에이전트로 1인 랩이 된다면 빠른 은퇴가 가능할지도.. 예전엔 박사를 하면서 지도교수에게 독립하기 위해 노력했다면... 이제는 교수가 되어 학생들로부터 독립하기 노력해야하는듯?
독립을 위한 작업들이 하나 둘씩 연습이 되는것 같은데..
클라우드로 작업만 잡아두면 1인 랩이 진짜 가능할지도?
Why do pathogenic variants in the same gene lead to different neurodevelopmental outcomes?
Our Trends in Genetics review discusses how variant effects, genetic background, environment, and developmental noise may all contribute.
cell.com/trends/genetic…authors.elsevier.com/a/1mxFv_3rsxXv…
@mahler83 됩니다. 한 3-4일 하면 복리처럼 적립이 되는데, 그때부터 진짜 신세계입니다 ㅎㅎ 하실때 제 지스트에도 적어놨지만, 절대로 웹훅으로 외부 소스를 가져오면 안됩니다. 그 규칙을 명시해야해요. 모든 답은 주어진 위키에서만... 만약 못찾겠다 싶으면, 정보가 없다고 하라고 하시는게 좋아요.
📣 Preprint 🧵: we profiled post-mortem human BA22 (speech cortex) in autism across 100 donors using single-nucleus multiomics (~500,000 nuclei), integrating RNA + chromatin accessibility. Shout-out to my co-first authors @VarunSuresh007 and @YUHANHAO2: biorxiv.org/content/10.648…
“Monogenic” disorders are not so monogenic after all. In Mowat Wilson Syndrome, we show common enhancer variants at RET can modify Hirschsprung disease risk, offering a genetic explanation for phenotypic variability.
medrxiv.org/content/10.648…
Great collaboration with @tycheleturner
📢 Preprint: we present a whole-mouse-brain in vivo Perturb-seq atlas, 7.7 million cells, 1947 disease-associated perturbations, moving toward direct readout of how human genetics rewires cell states & circuits in vivo. Grateful for the Team! @NVIDIAHealthbiorxiv.org/content/10.648…
Excited to share: enhanced capture in vivo multiome Perturb-seq!
Worried about low gRNA recovery and waste reads on cells that can’t assign a perturbation? We engineered gRNA transcripts to stay in the nucleus, enabling efficient multiomic Perturb-seq!
biorxiv.org/content/10.648…