Joshua Preston

See our recent work in EJTES developing a calculator to predict stroke risk & risk reduction with antithrombotic therapy for blunt cerebrovascular injury: link.springer.com/article/10.100… Try the calculator: grady-bcvi-calc.shinyapps.io/calculator/ @EmorySurgery @EmoryatGrady #TraumaSurgery #MedTwitter

Excited to share our work on predictors of heart transplant graft dysfunction! Ultra-high-resolution metabolomics shows preop arachidonic acid inflammatory signaling, impaired myocardial energetics are associated with developing severe PGD. @jdpreston30 amjtransplant.org/article/S1600-…

See our recent work in @amjtransplant demonstrating that preoperative plasma metabolomics can identify recipients at risk for primary graft dysfunction after heart transplantation. @JoshuaChanMD @EmorySurgery @EmoryCTSurgery @DrManiCTSurgery @MuathBishawi amjtransplant.org/article/S1600-…

Kudos to @jdpreston30 @JoshuaChanMD & other @EmoryMedicine authors for "Recipient plasma metabolomics as a predictor of heart transplant severe primary graft dysfunction." @EmoryCTSurgery @emoryheartmid @emoryhealthcare @emoryhealthsci pubmed.ncbi.nlm.nih.gov/41407104/

Correct anemia, avoid hyperglycemia and hypothermia, abx 60>15 min pre-op, avoid pressors and epidurals. Reduced colon anast leaks by ARR of 2.5%. Risk Factor–Targeted Perioperative Care Reduces Anastomotic ... : Annals of Surgery journals.lww.com/annalsofsurger…

Here are my predictions for clinical research in the next 5 years: 1. systematic reviews and meta-analyses are replaced with AI evidence synthesis which is 'accurate enough' recognizing that no SRMA applies perfectly to a specific patient. 2. The anti-AI writing tools will finally be put to bed and everyone will use them. The value of research will focus on the data/novelty/impact as opposed to the writing process itself (it's absurd that's what people care about) 3. Large datasets are increasingly valuable to support AI trial emulation --> industry/pharma will pay researchers for the data. 4. Studies will continue to become more phenotyped via large data, biomarkers, imaging (POCUS), physiology as these will be the only studies to reliably produce positive results (outside of cancer and 10K cardio trials) 5. A whole new field of research will blossom ... impact of AI processes on outcomes. The biggest improvements in health outcomes for the next decade will come from these AI adoption studies that will improve diagnosis, management, and also reduce healthcare costs. 6. Someone will start an open sourced journal where the data is published with the study and can be queried by anyone using natural language. Readers can ask direct questions to the data as opposed to relying on the few results published in a given paper. This will open up massive opportunities for post-publication peer review. 7. Someone will come up with a way better way to assess researcher impact than H-index, citations, or even altmetrics. Something that can capture a true impact across multi-channels (academic, public, clinicians, practice, guidelines etc.) 8. Public grant funding will become increasingly scarce... this will drive collaboration between academia and industry which These are just predictions - I think it is a really exciting time for clinical research so am happy to be along for the ride! @john_basmaji @MaratSlessarev @NTFabiano

After rewatching Home Alone, I couldn’t stop wondering: how plausible is the oversleep that leaves Kevin behind? So I wrote a tiny paper and ran the numbers. Merry Christmas! 🎄

Lipidomic analysis in a porcine polytrauma model with hemorrhagic shock reveals a global dysregulation of lipid metabolism. This is most likely due to a disruption of lipoprotein synthesis as a result of ischemic and traumatic hepatopathy. #JoTACS #TraumaSurg #SurgTwitter #SoMe4Surgery #MedTwitter #MedEd #EmergencyMedicine journals.lww.com/jtrauma/fullte…

It’s Stein Time in the Bluegrass. 😼 @CoachWillStein is our new head coach! 📰🔗 bit.ly/48aDAFG

Mark Stoops reset the culture of Kentucky football. He brought toughness, physicality, and grit at a time when the program desperately needed all three. More than that, the high points of his tenure here fostered belief. Streaks ended. Bowls won. Standards risen. Under his leadership, Kentucky became a program that, at our best, could compete with anyone. I’ll remember his era as one defined by competitiveness and genuine excitement. I was in the stands for much of it, and saw with my own eyes the energy around our state and inside Kroger Field on gameday when Kentucky football was right. For a long stretch, Coach Stoops made it right. I am personally grateful to Mark for everything he has dedicated to this program over the last 13 years. Recent seasons have been disappointing. The combination of factors required to win at the highest level of college football has shifted dramatically. For Kentucky football to take the next step, it’s time for the next chapter. Let’s go make it happen.

