Jared Covarrubias

Cancer cells are metabolic gluttons that outcompete surrounding immune cells for primary nutrients like glucose. However, the 16-hour fasting regimen exploits a critical survival vulnerability in the tumor. Depriving the system of food for 16 hours forces tumor cells to shift their focus inward toward survival, changing their nutrient consumption. They stop consuming a specific, deprioritized amino acid: isoleucine. This temporary shift creates an isoleucine-rich pocket within the tumor microenvironment. Tumor-infiltrating CD8+ T cells, the body's primary cancer-killing immune cells, grab this available isoleucine. The T cells use the isoleucine to fuel their internal acetyl-coenzyme A (CoA) pool. This triggers a massive epigenetic and phospholipid remodeling program, supercharging their cytotoxic (killing) capacity and driving immune clonal expansion right inside the tumor. What Panda does not tell you because he does not understand: To understand why fasting and deuterium depletion work in perfect synergy, one must look at how cancer cells utilize heavy hydrogen to evade the immune system. The Warburg Effect is a Deuterium Trap: Cancer cells shut down their mitochondria and rely on accelerated glycolysis (the Warburg effect). They do this specifically to route glucose through the pentose phosphate pathway to generate NADPH. NADPH is the subatomic vehicle that carries deuterium into the cell's nucleus. Shielding the DNA: Cancer cells require high concentrations of heavy deuterium to stabilize the structural matrix of their rapidly replicating DNA and to prevent apoptosis (programmed cell death). A highly deuterated cell swells with structured water, forming a dense dielectric shield that lowers its surface voltage. Immune Blindness: Because the tumor cell's surface voltage is warped by deuterium accumulation, passing CD8+ T cells cannot recognize its surface antigens. The tumor becomes a "cold tumor", invisible to the body's immune radar and resistant to standard immunotherapy checkpoint drugs. When an individual undergoes a 16-hour fast, they are not just changing nutrient pathways; they are initiating a subatomic cleansing of heavy hydrogen: Forcing Mitochondrial Resuscitation: Fasting starves the cancer cell of the continuous glucose stream required to fuel its protective, high-deuterium glycolytic pathway. This forces the tumor to attempt oxidative phosphorylation (mitochondrial respiration). The Nanomotor Blowout: Because the cancer cell's internal matrix is highly deuterated, forcing it to run its mitochondria causes heavy deuterium ions to hit its ATP-synthase nanomotors. This shears off the nanomotors, triggering a massive, targeted explosion of Reactive Oxygen Species (ROS). Restoring Immunogenicity: This sudden flood of ROS damages the tumor cell from the inside out, shattering its dielectric shield, raising its surface voltage, and exposing its antigens to the tumor microenvironment. Non coherent UPEs from the ROS de-frag the water lattice of the cancer. Panda will never get to this level of understanding. But I will get you there. Simultaneously, the 16-hour fast releases the isoleucine that fuels the CD8+ T cells' acetyl-CoA pool. The result is a total reversal of the battlefield: the tumor cell's protective shield is dropped, and the T cells are given the exact metabolic fuel they need to initiate the kill.

That's wild the refs missed two obvious holding calls in this Championship game.

Fans can make excuses all they want about Collins, Schultz and Brown being out, but that’s no excuse for Stroud making bad decisions and receivers dropping passes. This didn’t happen during the season.

Horrible throw by Purdy. He has made some bad decisions

Zach Charbonet is running so well tonight. If he keeps it up Sea is gonna win and it won't even be close. The Run game sets up that play action pass for Darnold and SF won't be able to stop it. #SEAvsSF

@HoustonTexans 🐍

It's his birthday today so why not give out a signed Woody Marks jersey. Like and comment "🐍" for a chance to win!

In the last three standalone games, there have now been at least two calls so horrendously bad and inexplicable that the broadcast officiating expert--a person almost always inclined to give the refs the benefit of the doubt--has declared them flat-out incorrect.

Pass the PRIME Act to bypass the meat processing oligopoly that prevents regenerative grass farmers from marketing their beef to local consumers. Good for farmers, good for the environment, good for you.

