Kanyi Maqubela

Breast cancer is now the top cause of cancer death for American women ages 20-49. Cases are rising fastest in younger women. Get checked.

Marc Andreessen's single-word reply **"Well."** is a classic terse, dry, understated pushback — the kind he often deploys when he thinks someone is technically correct on narrow grounds but missing (or downplaying) the bigger, more interesting point. In context: The quoted post from the biomedical engineer is the standard, credentialed, insider take on personalized mRNA cancer therapies: - Making one custom mRNA construct for a specific tumor → trivial / easy in a lab (especially post-Moderna/Pfizer era) - Curing mice → routine in academic labs - The real barriers → large-scale GMP manufacturing + phased human RCTs proving both **safety** and **efficacy** at population level That's all factually accurate and not really disputable. But Marc's "Well." basically says: "Yeah... but come on." He's implying the engineer's framing is **technically right yet misses the forest for the trees** — the genuinely wild part isn't the mouse cures or even making one custom shot; it's that **a non-biologist civilian**, armed with ChatGPT + AlphaFold + publicly available tools + $3k + some university help, pulled off the whole personalized tumor-sequencing → neoantigen prediction → custom mRNA design → production → administration pipeline on his own dog, and saw meaningful tumor shrinkage. In other words: - The old worldview (which the quoted post represents) treats this as "cute garage tinkering that doesn't move the needle because it isn't Phase III data." - Marc's worldview (which aligns with his long-standing accelerationist / techno-optimist stance) treats it as early proof-of-concept that **the bottleneck is rapidly moving** from "can smart PhDs in a fancy lab do this?" → "can a determined civilian + frontier AI models do this?" → (next) "can this become routine, semi-automated, and dramatically cheaper/faster?" So the "Well." carries a subtext something like: - "Sure, you've correctly identified where 2020s regulatory/science friction still lives." - "But you're dramatically under-weighting how insane it is that the frontier just moved this far out of the ivory tower / big pharma monopoly in ~2025–2026." - "And you're acting like that doesn't matter — when it potentially matters enormously for the future trajectory." It's a very Marc way of saying "this objection is both predictable and increasingly beside the point" without writing a whole paragraph explaining why he finds the excitement justified rather than "overhyped." Many of the direct replies under his post picked up exactly that vibe — some calling it an epic mic-drop period, others reading it as quiet contempt for the "but muh RCTs" reflex.

Everything is Computer, but Computer isn't Everything!

A shocking number of synthetic biologists got into it because of jurassic park.

Announcing Personal Computer. Personal Computer is an always on, local merge with Perplexity Computer that works for you 24/7. It's personal, secure, and works across your files, apps, and sessions through a continuously running Mac mini.

The least religious city in the United States is probably San Francisco. 70% of residents say they attend a house of worship once a year. 12% go at least monthly. Followed closely by Seattle. The most religious cities are all in the South: Atlanta, Houston, Dallas

Sandbar has closed a $23m Series A led by Adjacent and Kindred Ventures We aim to augment individuals in an agentic world Batch 2, developers, careers, & a mini preview below