@quay_dr I’m also curious how your handling of a publicly traded company, @atossainc, is acceptable in 2026!? $ATOS
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Jbods211
581 posts
How is this acceptable in 2026?
A new JAMA Pediatrics study found that among 100,536 US youths ages 13–21 with clear indicators for HIV prevention, only 1,598 ever filled a PrEP prescription.
That is not a gap.
That is a failure.
The disparities are telling: older youth were far more likely to receive PrEP, males far more than females, and uptake was lower in the South and Midwest. States with LGBTQ+ protective laws did better.
Pediatricians identified at-risk youth, but wrote only a sliver of the prescriptions.
Science gave us a powerful prevention tool.
The system failed to deliver it to the young people who need it most.
Public health does not fail only when medicines do not exist. It fails when access, policy, and clinical inertia keep proven medicines out of reach.
@NIHDirector_Jay at @NIH has talked about how the bottleneck is often not discovery, but diffusion.
This is an unfortunate example of just that.
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Breaking news:
Ultra-processed foods during pregnancy produce significant harm to both mother and child.
High blood pressure in moms, low birth weight, early delivery, fetal distress, all were more common in women consuming UPF.
51% of calories were UPF!
Thank you @RobertKennedyJr and @HHSGov for this new focus to help Americans be healthy and
thank you @NIH @NIHDirector_Jay for funding this work.
Here is the paper:
mdpi.com/2072-6643/18/4…
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@quay_dr @NIH Still not focused on your failing publicly traded company, I see. You are a disappointment to millions of patients looking for BC help and thousands of investors who believed you could lead @atossainc. Clearly, letting people down is your “thing” $ATOS
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In April 2025 I gave two US Senators this draft bill that would provide clear attribution for any lab leak involving research funded by @NIH, via a genetic watermarking requirement.
Despite not being introduced as legislation, I will continue to offer my expertise to improve medical research safety and efficacy.
"Attached is a draft of the BIOSEAL Act of 2025. I think it would be an important legislative effort to balance allowing important pathogen research to proceed but with safeguards that allow attribution if the research causes a laboratory-acquired infection that gets into the community or even spreads more widely. It requires that all research funded by the federal government that involves human or animal pathogens be traceable. This traceability is made possible by requiring all researchers to insert a laboratory-specific 'watermark' into the genome of any organism they intend to work on. This watermark is a silent mutation that is in a position of the genome where it does not change the properties of the pathogen, thus not affecting the research in any way. The location of this mutation in the genome is reported to the federal funding agency within 30 days of funding and the beginning of research. From that time forward, any community infection with an organism that is also under study at a nearby laboratory can be quickly identified as a lab leak, or not, by sequencing the organism. If it has the watermark, there is a 99.99% likelihood it came from that lab (it is not 100% because a natural mutation could, 1 out of 30,000 times, be in the same spot in the genome). If it does not have the watermark, the lab is exonerated."
"The second part of the legislation involves requiring that all sequencing experiments be conducted on machines that have a legally acceptable level of 'chain of custody' for any sequencing on a given machine. That would permit, under a court order with probable cause or the civil equivalent, the investigation of what research was going on at a particular laboratory."
zenodo.org/records/151649…
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Returning from a trip to County Armagh, Northern Ireland, and spending time on land that has been in my family, Qua surname, since at least 1643, I am struck by the audacious mindset of these London bureaucrats.
Just shy of 400 years of continuous farming and cattle grazing.
They should be very careful about disrupting these people...
Matt Ridley@mattwridley
Superb and alarming essay about the bureaucratic nationalisation of the land. "The gamekeeper does more for biodiversity in a single bitter January than any glossy RSPB report produced in a warm office in Sandy... The Digital Domesday Book has been opened. The clerks in SW1 have catalogued every acre. Unless rural England finds its voice, in council chambers, at the ballot box, in the sheer stubborn refusal to disappear, the next Framework in five years’ time will simply record what has already been lost... The Anglo-Saxon chronicler would have recognised the pattern. Judgement Day, it seems, has returned in digital form. This time the conquerors don’t wear chainmail, but wear lanyards and speak of resilience. The resentment will linger just as long."
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@quay_dr @elonmusk Cool. Where does @atossainc rank on your to do list? Probably pretty low based on the lack of returns you had provided shareholders $ATOS
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Among engineering feats, this ranks pretty high.
