Jeff Handojo

Family forever #COYG #MyPLMorning 🔴⚪️ @Arsenal @htowngooners @11BelowBrewing @B52Brewing @thistledraft

Never a bad time with the family - an FA cup with a lot of laughs and beers! #COYG #MyPLMorning 🔴⚪️⚪️ @Arsenal @11BelowBrewing @B52Brewing @htowngooners

@grokmen321 @AdamSchefter Can’t win games? 🤔 spent last decade with nothing but losing seasons? 🤔🤔 Are you just making shit up to try and justify your fake rage?

Houston Texans dropping $1B+ on a shiny 83-acre Toro District HQ & entertainment zone opening in 2029. Bold move for a team that’s spent the last decade building nothing but losing seasons and fan frustration. Can’t win games, so they’re building a theme park instead. Peak cope.

The Houston Texans announced they are building a sports and entertainment destination that will include their headquarters and training complex. It's going to be an 83-acre project in Bridgeland, which is Northwest Houston, and called “Toro District”. It is scheduled to open in 2029.

Family, footbal, and beer! #COYG #MyPLMorning @Arsenal

Northside Houston Dawn Patrol reporting for duty against Villa - #COYG #MyPLMorning @11BelowBrewing @B52Brewing

Great heavyweight matchup against Chelsea, but even better company and family - #COYG #myplmorning ⁦⁦⁦@11BelowBrewing⁩ ⁦@Arsenal⁩

Bright and early but always faithful #MyPLMorning @Arsenal @11BelowBrewing @FortressBeer @B52Brewing #COYG

Never a bad time with people you love - #coyg #MyPLMorning @thistledraft @11BelowBrewing @Arsenal

@Lacazest Hate that this shirt is growing on me but using the vibes for the match today!

It worked for the first leg, so I’m wearing another yellow Arsenal shirt for the game (in honour of the 2006 away win). Going with the banana kit this time! 🍌

@LanceZierlein Missing dried brisket

Who did this??? - disc golf - walking boot - NFL Draft - "Me cago en tu leche"

@KingofJUCO Sim 2028

@MLBONFOX AsSHAT?

Who will win the AL West in 2025? 🍿

@NamethatYank @JustBB_Media ( o ) ( o ) I’m dying

This hat collection for Major League baseball this year is certainly interesting...

Ready for match day in Texas #MyPLMorning @Arsenal @11BelowBrewing

@LanceZierlein But why? Supposedly some renovations coming to NRG but that’s just hearsay

Time for Texans to come after a new stadium. Not sure how that will be met by the public.

The look of a man doing his best to stay humble, eh? Inject this into my veins, @ErlingHaaland

@mikegolicjr Girl what

Diet Coke > Coke Zero

@JJWatt You left out @Arsenal

Coffee: Made Schedule: Cleared Food: Ordered Sweats: On Let’s have a damn day. - Burnley v. Watford - SMU v. Penn State - Texans v. Chiefs - Clemson v. Texas - Steelers v. Ravens - Tennessee v. Ohio State

Congratulations @kylemoss2027!! 2024 District 17-6A Co-Offensive Newcomer!!

Scaling Down for Efficiency: Medium-Sized Transformer Models for Protein Sequence Transfer Learning • A surprising finding: medium-sized protein language models like ESM2 650M perform nearly as well as the largest ones (ESM2 15B), even when handling complex biological datasets. • The study demonstrates that larger models are not always better for transfer learning, especially when data is limited, making smaller models both efficient and effective. • Mean embeddings outperformed other compression methods across diverse datasets, offering a practical solution for dimensionality reduction without losing critical features. • Smaller models like ESM2 650M significantly reduce computational costs while maintaining high accuracy, democratizing access to advanced protein analysis tools. • Interestingly, the study shows diminishing returns for extremely large models in limited data scenarios, challenging the trend of scaling up indiscriminately. • The analysis spanned over 40 deep mutational scanning datasets and diverse protein sequences, underscoring the generalizability of these findings. • ESM2 650M proved to strike the best balance between performance and efficiency, especially in datasets below 10,000 samples. • This work paves the way for more accessible, cost-effective protein sequence analysis, promoting wider adoption of ML techniques in structural biology. @ClausWilke 💻Code: github.com/ziul-bio/SWAT 📜Paper: biorxiv.org/content/10.110… #ProteinLanguageModels #TransferLearning #Bioinformatics #MachineLearning #ESM2