Guo Lab (Sheffield)

Exciting news out of Professor David Chan’s lab! Their latest paper shares findings that are beautifully consistent with our previous work on FIS1-mediated mitophagy. cell.com/current-biolog…

For fun: 'Mature SUMO' youtube.com/watch?v=GuOERA…

"PINK1 SUMOylation regulates basal mitophagy" biorxiv.org/content/10.110…

To meet, learn and discuss: an exciting meeting for sure 😊 protein-degradation.org/symposium/

meetings.embo.org/event/25-sumoy… EMBO Workshop SUMOylation: From discovery to translation 22 – 25 September 2025 | La Grande Motte, France I am sure this will be a good one😊.

This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.

New Primary Research Publication from This Lab: 'SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia' nature.com/articles/s4141…

@MCB_Sheffield @ScienceShef @sheffielduni This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.

📣 New publication alert!! SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia, by @lab_guo @ScienceShef @sheffielduni nature.com/articles/s4141…

For the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.

@MCB_Sheffield @ScienceShef @sheffielduni In this paper, for the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.

'we propose a novel SUMOylation-dependent pathway where the SENP3-FIS1 axis promotes HIM, with TBC1D17 acting as a fine-tuning regulator.'

Amazing four years of my life in ER lab. Thanks to Elena and all the lab members! 🥰🥰🥰

@BCiani Thank you! 👍

@lab_guo nice one!

Happy to be part of the team 🥰 " ... C.G. first identified MFF as a SUMO substrate. . All authors contributed to editing the manuscript." Another set of evidence highlighting SUMO's regulatory function in mitochondrial fission science.org/doi/10.1126/sc…

SENP3 knockout mice exhibit embryonic lethality at day 8.5, characterised by a neural tube defect and abnormal cardiac asymmetry (left-sided). sciencedirect.com/science/articl…

MiDs - MFF - DRP1 actions in mitochondrial fission nature.com/articles/s4155…

"Overall, base editor screening of PTM sites provides a powerful platform to dissect PTM function within signaling pathways." nature.com/articles/s4159…

Collaboration between the mitochondria and the nuclei in protein making cell.com/molecular-cell…

"#1 out of 140 UK Universities"

The University of Sheffield Reviews by students studentcrowd.com/university-l10…