Google triathalon deaths or cardiac death in winter so you understand why this is critical. In winter UVA and IRA light are not present enough. This stresses the melatonin/dopamine/ATP system. You will see that triathalon deaths occur mostly during the swim or immediately after it. Why? Winter the cooling have a link. It is the same reason you face your seasonal demise but how it happens in you is a bit different. These athletes are all carb adapted because of their beliefs tied to performance. This changes the protein confirmations on most of the proteins used in the mitochondria. The cytochromes being the most important where quantum tunneling occurs. Once electrons are tunneled they head toward oxygen to reduce it. The inner mitochondrial membrane also water micelle's around it (MINOS) they have polarized water around it that contain's protons. The matrix has portons in it that are transfered to the ATPase to make ATP. When they are in a warm environment their proteins have a certain confirmation because they are dehydrated from the task but also because they are living carbs 90% of the time. In the warm environment it is not a problem for them because they are recycling ATP via the fast pathways you learned about in EMF 4. IR-A light also can augment ATP production. Remember what I taught you in the Energy and Epigenetic series. As temperature goes up entropy increases in a system. When entropy increases, water density is less dense. This changes how water can work with sunlight. When water density is less, the water contains less oxygen and less electrons. When oxygen is lowered less ATP is made. When oxygen is lowered it cause methylation defects via TET enzymes. This means that in a warm environment you are running more hypoxic and you perceive a need for carbs to offset this set of circumstances. Could UVA and IRA light help this? Yes, but this is not always possible during the swim when people have most of their body covered up by a suit and sponsors in the colder water. As long as all those condition stay the same the body and system adapts properly. When they hit the water or cold temperature they immediately leave a warmer environment during the run or the bike ride........This radically changes the situation to the living system. Remember what I taught you from the CT series. In water heat transfers occur 24 times more quickly than they do in air. The sensory systems in the PNS are all designed from an evolutionary standpoint to respond to transient environmental changes and not the status quo. This is the essence of sensory receptor adaptation in humans. This is where the shit begins to hit the fan for the athlete or person in cold when they are carb adapted or not going enough solar exposure. The cold receptors sense the transient change and send it to the brain and the mitochondria in coherent water. The water surrounds the mitochondrial membrane. This temperature change changes the molecular arrangements of proteins and fats in the outer and inner mitochondrial membrane. It also changes the molecular structure bonding angles, and the rotations of the bonds in these molecules. This implies there is electronic, molecular, and rotational changes in these proteins to alter its function in a quantized fashion. So the body, specifically the mitochondria, begin rapidly to sense this "change in matter" and the proteins and water around the mitochondria react in quantum fashion to this change. But what can not happen in these people? They need ATP to unfold their new protein confirmation to bind more water inside the cell to meet the new environmental demands. They can not do it for two reasons. They are dehydrated and they do not have the ability to make enough ATP to match the protein and water changes inside the cell to the radical temperature change, so what happens? They make less ATP and transfer less energy via the water micelles and this all accelerates the process of hypoxia. Another big thing happens. In temps below 62 degrees insulin no longer works in a mammalian cell. If you have no insulin you have no way to work the Krebs cycle to bring metabolic intermediates to the mitochondria. Since all they eat is carbs and protein they have no substrate ready to make ATP. So the cold alone, runs them dry of energy substrates to make ATP very quickly because of their mismatched fuel choices. Since they are in cold water they cannot use IRA light to augment this loss either. The cold water hastens this demise in tissue with mitochondrial density. This is why ketosis is linked with cold temps in nature all the times. As it steepens their muscles begin to hurt but eventually it alters their ability to think because they just think this is a temporary thing they experience from the grueling race. Soon their heart/brain become starved for O2 while they continue the swim. The environmental signals are massive because of the way heat is transferred in water so rapidly. When they emerge from the water the environment changes just as drastically back to the warm........from cold. They have an immediate spike in oxygen reduction in the face of a cytosol and mitochondria now adapted to severe hypoxia. This is the ultimate environmental mismatch that their body is not prepared for on such short time scales. It mimics an acute circadian mismatch to light. When this occurs, oxygen becomes toxic as the hydroxyl free radical.......I taught you about this in the Sept webinar of 2013. When this happens it immediately changes the ability to quantum tunnel electrons in the cytochrome proteins because they are loaded with transition metals. This immediate causes the ability to make no ATP. The one bail out would be solar light, but people are covered in triatholons. When ATP is not made in the mitochondria it causes a cell to lose its meta stability (read the Q & A October webinar 2013 thread here to get the full impact) and the cell begins to reach true equilibrium. It is no longer able to be far from equilibroium. When this happens the brain, heart and skeletal muscles all release water and potassium and become rigid. They can no longer contract and the heart stops in diastolic failure. We call this failing in autophagy. This is precisely how one dies of an AI disease or from sleep apnea. The only difference is the time scales.

How are the Texans offensive line this bad still? Three years running with the offensive line holding this team back and it looks like 70% of the issue is just mental mistakes.

@NickScurfield Pretty good summation of being a Texans fan these last 20-some years.

NATURE STAYS UNDEFEATED. When UV light hits your skin, It turns a substance called 7-dehydrocholesterol (7-DHC) into pre-Vitamin D3, which your body uses to make Vitamin D. But if you stay in sun for too long, any extra 7-DHC turns into harmless stuff like lumisterol This is your body’s way of making sure you don’t end up with too much vitamin D No supplement can replicate this.

The Texans CB duo was LOCK DOWN in the 2024 season 🔒

In the Super Bowl last night, Patrick Mahomes was pressured on 38.1% of dropbacks, the 5th highest pressure rate he's faced in his NFL career. Leading to his 2nd worst performance by EPA in his career (-19.3). #Texans' QB CJ Stroud had an AVERAGE pressure rate of 39.4% this season. In the Divisional Round, Stroud battled a 51.4% pressure rate & posted a 287yd 0 turnover performance (+0.7 EPA) down 2 starting receivers against Kansas City. So for anyone that watched what HOF 2x MVP 3x Champion Patrick Mahomes dealt with last night & could not overcome, just know that wasn't even an average game for Year 2 "Sophomore Slump" CJ Stroud. (@NextGenStats) #HtownMade

I've never seen Mahomes play this poorly

You know your shits cooked when they give up plays like this.

You fools criticizing @sriramk as Indian born criticize Musk as South African born or Jensen as Taiwanese born. It is GREAT that talent around the world wants to come here, not to China, & that Sriram can rise to the highest levels. It's called American exceptionalism.

If he can do it, we can do it.

Happiness (if you want it):* 1. Meet basic needs 2. Avoid cheap dopamine 3. Leave the past alone 4. Limit desires to ones achievable at the edge of your capability 5. Find something beyond yourself (mission, children, God) *Most people want something else.

@iamnot_elon A