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How bacteria subvert plant immunity - see the perspective at science.org/doi/10.1126/sc… for this fantastic Science paper by the van der Hoorn lab: science.org/doi/full/10.11…
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Schroeder Research Group
85 posts
Schroeder Research Group
@group_schroeder
Small Molecules etc.
BTI and Department of Chemistry and Chemical Biology, Cornell University Katılım Temmuz 2019
49 Takip Edilen448 Takipçiler
Google: "New math," a term for modern math education, emphasizes conceptual understanding and problem-solving skills over rote memorization. Applied below.
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Congratulations to Dillon and Josh! Their JACS paper reporting new insights into bacterial isoprenoid biosynthesis using a masked DMAPP probe: pubs.acs.org/doi/full/10.10…
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Bile acids as androgen receptor antagonists: amazing work by our Weill collaborators, CJ Guo and David Artis: sciencedirect.com/science/articl…
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Ascaroside-based start-up Ascribe featured at Forbes: forbes.com/sites/daphneew…
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Marian and Safak's metabolic flux paper at Nature: nature.com/articles/s4158… Highlights include establishing the primary use of amino acids and bacterial RNA (!) as a tricarboxylic acid cycle carbon source.
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@elonmusk This means: indirect costs at TESLA are at 100% of direct costs. If 60% is a ripoff, what is it that TESLA is doing?
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@elonmusk I asked Perplexity: "Can you estimate, using publicly available information, the % of overhead cost, in terms of administrative and facilities costs, of the price of a Tesla?" Answer: "SG&A Expenses totaled $5.2 billion, representing 50% of Tesla’s total operating expenses".
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Can you believe that universities with tens of billions in endowments were siphoning off 60% of research award money for “overhead”?
What a ripoff!
NIH@NIH
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above what many major foundations allow and much lower than the 60%+ that some institutions charge the government today. This change will save more than $4B a year effective immediately.
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Our start-up Ascribe Bio ascribebio.com announces investment by ICIG Ventures: agribusinessglobal.com/biopesticides/…
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@Nature It's really a rheostat - if the microbiota produce too much bile acids, which could perturb cholesterol metabolism, the body pushes back by converting the microbiota-derived bile acids into derivatives with the opposite activity.
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Nature research paper: Host metabolism balances microbial regulation of bile acid signalling
nature.com/articles/s4158…
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Congratulations to Tae, Arif, and Chris on publication of their Nature paper, reporting a new class of bile acids that regulate cholesterol metabolism: nature.com/articles/s4158…
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C. elegans as a model for how host-microbe interactions rewire conserved amino acid metabolism: Yong-Uk's paper from Marian Walhout's lab: nature.com/articles/s4225…
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Bingsen's perspective on how metabolic state feeds back on protein function and physiology: "Mechanisms of metabolism-coupled protein modifications" at Nature Chemical Biology: nature.com/articles/s4158…
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Next up: our PODCAST on how host-microbe interactions regulate fat metabolism in C. elegans: soundcloud.com/frank-schroede…… discussing our recent paper in Nature Communications: nature.com/articles/s4146…
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Must listen of the week: The Ascaroside Signaling PODCAST! Everything you always wanted to know about ascaroside signaling, dauer, MOGLs, and modular assembly: soundcloud.com/frank-schroede… More entertaining than "This American Life", but generated with NotebookLM!
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Holoclara announced their Series A! Founded by Andrea Choe, Paul Sternberg, and Frank Schroeder, Holoclara.com is a great success story, nicely summarized here: businesswire.com/news/home/2024…
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Cross-phylum detection of small-molecule signatures: Ping Hsueh's lab reports the identification of a fungal GPCR sensing nematode pheromones (ascarosides), see Nature Mircrobiology: nature.com/articles/s4156…
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Microbiota regulate conserved lipid metabolism via nuclear receptor signaling: see Bennett's paper "Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans" just published at Nature Commun.: nature.com/articles/s4146…
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Protein function is coupled to distinct branches of fatty acid metabolism - see Bingsen's PNAS paper "Amino acid- and protein-specificity of protein fatty acylation in C. elegans" just published at pnas.org/doi/10.1073/pn…
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