Denis

🤑🤑🤑 I love plants vs brainrots😍

A new shot literally regrows knee cartilage. Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA). The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration. In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage. This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes. The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain. Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation. Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery. [Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]

@Indieun Just keep that as the default bro it will look good

Working on a "motion sickness" setting for Catch a Brainrot I don't really get motion sickness from games so I can't tell if this feature works or not, but if you get motion sickness check out the video below and let me know if it makes a difference

@realrusro guilty pleasure

@iscriptfast what about her tho

if you want to make as much money as possible on roblox you need to constantly be listening to michael jackson & michael bolton. no other artists work

@EgirlTwekky exactly

Controversial Opinion Time; Don't get me wrong, the visuals on this game are some of the best I've ever seen on Roblox, and Indieun is extremely talented at what he does, however I feel like more people are just getting massively overhyped from that rather than the gameplay

@GigglingAmoeba9 bots don't spend money

@iscriptfast if i was a bot i'd have way more also tough talk from someone who relies on botted players for their salary

I honestly think the dev behind this game is buying botted accounts to say good things about the game in order to ragebait people and give it publicity

@Call_Me_Tek I'm not a huge fan of the gameplay, and I believe the game will not do well. What I am praising is its super good visuals, the UI is so satisfying I genuinely felt like I was playing a steam game while browsing the UIs

@iscriptfast Seems pretty bad tbh, all the rots have the same skills just randomized from a pool of like 15 ability's and there's no set moves (water beats fire,, etc...) combat just bland and the cam movement is terrible For something so "hype" feels like there was no testing.

Roblox will never be the same this is literally the best game of all time and anyone who says otherwise is not a real human

@Nightmare_2030 @Wishtap_ Yes I've seen them but not a lot of other people did, this game has been seen by way more

@iscriptfast @Wishtap_ He literally does this for every game he makes. He’s being doing this “visual slop” since YouTube simulator or wtv

@3dsrevolver assets that THEY made

@iscriptfast just reusing assets

@Wishtap_ It is way too over the top, but no game has dared this before which is what makes it impressive. We can learn from this to improve our own games without going too over the top. This is genuinely amazing

@iscriptfast Just too many damn camera tweens making me sick lol

@AsharabGFX musicmaxxing

@iscriptfast Based queue

@triffywiffy rap is only good in free time, fries your mind while working

@iscriptfast I personally use the Freddie Gibb method

@Dobigleak @do_bigR @MisfitsGG After months of work? Isn't this just a clone of the drain the lake game that recently blew up

Proud to finally share with yall “Lake Sipping”🥤 After months of work, a massive new project from @do_bigR & @MisfitsGG is finally here. Watch the official trailer now 👀 #ROBLOX #Trailer #RobloxNews #RDC

@MasterGuard4I LOL goat

@iscriptfast oh

@spaghetti341532 when is it?

@iscriptfast you need to constantly be focusing to know when the next tank talk is.

@MasterGuard4I maybe rick astley

@iscriptfast Katy Perry works too twin

@7_Burnt never will

@iscriptfast has this been patched yet