Matt Angle

Many ECoG proponents claim their modality is equivalent to intracortical when it comes to brain-computer interface (BCI) performance – but the science says otherwise. Intracortical BCIs record single-neuron conversations, while surface-level ECoGs record the noisy, averaged activity of 50,000+ neurons. Even when using powerful AI signal processing downstream, ECoG devices simply cannot recoup the resolution that intracortical BCIs record in the first place. This difference is apparent in speech restoration applications, where intracortical BCIs have demonstrated sub-1% error rates and real-time decoding from 125,000-word vocabularies. ECoG's best clinical results plateau at a three-year-old's vocabulary with multi-second delays. ECoG certainly has its place in recording large sections of the brain, like in seizure and functional cortical mapping. But for advanced neuroprosthetics that demand high-fidelity data, you need access to rich, high-dimensional neural data – and that's only possible through intracortical BCI. Our latest blog explores the neurophysiology, the physics of signal attenuation, and the clinical evidence that shows why intracortical is the leading modality for complex applications. Read on for more. #BrainComputerInterface #Neurotechnology #NeuralEngineering #BCIresearch paradromics.com/blog/intracort…

Our portco @paradromics is accelerating the future of #Neurotech with the launch of the APEX Partnership Program. By partnering with elite institutions, @paradromics is bridging the gap between #BCIresearch and #ClinicalImpact. Congrats to @Matt_R_Angle and the team! #MedTech

Imagine losing your ability to speak and move. Paradromics just got FDA approval to test a brain implant that lets patients control computers and communicate through text or speech... using only their thoughts! CEO Matt Angle joins us today for a TWiST 500 exclusive. Coming soon to X, YouTube, and your favorite podcast platforms. cc: @Matt_R_Angle, @paradromics, @Alex, @Jason

LLMs are injective and invertible. In our new paper, we show that different prompts always map to different embeddings, and this property can be used to recover input tokens from individual embeddings in latent space. (1/6)

(LinkedIn) Paradromics CEO: "In neurotech, secretive is usually a leading indicator for bullshit." linkedin.com/feed/update/ur… #BCI #NeuroTech

Impressive (200+ bps) decoding speeds by Paradromics reported this month. Plus updates from: - E11 Bio - Morgan Stanley - Neuralink - New England Journal of Medicine - Precision - Figure - China and more. Here's everything you need to know about BCIs this month and my opinions:

Another breakthrough has been showcased at GITEX Global, a technology that could enable paralysed individuals to speak again! Matt Angle, Founder and CEO of Paradromics, the company behind an implant that translates neural activity into speech, explained how it will assist people living with paralysis. #DubaiEyeLiveonDubaiOne #BusinessBreakfastonDubaiOne #DubaiOneTv

Layering AI on a crappy BCI doesn't make it equivalent to a high data rate BCI.

@SergeyStavisky @BrainGateTeam Intracortical recording FTW!

I love watching the BCI Award finalist videos every year, which highlight the remarkable breadth and progress of the field. This year the cherry on top was two @BrainGateTeam submissions taking 1st and 2nd place!

Brain–computer interfaces are no longer science fiction. Matt Angle, Founder and CEO of Paradromics, joins Omar Khateeb to discuss how his company is building the world’s highest data–rate BCI. From his neuroscience roots at Stanford to raising capital in Austin, Matt shares how Paradromics is preparing for first-in-human trials in ALS patients, why data rate is the real bottleneck, how their platform stacks up against Neuralink, and why investors like Saudi Arabia’s NEOM are betting on this future. This episode covers the technology, the business, and the ethics behind connecting brains and machines. Episode Breakdown: 00:00 – What is a Brain-Computer Interface (BCI)? 01:02 – Introducing Paradromics and CEO Matt Angle 02:01 – Matt’s background: neuroscience at Heidelberg & Stanford 03:25 – Early BCI research and limitations of older systems 04:46 – Why Paradromics moved to Austin, Texas 06:28 – How Paradromics technology works: recording at the neuron level 09:50 – Surgical process for BCI implantation 11:08 – Paradromics vs. Neuralink: 10x higher data rates 11:53 – First application: restoring speech for ALS & paralysis patients 13:43 – Potential of BCIs in mental health and mood tracking 15:30 – Psychiatry’s challenge: lack of data vs. future of “brain work” 19:06 – Strategic partnership with Saudi fund NEOM 21:27 – Paradromics’ 3–5 year roadmap: hardware + applications 24:10 – Why BCIs could disrupt pharmaceuticals and drug dosing 26:09 – M&A potential in BCI: role of Medtronic, Abbott, Boston Scientific 29:03 – Why medical devices have staying power vs. drugs 30:12 – Market size: $400B+ opportunity for BCIs 32:16 – Cybersecurity and neural data protection 33:49 – The FDA BCI Collaborative Community 34:42 – Upcoming BCI Society meeting in Banff, Canada 35:11 – Closing thoughts & where to find Paradromics online #Medtech #BCI #Neurotech #Neuralink #Paradromics #AIinHealthcare #StateofMedTech

