Klinman Lab UCB

Congrats to our undergrad Flora who will be starting her PhD in Chemistry at UCLA! @uclachem

Judith gave a phenomenal G.N. Lewis Memorial Lecture today on the Quantum and Classical Behavior in Enzyme Catalysis-her first in person lecture in 2 years!

New insights into the mechanism of an enzymatic Friedel–Crafts alkylation from Nathaniel, Nate, and Cassidy! This was a wonderful collaboration with Terry and Kate from the Boal lab and Denise Okafor. Congratulations everyone!!! doi.org/10.7554/eLife.… @eLife

My fearless team led by talented graduate student John developed a general method to solve structures of biologically reactive states: “Structure determination of high-energy states in a dynamic protein ensemble”⁦@HHMINEWS⁩ ⁦@Nature⁩ nature.com/articles/s4158…

Enhanced Diffusion and Oligomeric Enzyme Dissociation #JACSVirtualIssue #ChemistryinKorea pubs.acs.org/doi/10.1021/ja…

Building on a library of hydroxylase-halogenase chimeras, Michelle Chang and colleagues @MChangGroup used reaction pathway engineering to switch a hydroxylase to robust halogenation activity. Free to read: rdcu.be/cDIjs. nature.com/articles/s4158…

Check out our latest work on directed evolution. Best Kemp eliminase yet. researchsquare.com/article/rs-115…

De novo metalloprotein design go.nature.com/2ZY6Fno A Review article by Matthew J. Chalkley (@chalkley_talk), Samuel I. Mann (@simann13) & William F. DeGrado from @ucsfpharmacy @UCSF

Proton-Coupled Electron Transfer Guidelines, Fair and Square #Electron #Transfer #ProtonCoupled pubs.acs.org/doi/10.1021/ja…

OK. I'll say it. What are we to conclude from the all male @NobelPrize awards in #STEM these past two weeks? 1st. I'm sure the winners were all deserving. There's nothing to take away from them, and that is not my intention. 1/12

A group of researchers have made the first direct observation of how the atoms within water molecules move when excited, a finding that may lead to a more accurate picture of how energy flows during chemical reactions. fal.cn/3i8tO

Check out Judith’s guest blog post on maintaining remote meetings for a more inclusive and sustainable science. nationalmedals.org/stories/remote…

I repeat- I haven’t been this excited about a discovery since CRISPR. We found something enigmatic that, like CRISPR, is associated with microbial genomes. We have named these unique entities #BORGs

As the Fall semester is approaching, I would like to share our lab tutorials for students new to computational chemistry. liu-group.github.io It covers the essential things useful for a new student's Day 1 at a computational chemistry lab(1/3)

Hey, people thinking about applying for the NSF GRFP! Here are some resources! And yes, first year grad student reading this and thinking "oh but that's not me", this means you! Kindly set the imposter syndrome aside for a second and read this thread! ❤️ (1/10)

Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating 1 Iron Atom to Transform a [3Fe–4S] to a [4Fe–4S] Cluster by Zhang, Su, Dzikovski, @majorsmajer, @recoleman08, @biophyschemist, Fenwick, @crane_bc69, @Cupric4747, Freed, Lin @CornellChem in @J_A_C_S pubs.acs.org/doi/10.1021/ja…

🚨NEW PAPER🚨 It’s very hard to look at a cleft in a protein and predict if that cleft can do chemistry. Can we learn what the special sauce is that makes an enzyme active site catalytic? 1/ rdcu.be/cmIgr @natcomms

Congrats @nminneti! 🎉🎉🤔

Read about this initiative in the Spring 2021 MCB Transcript: mcb.berkeley.edu/news-and-event…

Our new preprint on multitemperature crystallography of SARS-CoV-2 Mpro is out! biorxiv.org/content/10.110… @DrAliEbrahim & @blake_riley took a detailed look at how Mpro reacts to being cooled/heated. We hope this helps ongoing antiviral design efforts (e.g. by @covid_moonshot).