Thomas Edison, meet your match, @elonmusk
Sovey@SoveyX
SpaceX now has over 10,000 Starlink satellites in orbit, which is honestly an absurd engineering achievement. And no, they are not just up there freelancing and hoping for the best. They stay separated because they are placed in organized orbital lanes, constantly tracked, and able to maneuver when needed. Starlink also uses automated collision-avoidance systems, which is how a constellation this large can operate without turning low Earth orbit into a scrapyard. It’s already the closest thing in the world to a true work-anywhere network and they are just getting started.
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A tar found among Neanderthal sites made from birch tree material is effective as a wound treatment, with activity against Staph.
journals.plos.org/plosone/articl…
Manhattan, NY 🇺🇸 English
Bringing private sector discipline to government may seem painful but will greatly improve outcomes if followed consistently.
Private sector projects are a two cycle engine with two outcomes: money is delivered and results are produced. If successful, more money and more results occur. If unsuccessful, money stops and lessons are learned.
Until now, government spending is disconnected from measurable outcomes. The organizing principle of government spending is that if there was a failure, it is because there was too little spending not because there might be fundamental issues with the project.
Aligning @NIH outcomes with the health needs of Americans, who are the 'venture capitalists' of government science, is a refreshing exercise.
Trump's Budget Again Calls for Billions in NIH Cuts medpagetoday.com/publichealthpo…
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Iatrogenic is a word the medical profession HATES to use.
It means, 'I caused a disease in this patient.'
Here we see a list of commonly prescribed drugs that are used to treat disease X but that, inadvertently, cause a very difficult to treat infection, Clostridioides difficile.
500,000 cases and 30,000 deaths per year in the US, largely caused by physicians.
In addition to basic research, one mission of @NIH needs to be physician education...
so that the word iatrogenic disappears from medicine.
Commonly prescribed drugs as risk factors for Clostridioides difficile infections: a Swedish population-based case–control study gut.bmj.com/content/early/…
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@quay_dr Hey Steve. Why don’t you go ahead and buy some shares of $ATOS on the open market instead of asking for ANOTHER reverse approval? You have done nothing for existing shareholders except destroy wealth and opportunity @atossainc
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Leaving Grenoble after a site visit to $ATOS Duchene's muscular dystrophy collaboration laboratory.
I am humbled to work with a husband and wife team with three decades of dedicated work on this devastating disease.
They are hopeful that endoxifen can make a difference.
Apprieu, France 🇫🇷 English
The question "Do you support vaccines?" is usually not a scientific or even medical question.
It is a request for a slogan.
Medicine does not work by slogan.
No one asks whether "I support cancer drugs" or "I support heart disease drugs" in the abstract.
They ask:
which drug,
for which patient,
at what stage of disease,
with what evidence of safety & efficacy,
and with what overall risk-benefit profile.
Vaccines deserve the same scientific seriousness.
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@quay_dr Steven, what are your thoughts on the 10% drop in share price of $ATOS today? Will you ever publicly support your company? @atossainc
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Here is the URL for the Scientific Freedom lecture at NIH. I attended in person, and it was excellent.
videocast.nih.gov/watch/244438a5…
Haarlemmermeer, Nederland 🇳🇱 English
@quay_dr Why are you talking so much on X when @atossainc is in the gutter, losing investors millions of dollars? I would feel so guilty yet you continue to spew nonsense. You are a tone deaf, terrible CEO $ATOS
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You are correct only in the first prior of a Bayesian analysis.
A new virus infecting humans in China has a prior for the cause of about 0.85 spillover, 0.15 lab acquired infection.
But then you start adding additional evidence, location adjacent to a lab, closest natural viruses >1000 km away, genetic features, no seroconversion in Wuhan ruling out abortive practice jumps into humans, lack of posterior diversity, etc. etc.
And the LAI posterior gets to >0.95:
Beyond a reasonable doubt.
Bohdan A. Oryshkevich, MD, MPH@ykramerezha
@quay_dr Dr. Quay, you must provide the human fingerprints, the powder, & the RNA, not DNA. The Wuhan & other Chinese wet markets are de facto labs & have circumstantial evidence. SARS & other viruses have been causing pandemics on their own for millions, if not billions, of years.
Solna, Sverige 🇸🇪 English
@quay_dr Awful year end results for $ATOS! You should be ashamed of your mismanagement of @atossainc When will you drive any shareholder value? Just admit it, you are milking your investors for a salary.
