 🌍💙 #ERDERA #RareDiseases @EUScienceInnov @HorizonEU @Inserm

Happy, humbled & honored that our lab is a partner in the new & comprehensive "European Rare Diseases Research Alliance - ERDERA" that unites >170 organizations from 37 countries in our joint ambition to deliver tangible solutions to rare diseases patients around the world 🤲🤝🫂

Excited that our collab w/ Wibke Bayer (@BayerWibke) & Matthias Vorgerd on a screen of antibodies against 18 AAV variants is published: frontiersin.org/journals/immun… Congrats to co-authors Ellen Wiedtke, Yumi Sano, Nico Fischer & Lisa Schiller (former) from our lab & all others 🤗 #AAV

Had an absolute blast with the whole lab playing Urban golf in a beautiful sunny area near Heidelberg, followed by après-golf lunch at Neuburg monastery. My heartfelt thanks to each & everyone of you for making this such a fun day & a fantastic team event to remember 🏑☀️🫂🙌🍜🍻

Thrilled that our work with Christian Buchholz (@PEI_Germany) & Petr Chlanda (@ChlandaL) on DARPin-modified AAVs for selective ex/in vivo targeting to CD8+ T-cells is now out in Molecular Therapy: pubmed.ncbi.nlm.nih.gov/39113357/ Congrats to 1st author Burak & all co-authors 🙌🎉 #AAV

Thank you very much to Richard Horgan (@RichHorgan, 2nd from the right) & Ahna Gavrelos (right) from "Cure Rare Disease" (CRD, @CureRareDisease) for their visit to our lab, a great talk by Rich at our institute & a fun dinner in the old city 🥗🍖🥨🍻 Please support CRD 💪 ! #AAV

Happy that our joint article with Ulrike Protzer's lab (@ProtzerLab) on the use of AAV vectors for development of HBV mouse models is now out: pubmed.ncbi.nlm.nih.gov/39044087/ Congrats to 1st author Lisa Schiller, our former MSc student & now PhD student in the Protzer lab 🎊🥂 #AAV #HBV

Congratulations to our postdoc Esra (co-supervised by Kerstin Göpfrich @KGoepfrich ) 👏👍

The 2nd in Communications Biology is from our collab with Klaus Überla's lab (@KUberla) incl 1st author Jannik Wagner & our partners at Sirion/Revvity incl Christian Thirion (@RevvityLifeSci @sirionbiotechmu): nature.com/articles/s4200… Congrats & thank you to all co-authors 🙏👏🥂

Excited about 2 new papers illustrating the potential of our myotropic AAVMYO vector for preclinical evaluation of muscle-directed interventions. The 1st in Nature is from a collab w/ Jeff Chamberlain's lab incl 1st author Hichem Tasfaout (@TasfaoutH): #Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…

Congratulations to our PhD student Felix Bubeck who first-authored this article 🙌 !

Interesting article on the Heidelberg Health & Life Science Alliance (@ResearchLifesci) including on the synthetic AAV / DNA origami vectors that we will develop together with Kerstin Göpfrich (@KGoepfrich) 🙌🧬 #AAV #genetherapy #origami @uniklinik_hd @mpi_mr_hd @UniHeidelberg

Congrats to Marco Thürkauf (1st author), Randall Platt (@randall_platt), Markus Ruegg (@RueggLab) and all co-authors that this paper, which showcases the potential of our AAVMYO vector for in vivo gene knockouts, is now out in Nature Communications: (nature.com/articles/s4146…) #AAV