The Ito Lab

Harnessing the Immune System In Situ: A Novel Approach to Broad-Spectrum Tumor Immunotherapy  keckmedicine.org/physician-blog… I appreciate my colleagues in medical/radiation/surgical oncology, staff at Norris, and patients and family members who have participated in this clinical study.

Great to see my lab members, Steven Luong, Joshua Ni and Dr. Hisashi Kanemaru presenting at #AACRIO26! @uscnorris @KeckMedicineUSC @KeckSchool_USC

We are happy to announce that Flow Cytometry and Immune Monitoring Core @uscnorris installed a cell sorter, Cytek Aurora CS, and will starting an assisted-sorting service from this week. Huge thanks to the support of Norris Foundation. We will have a seminar tomorrow (in-person).

#ICYMI: Impact of #Glucocorticoids on #ImmuneCheckpointInhibitor Efficacy and Circulating Biomarkers in #NonSmallCellLungCancer Patients doi.org/10.1158/2767-9… @lab_ito @md_hsu @nievamd @uscnorris @RoswellPark #NSCLC #OpenAccess

It is great to see that our article was selected in the Editors’ Picks from the August issues of the AACR’s 10 peer-reviewed journals. Thank you very much! @AACR @CRC_AACR

Did you know the 💉 steroids used to ease cancer symptoms might interfere with immunotherapy? A new Keck Medicine study shows that high-dose corticosteroids may block cancer-fighting T-cells — making treatment less effective for some lung cancer patients. Dive into the research: bit.ly/44gFpPs #CancerResearch

Our newest article just came out @CRC_AACR! Congratulations on outstanding medical students, Lauren Polyakov and Angelina Lim for your excellent work showing the impact of steroids on ICI therapy and circulating biomarkers in NSCLC patients.

Very proud of my former trainee, Dr. Kajihara presenting his work at the #AAI2025! In collaboration with ⁦@MarkLong_PhD⁩ and colleagues at Roswell Park, we looked at the evolution of genomic signatures in circulating TIL-TCR clones in a patient treated with ICI therapy.

Congratulations to Angelina Lim and Lexi Meyer on their first poster presentations at #AACR2025 !! So proud of all ⁦@uscnorris⁩ ⁦@KeckMedicineUSC⁩ trainees for their outstanding work and collaborative spirit.

@jitcancer @MarkLong_PhD @dkmlv1 @lab_ito We would like to inform you that your post has been published on OncoDaily.com. Thank you for sharing such valuable content. oncodaily.com/science/237278

New #JITC short report: Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy bit.ly/3POrpo2 @MarkLong_PhD @dkmlv1 @lab_ito

New publication from the Ito lab @uscnorris ! Circulating TIL-TCRs with highly homologous TCR sequences may respond differently to immunotherapy, and show distinct transcriptional signatures that are uniquely distinguished by the expression of GZMK. jitc.bmj.com/content/13/1/e…

I'm pleased to share our new study published in Cancer Research Communications. I appreciate the hard work by Drs. Ishigaki, Yamauchi, Long, Hoki, Yamamoto and Oba.

I’m honored to serve as a director of the Flow Cytometry and Immune Monitoring Core and look forward to working with scientists and clinicians inside and outside of the USC.

I would like to congratulate Manali Begur, MS, a medical student @KECKSchool_USC on receiving an ASH Abstract Achievement Award #ash2023!  @USCStemCell @uscnorris

Ito lab member Lauren Polyakov presented her project evaluating the impact of steroids on anti-PD-1 therapy and T-cell differentiation in NSCLC patients. Lauren is an outstanding 1st year student and Saban Summer Research Fellowship recipient @KECKSchool_USC. #SITC2023 @uscnorris

We are actively #hiring a Technical Director of Flow Cytometry and Immune Monitoring Core at the USC Norris Comprehensive Cancer Center. Please let us know if you are interested! Research Lab Manager usccareers.usc.edu/job/los-angele…

Published in Cancer Research Communications, Dr. Fumito Ito and his team have identified a biomarker that indicates which patients with non-small cell lung cancer will respond well to chemoimmunotherapy. Read more about this discovery here: uscnorriscancer.usc.edu/2023/05/15/usc…

Researchers at @uscnorris identified a biomarker that indicates which patients with non-small cell lung cancer (NSCLC) will respond well to chemoimmunotherapy. The biomarker is expressed on T-cells and can be detected with a simple blood test. #MedTwitter keck.usc.edu/usc-research-i…

Predictive and Prognostic Implications of Circulating CX3CR1+ CD8+ #Tcells in #NonSmallCellLungCancer Patients Treated with #ChemoImmunotherapy, by Abdelfatah et al. bit.ly/3m9bMfa @RoswellPark #openaccess