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The case is made from circumstantial evidence.
Examples of such evidence:
Fingerprints on a gun
Powder residue on a hand
DNA under the fingernails of the victim
You don't need to have a wife's body to convict her husband of murder.
The lab origin case is made the same way, with circumstantial evidence.
Use a profanity or its abbreviation again, and I will delete you.
David Young M.D.@davideyoungmd
@quay_dr If you claim you have have access to the lab documents from WIV, and they show COVID sequence, then show them. Workers there have denied that they made COVID. If you can't show the lab notebooks, then you are just speculating. Speculation is cheap. Show the lab books or STFU.
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@quay_dr You ever think about $ATOS price performance? Maybe put some effort into that one. You know, where you are the CEO of a publicly traded company? @atossainc
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Friday’s inaugural Scientific Freedom Lecture at NIH/NIAID got me thinking over the weekend about NIAID’s mission and left me with impressions about what deserves protection, and what deserves reform.
First, NIAID’s bench scientists are a national asset. The quality of the infectious disease and immunology work being done in and around the institute remains extraordinary. America should be proud of that scientific foundation.
Second, great science by itself is not enough. Public trust grows when institutions are transparent, accountable, and visibly committed to the highest scientific and ethical standards.
If NIAID is to strengthen both public confidence and scientific leadership in the years ahead, a few things matter:
• Make transparency the rule, not the exception.
• Protect academic freedom and internal dissent, because science is strongest when debate is welcomed, not suppressed.
• Keep scientific evaluation rigorous, independent, and clearly separate from policy implementation.
• Apply the highest standards of safety, oversight, and transparency to high-risk biological research and international research partnerships.
• Expand the institute’s view of immunology; not only as central to infectious disease, but as deeply relevant to many chronic illnesses affecting millions of Americans, including cancer, heart disease, diabetes, obesity, and Alzheimer’s.
The future of NIAID should rest on two things at once: scientific excellence and public trust.
That is how confidence is rebuilt.
That is how science best serves the public.
And that is how NIAID can do the most good for the most people.
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@quay_dr @HopkinsMedicine Why are you already asking for another Reverse Split approval @atossainc ? Do you really feel like you haven’t already f’d over your $ATOS shareholders enough? You’re an absolute embarrassment of a CEO
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Could an oral bacteria be related to breast cancer initiation or progression?
It sure looks like it based on this excellent paper from @HopkinsMedicine
Modern infectious disease research needs to address the hypothesis that ID may be at the root of many chronic diseases, in this case, breast cancer.
A pro-carcinogenic oral microbe internalized by breast cancer cells promotes mammary tumorigenesis
doi.org/10.1186/s12964…
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The Spike with the FCS and no SNVs is like jack in the box. It is under tension and upon cleavage of the FCS, the freed S1 subunit falls off. The Spike is now blind. So despite the cost of giving up a D614 salt bridge that has been there for 1000 years, it picks G614, breaks a salt bridge, but retains S1. By the time of the later variants, it solved the S1 loss problem another way. So it could return to its happy S614 salt bridge. The alternative variant stabilization is undoubtedly more elegant but I bet it takes at least 2 SNVs, and so was first beaten by the sungle SNV of the crude fix, D614G
Hideki Kakeya, Dr.Eng.@hkakeya
@quay_dr What do you think about the re-emergence of D614 in the Delta and Omicron BA.2 variants? mdpi.com/2036-7481/17/2…
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@quay_dr @DrMakaryFDA Boy oh boy are you, @quay_dr, self centered or what?! Any chance number 8 is coming any time soon with @atossainc? You’ve only been developing Endoxifen for a decade plus at this point. Tick tock, Doc…$ATOS
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Having invented seven FDA approved drugs, I have studied the relationship of the product profile during clinical trials and the real-world evidence profile post-approval.
@DrMakaryFDA is bringing the FDA into the 21st century.
Dr. Marty Makary@DrMakaryFDA
FDA is expanding its use of real world evidence.
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At $ATOS we work tirelessly to develop endoxifen for the universally fatal DMD.
Goal?
Reprogram the muscles to stop making the broken dystrophin protein and return to making the intact utrophin protein that was working fine during fetal development in all of these boys.
futureofpersonalhealth.com/rare-diseases/…
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$29 million to treat 84 kids: The boom in autism therapy is Medicaid’s fastest-growing jackpot wsj.com/health/healthc… via @WSJ
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