Michal Holčapek

Pilot study of screening method for pancreatic cancer using lipidomic profiling of plasma or serum | Communications Medicine nature.com/articles/s4385…

🌟 We are thrilled to announce that another article has just been published in @an_chem Our study, presents a robust and high-throughput workflow for quantifying less polar lipid species in complex biological samples. 🧪✨ doi.org/10.1021/acs.an… #lipidomics #massspectrometry

🚀 New paper out! Our study “Enhancing metabolite coverage using dedicated individual polarity modes in HILIC-MS” is now published in ABC!🙌 link.springer.com/article/10.100…

3/3📘 Published by the International Lipidomics Society in Science Signaling (May 20, 2025). 👉 DOI: 10.1126/scisignal.adw1245 #health #massspectrometry #UPCE

2/3🔬 The recommendations aim to improve reproducibility in LC-MS/MS analysis, a technique that detects 200+ lipid species in one run. Oxylipins also help explain how common drugs like aspirin work. #research #science

1/3🧪 New guidelines for analyzing oxylipins – fatty molecules linked to inflammation, cancer & dementia – were developed by nearly 100 scientists from 70+ institutions worldwide. These lipids are crucial for health and notoriously hard to measure. #lipidomics #UPCE

Novel Charge-Switch Derivatization Method Using 3-(Chlorosulfonyl)benzoic Acid for Sensitive RP-UHPLC/MS/MS Analysis of Acylglycerols, Sterols, and Prenols | Analytical Chemistry pubs.acs.org/doi/10.1021/ac…

Our new article in Analytical Chemistry unveils breakthrough 4D UHPLCxUHPSFC/MS/MS method for comprehensive detection of lipids: pubs.acs.org/doi/10.1021/ac…

Aktivuje prospěšný receptor CAR a blokuje škodlivé účinky PXR. Studie na myších ukázala skvělé výsledky a objev publikoval prestižní časopis Nature Communications. (3/3) nature.com/articles/s4146…

Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards pubmed.ncbi.nlm.nih.gov/39362843/?utm_…

Our cooperation with Petr Pávek group resulted in Nat Commun paper: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model nature.com/articles/s4146…

New article on our software is available online Lipid Quant 2.1: open-source software for identification and quantification of lipids measured by lipid class separation QTOF high-resolution mass spectrometry methods: doi.org/10.1016/j.chem…

Our review article "Recent Advances, Challenges, and Future Directions in the Mass Spectrometry Analysis of Glycosphingolipids in Biological Samples" is now available online: doi.org/10.1016/j.trac…

Our new article "HILIC/MS quantitation of low-abundant phospholipids and sphingolipids in human plasma and serum: Dysregulation in pancreatic cancer" is just published: sciencedirect.com/science/articl…

Our new paper is on complex characterization of GSL is published: doi.org/10.1016/j.jbc.…

The third award of today: the first Jochen Franzen award: Shane Ellis @EllisMSILab @MolHorizons @UOW Congratulations! @BrukerMassSpec @bruker @anzsms @denvms @TheIMSF

Introducing the Lipidomics Minimal Reporting Checklist dlvr.it/SWDjl3 #nature #MassSpecPub

Online now! Introducing the Lipidomics Minimal Reporting Checklist dlvr.it/SWDjDN

We just open the call for postdoc position in lipidomics and mass spectrometry for 18 months. Details on my website: holcapek.upce.cz or Research Gate: researchgate.net/job/965129_Pos…