Keely Oltion

A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes Learn more here! rdcu.be/du2ZX

@RuggeroDavide Thanks so much, Davide!

Cells need to maintain proteostasis. Spectacular work from the Taunton lab identify a new ubiquitin-mediated surveillance pathway that monitors ribosome stalling and A site occupancy in elongation & termination. Congrats Jack and ⁦@keely_oltion⁩! cell.com/cell/fulltext/…

Huge thank you to @JordanCarelli, Tangpo Yang, and @wanghychemistry in the lab, and our wonderful collaborators @stephanieksee and @MartinUCSF from the @KampmannLab.

We combine chemical biology, functional genomics, mass spectrometry, and biochemistry to uncover a new ubiquitin signaling pathway at the ribosome, including two newcomers to the ribosome quality control field, RNF14 and RNF25, and the ribosome collision sensor GCN1.

I'm delighted to present this story from the Taunton lab @UCSF in its final form! authors.elsevier.com/a/1gPf4L7PXiq%…

Thrilled to share this exciting story of SR-A3 -- started from organic chemistry, to chemical biology, biophysics, and cancer biology. (1/3) nature.com/articles/s4155…

This was done with contributions from a fantastic group of people, @JordanCarelli, Tangpo Yang, @wanghychemistry, and @stephanieksee and the @KampmannLab.

Incredibly excited to share my graduate work, and the latest from the Taunton lab @UCSF! We think this will open a new dimension of surveillance pathways for elongating ribosomes. biorxiv.org/content/10.110…