MuTaLig, Multi-target drug design
160 posts
MuTaLig, Multi-target drug design
@lig_ta
Dr. Alfonso T. García-Sosa, Assoc. Prof. @UniTartu https://t.co/qp4ZmMFKWx @[email protected]
Katılım Ekim 2018
236 Takip Edilen305 Takipçiler
MuTaLig, Multi-target drug design retweetledi
Finding new & better ways to create drugs improves effectiveness & safety which ultimately benefits our well-being. What is the multi-target paradigm & how can it help?
@stefanoalcaro shares more on the impact of the COST Action MuTaLig @lig_ta & demystifies the concept ⬇️
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MuTaLig, Multi-target drug design retweetledi
Synthesis of 6’-galactosyllactose, a deviant human milk oligosaccharide, with the aid of Candida antarctica lipase-B
#RealTimeChem #CompChem #OrgChem #Organic #ChemTwitter @RoySocChem @UniTartu @TallinnTech @lig_ta
doi.org/10.1039/D2OB00…
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MuTaLig, Multi-target drug design retweetledi
Discovery & Validation of Lmj_04_BRCT Domain, a Novel Therapeutic Target: Identification of Candidate Drugs for Leishmaniasis pubmed.ncbi.nlm.nih.gov/34638841/
#CompChem #MedChem #NTDs @UniTartu @ISTUN_unav @LatinXChem #RealTimeChem @COSTprogramme @lig_ta 1/
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Multitarget compound design #MTDL, #DNN, Random Forests #RF, Graph-Convolutional Neural Networks #CNN #CompChem #MedChem @deep_chem #featurization @unitartu pubmed.ncbi.nlm.nih.gov/33652992/
Alfonso T. García-Sosa@ATGarciaSosa
Androgen Receptor Binding Category Prediction with Deep Neural Networks and Structure-, Ligand-, and Statistically-Based Features #CompChem #MachineLearning #DNN #Toxicology #RF #CNN #MLR pubmed.ncbi.nlm.nih.gov/33652992/
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Machine learning, artificial intelligence, and data science breaking into drug design and neglected diseases onlinelibrary.wiley.com/doi/full/10.10… #compchem #medchem @WIREs_Reviews @unitartu @ISTUN_unav
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MuTaLig, Multi-target drug design retweetledi
PostDoc, Computational Chemistry and Machine Learning Zealand Pharma A/S, DK jobindex.dk/vis-job/h10123… #compchem
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MuTaLig, Multi-target drug design retweetledi
We have a COFUND Marie Sklodowska-Curie PhD position open for ML applied to catalyst discovery | Cool thing 👉 The PhD starts with 3-months of intensive training in computational modeling, data science and ML. Please RT! @MSCActions @hylleraas mn.uio.no/compsci/englis…
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MuTaLig, Multi-target drug design retweetledi
MuTaLig, Multi-target drug design retweetledi
Just learnt that a chiral separation of the design below resulted in an IC50 (fluorescence) of 0.14uM for the (S)-enantiomer, and no activity for the (R)-. This matches the observed binding in the xstal structure, and demonstrates a "textbook example" of chiral selectivity!
Vladas Oleinikovas, PhD 🇪🇺@OleinikovasV
VLA-UCB-1dbca3b4-15 has been now confirmed in the second independent RapidFire assay at 0.42 uM. And chirally pure enantiomer could be twice as potent! More designs to follow!
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MuTaLig, Multi-target drug design retweetledi
Alzheimer. La molécule découverte dans un laboratoire normand bientôt testée sur l’humain ? #Normandie #Caen ouest-france.fr/normandie/alzh… via @ouestfrance
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MuTaLig, Multi-target drug design retweetledi
MuTaLig, Multi-target drug design retweetledi
@bforsb @wojciechkopec3 @Terrasztain @CompBioPhys @mpi_bpc @DelemotteLab If anybody wants to work on free energy calculations, we'll actually have a fully salaried position (I.e., not a stipend) with good conditiond open soon in Stockholm ;-)
Solna, Sverige 🇸🇪 English
MuTaLig, Multi-target drug design retweetledi
👉 We are looking for a #postdoctoral candidate, who will explore a topological approach to make molecules. Find more info and apply using the link below. The position funded by @snsf_ch starts latest Dec 1, 2020.
Please RT
@UZH_Chemistry #openposition
jobs.uzh.ch/offene-stellen…
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MuTaLig, Multi-target drug design retweetledi
I am looking for postdoctoral positions available immediately. *Do not contact me directly* rather apply through academic jobs online. Here is the link and then I will add a tweet per position @chemuoft @UofTCompSci @UofT 🇨🇦 #postdoc matter.toronto.edu/basic-content-… Please RT 1/6
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