
Ben Hardisty, PhD
24.3K posts

Ben Hardisty, PhD
@mathvsoldage
Data mining & text mining on a scale you can't begin to fathom at Unknown. Lover of ☕️ 🥐🥓🐶 My normal is your never. #useR #Rstats #maths #T1D



















What if AI could invent enzymes that nature hasn’t seen? 👩🔬🧑🔬 Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design 14 rounds of directed evolution and over a year of wet lab work. That's what it took to engineer an enzyme for selective C(sp³)–H insertion, one of the most challenging transformations in organic chemistry. DISCO surpasses this with a single plate. No pre-specified catalytic residues, no template, no theozyme, no inverse folding, just joint diffusion over protein sequence and structure. 📝 Blog: disco-design.github.io 📄 Paper: arxiv.org/abs/2604.05181 💻 Code: github.com/DISCO-design/D…





