Ivan Mindlin

Taking the momentum of our new-fresh-out-of-the-oven pre-print to fully move to BlueSky. Check the post to check the work: bsky.app/profile/ivanmi… See you there :)

Registration is open until April 25. No abstract is needed, but we encourage to submit (even with preliminary work 😉) More info at ifisc.uib-csic.es/en/events/conf… Registration HERE: forms.gle/eQhWYyC3mjd6Eh… Hope to see you there ☀️

📢 Registration extension📢 Join us in the Embracing Complexity Workshop: Principled and Practical Approaches to Emergence! The workshop is scheduled for June 23-27 2025 at the Institute for Cross-Disciplinary Physics and Complex Systems in Palma de Mallorca, Spain 🇪🇸 👇👇👇

@anton_pashkov03 Hi Anton! No, it’s made by modifying s in eq (5). This is the parameter that we shift :)

@ivan_mindlin Hi Ivan 👋 Great study, congrats 🥳 I have a quick follow-up question after reading the article: was the pharmacological stimulation done by changing the parameter γ in the equation (6) or was it done differently?

📢Paper out📢 “Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness” nature.com/articles/s4200… 👇Brief summary below👇 (1/8)

Many thanks to @jdsitt and @ysanz6 for your supervision🧠, @ETagliazucchi and all the coauthors for the ideas and discussion 💪

In conclusion, our in-silico representation of patients hints that healthy-like brain dynamics might be recovered from DoC models through pharmacological perturbations, especially via serotonergic and opioid receptors, offering mechanistic insights into their effects. (8/8)

Thank you @ysanz6 and @jdsitt for your supervision 🧠and @ETagliazucch and the rest of the co-authors for their contribution 🦾

Interestingly, these shifts did not correlate with the receptor's similarity to structural connectivity but with the overall density of the receptor map. 5HT-2A receptors were more sensitive to perturbations. (7/8)

Many many thanks to the team and to @ysanz6 and @jdsitt for their guidance in this project 😁

🚨First PhD preprint 🚨Here we propose a methodology for pharmacological treatment development of DoC. Our model suggests that high density receptors like 5HT2A and 5HT1A are the optimal to recuperate healthy-like dynamics in a DoC model. biorxiv.org/content/10.110…