It is really worth noting how big I think it is that Mark Stoops renegotiated his buyout so it could be paid out in a term of years, rather than upfront It helped UK quite a bit and he didn’t have to do it. I think this makes a future celebration of his time here easier as well

Lots of great times here I love making these types of videos so I can say ‘hey, I was there for that one’ or ‘I remember what I was doing during that game.’ Thank you Mark Stoops. He did a lot of great things for the program, and he should be remembered fondly. But it was time.

See our recent review paper in @JTraumAcuteSurg on hypocaloric feeding in trauma patients! @EmorySurgery @EmoryatGrady

Hypocaloric feeding, which balances protein needs but limits non-protein calories, remains a debated ICU nutrition strategy. This review examines the evidence on its role in critically ill trauma patients—assessing safety, feasibility, knowledge gaps, and future research needs. journals.lww.com/jtrauma/abstra…

@venkmurthy Interesting. Seems odd that mortality is their chosen metric of success though. Looking through the paper, the complications they discuss don’t cover things like episodes of hypotension or pressor doses….. are they hiding the ball? Is mortality really the key outcome to measure?

When I first started in medicine idea of not using arterial line in ICU patient was seen as crazy I remember asking why we couldn't just use cuff for a few hours on particularly busy 30 hour call shift Now we know that cuff BP would've been fine because of an amazing & bold RCT nejm.org/doi/full/10.10…

What is evidence-based diagnosis? AKA Bayesian clinical reasoning Watch my 2 minute pitch for why doctors should care

11 papers retracted from a PhD student. Surprising? Not really. Just check the recent news: 1. The rector of a Spanish university ran a citation-inflation scheme. He was one of Spain’s most-cited academics. Springer Nature retracted 75 papers linked to him in 2024. 2. Another highly-cited chemist in Spain was suspended for 13 years by his university in 2023. In June 2025, at least 11 of his papers were retracted for fraudulent practices. 3. A German anesthesiologist has had 184 retractions. He was once one of the leading international figures in perioperative medicine Just wow. 4. A French mega-cited scientist, a director of IHU Méditerranée Infection, had 6 retractions for ethics violations and 50 articles marked by PLOS. He retired after that. 5. A Japan scientist in anesthesiology had > 170 fabricated papers. His career ended. 6. A Harvard professor had her tenure revoked and was fired in May 2025 after an internal misconduct finding. 7. The STANFORD PRESIDENT resigned after data manipulation was found in several highly cited papers. Two Science papers were retracted. 8. A tenured professor from the University of Minnesota resigned in March 2025 after the retraction of a highly cited Nature paper in June 2024 due to manipulated images. 9. A very high-profile professor from Cornell resigned after two dozen retractions. 📍 What’s going on? Very simple. Make metrics the aim, and science disappears. Many scientists pursue careers instead of science. They focus on awards, number of papers, citations… Their labs turn into production factories - factories of low-quality research and low-quality graduates. ❗️Remember: Your career should be a by-product of science. Not the opposite.

Tyler Childers played tonight at Dinosaur World in Cave City

See our recent work in @AmJSurgery, which presents one of the largest single-center analyses of blunt cerebrovascular injuries ever performed, highlighting key stroke risk factors. @EmorySurgery @EmoryatGrady americanjournalofsurgery.com/article/S0002-…

I’m heartbroken to share the shooting in Lexington at Richmond Road Baptist Church has taken the lives of two people. Other injuries — including a Kentucky State Police trooper from the initial stop — are being treated at a nearby hospital. The shooter has also been killed. 1/3