Lack Lab

🧬 Funded PhD Studentships – Vancouver Prostate Centre (UBC) 🧬 Join our team to investigate transcriptional regulation in prostate cancer. Two fully funded PhD positions available. Interested: please send a CV + short expression of interest. #CancerResearch #PhD #UBC

@CanAztekin Many congratulations Can! Very well deserved.

🥳Thrilled to share that our lab has been awarded an ERC StGrant for our project SigReg: Signal to Regeneration! How can we unlock limb regeneration in adult mammals? It’s time to apply what we learned from 🐸 ➡️ 🐭 bio.mpg.de/480424/news_pu…

Passionate about single-cell method development? 🔬 Join our lab as a Postdoctoral Fellow at @UBC and help uncover androgen receptor enhancer mechanisms in prostate cancer. ubc.wd10.myworkdayjobs.com/en-US/ubcfacul…

Congrats to this year’s recipients of the VCHRI Top Graduating Doctoral Student & Rising Star Awards! 🎉 Learn how these up-and-coming research leaders are contributing to the community: vchri.ca/announcement/2…

I am extremely honored to receive @WellcomeTrust Early Career Award - the first-ever given to @kocuniversity and Türkiye 🇹🇷! Grateful to my mentors @tugbabagcionder and @Tamer_Onder.It was pleasure working w/@berilesin_ and excited for what’s ahead w/@merdemercann! #WellcomeTrust

Huge congratulations to @ozlemyedier for receiving the early career award from @wellcometrust to further explore the mechanisms behind epigenetic regulation of cell cycle. I wish her and @Tbo_Lab members success in this exciting project👏 @kocuniversity @_KUTTAM_

Check out our bioRxiv preprint summarizing our work on AR-V7 condensates, their role in activating a specific gene signature, and enhancing its expression in CRPC models. This work, led by post-doctoral trainee @ShabnamMassah, benefited greatly from co-authors and collaborators.

VPC is thrilled for the launch of the Mohseni Institute of Urologic Sciences! This significant leap forward will foster innovation and enhance translational research for many urologic conditions to positively impact patients. prostatecentre.com/news/introduci… @VCHResearch @VCHhealthcare

Core facilities are truly one of the most undervalued assets in an academic institution. They are often treated as also rans, staffed by non tenured faculty with little leeway, and given an exceedingly short runway to become profitable. In an age of shrinking lab sizes and astronomical maintenance contracts, cores will increasingly become the engines that fuel research. Institutions have to invest in core facilities in order to spur innovation and efficiency, and expect some will be a “loss leader” on revenues, with intangible returns on research productivity. For those on the job market, getting to know the institutional core facilities and directors should be an indispensable part of the recruitment process. Talk one to one with some of the core directors. How institutions approach core facilities is a huge “tell” on institutional research ethos.

@LambAlastair @GSTTnhs @GuysUrology Very exciting news!

Excited to be starting next phase at #GuysHospital @GSTTnhs @GuysUrology this week! Looking forward to getting to know new colleagues and patients and learning lots from them all

@Lallousnada @janefoofoo Many congratulations!

Excited to share our study led by @janefoofoo published in Breast Cancer Research! The paper explores novel inhibitors targeting the estrogen receptor activation function 2 (ER-AF2), a promising strategy for overcoming resistance in breast cancer pubmed.ncbi.nlm.nih.gov/39593108/

@MDershewitz Hi Matthew - great question. Although it's outside the scope of this work, it’s unlikely that AR expression can be easily modulated epigenetically, as most tumors have somatic mutations that increase AR copy number. These hard-wired mutations often drive AR expression in CRPC.

@lack_lab Awesome paper. Really impressed. My question...the prostate cancer ADT drugs can cause normal AR to upregulate. Does your research provide any insight into the epig enetics to how to reverse this overexpression and normalize AR gene expression?

@f_hach, @dogancan, @AdelmanLab and Matt Freedman

@CFCE_DanaFarber Deeply grateful to our amazing collaborators who brought this research to life! From data generation to analysis, everyone’s unique expertise was essential. This work shows what team science can accomplish when we come together with a shared goal to improve cancer understanding!

How does AR activation affect gene expression? Our new paper shows it’s less about creating new loops and more about amplifying contact frequency in existing ones. Explore in @NatureComms (rdcu.be/dYYOL) Tweetorial below: #AR #Epigenetics #prostatecancer