Jian Yang

The GTEx v10 eQTL data have been integrated into the SMR portal: yanglab.westlake.edu.cn/smr-portal/

GCTA v1.95.1 (bug fix)

Connecting genes, cells, and space. Liyang Song’s gsMap framework precisely maps genetic signals onto tissues and single cells, revealing the cellular origins of complex diseases and their spatial organization. Science, beautifully decoded. 🎉Celebrating Liyang Song as a 2025 Westlake Presidential Award winner! 🧬 #WestlakeUniversity #WhyWestlake #StudyAtWestlake #WestlakePresidentialAward #Westlake2025

Our non-coding RNA eQTL paper is out in AJHG!

🌏 It’s registration day! Whether traveling across provinces or continents, our newest undergraduates have arrived—luggage in hand, dreams in heart, and ready to begin their journey as the Class of 2029.🌟 #WestlakeUniversity #ClassOf2029 #StudyAtWestlake #WhyWestlake #RegistrationDay #Convocation2025

We have a couple of updates to GCTA.

Faculty Positions in AI for Life Sciences at Westlake University nature.com/naturecareers/…

A single-authored research highlight paper from our PhD student Liyang SONG is out now in Nature Review Genetics. @liyang_song

Research Highlight by Lin Tang: nature.com/articles/s4159…

This study shows that lowland individuals living at high altitude exhibit accelerated DNA methylation age. nature.com/articles/s4142…

gsMap paper online. Source code: github.com/JianYang-Lab/g…. Results visualisation website: yanglab.westlake.edu.cn/gsmap.

@ShihchengGuo Will do. Thanks for the suggestion.

@jyang1981 It would be fantastic to update GTEx from V8 to V10, as the new version includes more identified eQTLs, significantly enhancing the power of sQTL- and eQTL-based MR analyses.

The SMR Portal paper is now online. nature.com/articles/s4159…

@ShihchengGuo Hi Shicheng, see below for the results for PNPLA3 and NAFLD that I pulled from the SMR Portal (database module).

@jyang1981 Hi Jian, PNPLA3 and NAFLD form a well-known genetic-phenotype pair, with high PNPLA3 expression driving NAFLD. Benchmarking this in the SMR portal could yield valuable insights—keen to explore what this data reveals! #UKBiobank #AllofUsResearch #GenomicsEngland #NAFLD #PNPLA3

SMR Portal: an online analysis, visualisation, and database platform for mapping complex disease genes. Powered by Westlake FutureGene. Try it out at: yanglab.westlake.edu.cn/software/smr_p…. See a tutorial video at: yanglab.westlake.edu.cn/software/smr_p…

*Ten* 3-year post-doc/assistant prof jobs advertised for our Pioneer Centre for SMARTbiomed - address key questions in common complex diseases through development of new stat/comp tools & software. A new Denmark-Oxford collaboration. Critical mass! smartbiomed.dk/join-the-centr…

From genetic associations to genes: methods, applications, and challenges: Trends in Genetics cell.com/trends/genetic…. A review paper from a team effort led by Ting @TingQi2

An update of GSMR

“The extent to which MR methods are robust to directional pleiotropy can vary depending on the specific method used. This underscores the importance of comparing different MR methods in real data analysis before making definitive inferences about causality.” Well done, Angli!

Naomi Wray (@WrayNaomi) works at the interface of genetics, statistics and psychiatric disorders. With early training in quantitative genetics applied to livestock she brought to the field a perspective on the polygenic nature of common complex disease 🧬 cell.com/neuron/fulltex…