Matt Angle on Paradromics, Neuralink, and the Race to High-Speed Brain Interfaces.   Watch the full episode here: linktr.ee/stateofmedtech   #Medtech #Neurotech #Paradromics #Neuralink #BrainComputerInterface #HealthcareInnovation

Paradromics just rolled out SONIC, a new benchmark for BCIs. Their Connexus system reached an information transfer rate record of over 200+ bits per second (!) with ultralow latency. To put this into perspective - speech runs at around 39 bps and reading up to 45 bps. 200 bits per second lifts the standard and is a huge leap in BCI development. Congratulations @paradromics @Matt_R_Angle paradromics.com/blog/bci-bench…

Building the World’s Highest Data-Rate Brain Interface. Matt Angle on Paradromics.   Watch the full episode here: linktr.ee/stateofmedtech   #Medtech #Neurotech #Paradromics #Neuralink #BrainComputerInterface #HealthcareInnovation

The Connexus® BCI reached 200+ bits per second on the new SONIC benchmark. But data rates don’t tell the full story. In the animation below, you can see these signals transformed into text as quickly as a skilled reader reads. The difference in performance speaks for itself.

@PeterDiamandis Thanks Peter!

Congrats to Paradromics' BCI World Record, achieving an info transfer rate over 200 bits per second (bps) with negligible delay. This is over 20 times faster than the initial reported performance of other intracortical systems like Neuralink. paradromics.com/blog/bci-bench…

@jeffreyleefunk @VGilja @SergeyStavisky @seeingwithsound @BrainGateTeam @DrDavidBrandman @WillettNeuro @djseo @vikash_gilja @BlackrockNeuro_ Well, I guess the market is in need of a new generational company! :) IMHO - Silicon Valley has been overinvesting in unnecessary SAAS prpducts for the last 10+ years, and I think its a good thing that we see more capital flowing into hardware and deeptech.

@Matt_R_Angle @VGilja @SergeyStavisky @seeingwithsound @BrainGateTeam @DrDavidBrandman @WillettNeuro @djseo @vikash_gilja @BlackrockNeuro_ Old examples! Most recent is Nvidia 32 years ago. Only one started founded in the last 20 years is among the top 100 in terms of market capitalization. Uber. See my book unicorns, hype and bubbles

I'd love to read Dr. Jeffrey Funk's thoughts on this. He knows a thing or two (understatement of the year!) about the AI bubble, and next there may come a BCI bubble? Whatever keeps investors happy... @jeffreyleefunk linkedin.com/in/dr-jeffrey-…

@jeffreyleefunk @VGilja @SergeyStavisky @seeingwithsound @BrainGateTeam @DrDavidBrandman @WillettNeuro @djseo @vikash_gilja @BlackrockNeuro_ The startup ecosystem makes it possible to translate breakthrough science into life-changing products. We can point to example technologies that haven't taken off yet, but we can also point to Intel, NVIDIA, Genentech, Qualcomm

@VGilja @SergeyStavisky @Matt_R_Angle @seeingwithsound @BrainGateTeam @DrDavidBrandman @WillettNeuro @djseo @vikash_gilja @BlackrockNeuro_ And that research is great. The problem is the startup system embellishes and exaggerates those advances with so many technologies including 3D printers, VR, AR, blockchain, delivery drones, eVTOLs, space tourism, and hyperloop in the last 10 years.