Kalpita Rashmi (she/her)

“Well, yes but that’s small, and that, that’s a simple cyst” okay and here I am in pain, and here you all found something and didn’t mention it until I called it out?! Where are these ppl getting degrees I’m so deadass

Love it! Hard to practice but worth trying.

When you eat is more important than what you eat! One can’t undermine the value of body clocks and feeding fasting regime.

Heartiest congratulations to Gukesh for becoming the youngest player to win the World Chess Championship. He has done India immensely proud. His victory stamps the authority of India as a chess powerhouse. Well done Gukesh! On behalf of every Indian, I wish you sustained glory in the future.

Very interesting thread! Evolution is unbelievable.

The man who heals what doctors can't: Gabor Mate. This famous physician & psychotherapist says the root cause of Cancer, Addiction, and Depression is suppressed emotions. Here are 5 ways they secretly control your life - and how to break free: 🧵

@diannahaze Here is a new interactive resource that lists covid-acquired conditions & their relevant studies by clicking on different organ systems. The site also discusses long covid. Created by @_sam_antics longcovidsux.com

Completely agree. Sleep is the most underrated scientific awareness that’s connected with many health issues! I hope it changes.

Having started my career in basic neuroscience research, I have always understood Alzheimer disease to mean the pathophysiology associated with amyloid plaques and tau tangles. As a clinician, I appreciate that the relationship between Alzheimer disease and cognitive impairment is complex. 1. Clinically diagnosing the cause of cognitive impairment is different than diagnosing that the patient has Alzheimer disease (pathology). Many of my patients with cognitive impairment have multiple diagnoses (e.g., sleep apnea, medication-related cognitive dysfunction, depression, previous cerebral infarction), and sometimes have Alzheimer disease (based on biomarker testing). I do what I can to mitigate the effects of all of these conditions, and when Alzheimer disease is present I do not assume that it is the sole or even the primary cause of cognitive impairment. This is true across multiple potential etiologies: for example, I may diagnose someone with cerebrovascular disease and a prior infarct based on MRI findings, but determine that this condition is asymptomatic and not contributing to their cognitive impairment. 2. Given the simplicity of some biomarker tests and the difficulty of clinical assessment, there is a risk that clinicians may diagnose the etiology of cognitive impairment as Alzheimer disease without doing a full work-up. This is why appropriate use recommendations for biomarkers always mandate that biomarker results must be integrated with a clinical evaluation and not used as a “stand-alone.” 3. Alzheimer disease pathology accumulates silently for ~10-20 years before the onset of cognitive impairment. However, during this pre-clinical phase the accumulation of amyloid pathology is associated with many other biomarker changes that appear pathological (e.g., abnormal CSF synaptic biomarkers, brain atrophy, brain hypometabolism). While the brain is remarkably resilient to damage and individuals may or may not develop symptoms, the brain is sick and the pre-clinical phase is a disease state. 4. Suggesting that a disease only exists when organs are severely damaged and failing (dementia) seems counter to what we have learned in other areas of medicine. For example, patients diagnosed with hypertension or asymptomatic coronary artery disease may change their diet and medications to avoid a heart attack. Individuals with asymptomatic chronic kidney disease may or may not go on to require dialysis, but they can be monitored and sometimes treated. 5. There are valid concerns about the stigma and risks of asymptomatic individuals being labeled as having Alzheimer disease given that they may or may not develop cognitive impairment. The solution is simple—we don’t perform biomarker testing in asymptomatic individuals outside of research studies or clinical trials. Again, this has been mandated by appropriate use recommendations for biomarkers. We can help patients by promoting accurate understanding and appropriate use of biomarkers. #EndAlz

Feeling nervous doesn't mean you're unprepared. It means you care about something beyond your control. Anxiety is a caricature artist. It magnifies flaws and minimizes strengths. Gaining confidence is not about denying what could go wrong. It’s about recognizing what might go right.

A thread with a ton of Ph.D., PostDoc, and other opportunities for life science students (1/n)

A summary below 👇

The homozygous Apolipoprotein E (APOE4) genotype is the major risk factor for the development of early Alzheimer’s disease. We engineered an AAVrh.10 viral vector variant to send unique silencing cargo into mice hippocampus. We saw bad APOE4 reduced by 75% !

Online now: liebertpub.com/doi/10.1089/hu… We show significant suppression of APOE4, a major risk factor for Alzheimer's disease, using an effective strategy combining modified AAV capsid with miRNAs targeting APOE4 in mice brain.

Repeat after me: LAB WEBSITES MATTER! While it may seem like a nice-to-have... in today's world, it's a need-to-have. For you, your trainees, and your prospective team members. I couldn't have written this better myself: nature.com/articles/s4225…

The 5 Things Most Doctors Miss When Treating Depression Feeling anxious or depressed means something. Numbing it with medication isn’t just bad medicine—it’s a long-term disaster for the patient. It’s like pulling the batteries out of a smoke detector. In today’s world of 15-minute med checks, most doctors quickly assume you have a brain disorder. But here are the real issues they often overlook: 1) Dissatisfaction at work 2) Relationship troubles 3) Dietary problems (causing systemic inflammation issues/nutritional deficits) 4) Medical conditions like sleep apnea 5) Substance-induced problems (yes, even things like caffeine and nicotine for some) If people got support to fix 1-5, nearly all would be fine without antidepressants—and they’d be much better off in the long run

I am speechless and shocked how things work, justice has to be done-be it any human living in any part of India. Why everything is politicized beyond humanity? #OdishaPolice #justice

#Alzheimer's is a neurodegenerative disease which leads to disability and dependency among elderly people. On #WorldAlzheimersDay, let’s all pledge to raise awareness and provide all the support, love and care to those who are suffering from it.

Thrilled to share that I will join @OhioState as a tenure-track assistant professor in Dept. of Cell Biology & Physiology in Jan. 2025. We will explore novel mechanisms of centrosome regulation in development and disease. Hiring at all levels! Please help RT.