Jonas Wilhelm

Our split-HaloTag system enables the study of transient biological events on large scales by converting them into permanent fluorescent marks. In our latest preprint, we present an improved version with significantly enhanced stability and performance! doi.org/10.1101/2024.1…

A big thank you to everyone involved: Lennart Nickel, @hsi_yin, @JulienHiblot and Kai Johnsson. For more background on the split-HaloTag system, check out our original paper here: science.org/doi/10.1126/sc…

Our split-HaloTag system enables the study of transient biological events on large scales by converting them into permanent fluorescent marks. In our latest preprint, we present an improved version with significantly enhanced stability and performance! doi.org/10.1101/2024.1…

🔬Ever wanted to spy on your model system? 🕵️‍♂️ Now you can! With bio-orthogonal chemical labeling, we've unlocked the ability to capture transient cellular events. 🌟 Dive in our study in @ScienceMagazine: science.org/doi/10.1126/sc… A 🧵 1/15

🚨 @ScienceMagazine paper alert 👉 A novel chemical labeling method allows transient events in cells to be recorded for later analysis. Congrats to @magnus_huppertz and Jonas Wilhelm and their collaboration partners @MPIforBI, @DKFZ and @HHMIJanelia! mr.mpg.de/14594969/recor…

Here it is - out now in @J_A_C_S : Fluorogenic exchangeable HaloTag Ligands (xHTLs) 🥳 Reduced bleaching for STED microscopy, application in PAINT and MINFLUX on a common protein tag and a second HaloTag for dual-color imaging increase the versatility of the HaloTag platform.

Do you want to change the color of your biosensor on demand? Still have a large dynamic range? Check our preprint on ChemoX! More about it in the thread! (1/7) Congratulation to the team, in particular the twitterless Lars Hellweg. biorxiv.org/content/10.110…