IISc iGEM

We are glad to announce that we have won a Gold medal at the iGEM Grand Jamboree 2023 held in Paris. This makes it 7 in a row for us!🏅 We would like to thank @iiscbangalore, our mentors and sponsors for their support throughout the project. See you all next year!✌️✌️

We’ll be talking about this detail in our upcoming posts, so stay on the lookout for more! #igem #iisc #stem #synbio #aptamer

Aptamers are cool they have low immunogenicity, less side effects, lower generation time (time taken to create an aptamer from scratch, compared to an antibody), and a smaller half life. The most important - aptamers can be modified for action!

The ‘apt’ in AptalXero comes from aptamer - but what is an aptamer, anyway? Aptamers are sequences of DNA, RNA, XNA, or peptides that have high specificity and binding affinity. Well, even antibodies do that - so why are aptamers special?

There’s still no consensus about the root cause of AD - but we’ve chosen to focus on Alzheimer’s as a tauopathy, and are centering our aptamer-based research on that hypothesis. Stay on the lookout for more cool details about our project! #igem #iisc #stem #synbio #alzheimers

trigger the UPR (unfolded protein response), leading to neuronal damage and apoptosis (programmed cell death).

We’re back with another post on Alzheimer’s Disease, going behind the scenes and exploring two theories for what the root cause may be! One well-established theory talks about amyloid plaques, which are clumps of misfolded proteins called beta amyloid.

AIIM is just around the corner! Make sure you come check out the exciting events planned in the MP20 Hall in the ECE Building, 9:30AM - 6:30PM on 26th-28th July 2024. Scan the QR code to check out the official brochure for the event. Hope to see you there!

We’re happy to announce the eleven iGEM teams participating in AIIM 2024, to be held at the IISc Campus from 26th-28th July! Look out for more details and the event schedule coming soon.

.or ‘zero out’ the symptoms. You may have been wondering why our theme this year is so beachy - well, there’s a reason! The waves represent Alzheimer’s and dementia, with the high tides washing away sand being similar to loss of memory and cognition.

The name 𝐀𝐩𝐭𝐚𝐥𝐗𝐞𝐫𝐨 is a portmanteau of the words aptamer, Alzheimer’s and ‘zero’ - as one of the main focal points of our project is to explore aptamer-based therapeutic and diagnostic strategies for diseases such as Alzheimer’s, with a potential to greatly alleviate,

Presenting… 𝐀𝐩𝐭𝐚𝐥𝐗𝐞𝐫𝐨! Our goal is to develop novel biomedical strategies using aptamer specificity! If that sounds like a lot of jargon, don’t worry, we’ll be explaining it all in our upcoming posts.

iGEM IISc is pleased to announce that we will be hosting the All India iGEM Meet this year, 26th-28th July, on the IISc Bengaluru Campus! Stay tuned for more updates, and we hope to see you there. #igem #aiim #indianigemmeet #igemcommunity #iisc #stem #synbio

Save the date! We’re organising a paper presentation competition in collaboration with Naturalists, the UG Biology Club, on Sunday, 30th December in the Main Lecture Hall (MLH).

NEW LOGO ALERT! THIS IS OUR NEW LOGO FOR THE UPCOMING iGEM CYCLE~ #iGEM #IISc

Through his keen observation and undiminishing scientific temper, Alzheimer laid the foundation for the study of what is today one of the most widespread neurodegenerative diseases. Stay tuned for more updates from iGEM IISc, and our plans for this year!

Alzheimer was the first to observe and record the presence of unusual neurofibrillary tangles and plaques in his patient’s brain tissue. These continue to remain the histopathological hallmarks of AD. In his honor, June is commemorated as “Alzheimer’s and Brain Awareness Month”

Today, June 14th, we celebrate the 160th birth anniversary of the renowned German researcher, clinical psychiatrist and neuropathologist, Alois Alzheimer. #igem #iisc #stem #synbio #alzheimers #psychiatry #neuropathology