@kaulcsmc Do you know the units for the RMST difference vs pbo?
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Jake Astill
1 posts
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4. Revised PEP driven by CV hosp. & NT-proBNP
5. No impact on survival: RMST difference of 6.6, -25.0, 38.2
6. Delayed impact on 6MWD (18m) & KCCQ c/w ATTRACT
7. No significant HTE across subgps
8. No difference in AEs, SAEs favorable for acoramidis
Overall +ive benefit-risk!
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Full results of ATTRibute-CM published
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Key observations
1. Higher survival & lower CV hospitalization c/w ATTRACT (Tafamidis)
2. PEP changed 3 times, once post-12 mo results
3. Win ratio for original PEP: 1.5. 1.1-2.0; revised PEP: 1.8, 1.4-2.22
#article_supplementary_material" target="_blank" rel="nofollow noopener">nejm.org/doi/full/10.10…
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