The Maus Lab

Tumors don’t just experience stress — they weaponize it to evade immunity. From our Journal Club: Bossowski et al. shows stressed tumor cells secrete LCN2, reprogramming macrophages to keep T cells out. A link between stress responses and immune evasion. nature.com/articles/s4158…

Your epigenome may record the exposures of your life. At our Aging & Cancer Lab seminar, Silvana Maas (Seoane Lab) showed how lifestyle and environmental exposures leave marks on DNA that can be decoded to reconstruct exposures linked to early-onset colorectal cancer.

#JournalClub Immune escape may be less about missing immune cells and more about how tumors reprogram surrounding stroma. Ye et al. implicate senescent CAFs. It raises a larger question: what gives rise to stromal states that constrain immune control? aacrjournals.org/cancerdiscover…

#JournalClub Why does immunotherapy fail in most colorectal cancers? Recent study shows it is not T cells, but TGF-β signaling in myeloid cells that blocks immune control. Turning it off restores T cell response. Are myeloid cells the missing lever? 🔗 nature.com/articles/s4158…

Eric J. Chow et al. find that dexrazoxane given with doxorubicin in childhood cancer is linked to improved long-term cardiac function and lower risk of poor left ventricular function in adult survivors. #JournalClub ascopubs.org/doi/10.1200/JC…

Piotr et al. report that intravenous iron in a mouse cancer model increases tumor iron, promotes tumor growth, and blunts anti-tumor CD8⁺ T cell responses, reducing immunotherapy/chemo efficacy. #JournalClub frontiersin.org/journals/oncol…

A shared DNA methylation drift occurs with aging and tumorgenesis in the colon. Age-related inflammation and reduced Wnt signaling, which dysregulate iron metabolism and impair TET activity, drive this epigenetic drift. #JournalClub nature.com/articles/s4358…

Ferritin buffers intracellular iron and protects cells from iron toxicity. Yi et al. show that deleting the ferritin heavy chain (Fth1) impairs normal HSPC function but restricts AML progression and prolongs survival in mice. #JournalClub nature.com/articles/s4137…

A healthy forty-year-old swallows a pill every morning, not because they are ill, but to shape what might happen decades later. Ten Drugs by Thomas Hager shows how medicines reshape not only health, but how we think, live, and build societies. #labreads amazon.com/Ten-Drugs-Powd…

Meet Jie, our newest PhD student. She brings out-of-the-box mechanistic ideas on how myeloid cell metabolism links aging and cancer—and, unexpectedly, serious karaoke skills. We are lucky to have her on the team. mauslab.org/whoweare

Sherpas evolved a rare EPAS1 variant to thrive in low oxygen on the Tibetan plateau. In our A&C Lab Seminar Series, Carlota Arenillas showed how the same EPAS1 variant is selected in hypoxic tumors—convergent evolution across scales. 🧬 aacrjournals.org/cancerdiscover…

Cancer isn’t supposed to strike in adolescence or young adulthood — yet when it does, patients face threats to fertility, disrupted identity and education, and cancers beyond the scope of most oncologists. Dr. Paula Pérez, showed us how she and Vall d´Hebron are changing this.

Cancer isn’t supposed to strike in adolescence or young adulthood — yet when it does, patients face threats to fertility, identity and education, and cancers beyond the scope of most oncologists. This week Dr. Paula Pérez showed us how she and Vall d’Hebron are working for change

When Ning, Francesca & Marc were selected to speak @SENESCEL 2025, they gave it their all, refining every argument and minute. Their talks put our metabolic bottleneck model of aging on the field’s radar. 👏 What do you think drives tissue aging, the cell or its environment? 🤔

10 days left to apply ...

Ready to start the 2nd International @SENESCEL meeting! 2 days of top ageing science in Barcelona at @the_prbb.

Two years ago, Francesca, Ning, and Marc began their PhDs full of excitement — and a touch of worry. Now they stand at the edge of the Valley of Despair. Over tacos and nachos, we toasted our fallen hypotheses. With no emotions left hidden, we’re ready to cross the desert.

🐁Naked mole rats live up to 16× longer than mice, and a new Science study hints their secret may lie in how they sense DNA damage via the cGAS protein. Will we one day inject naked mole rat cGAS to live longer? To be seen… 👀 #JournalClub 🔗 science.org/doi/10.1126/sc…

A year ago, Adelina applied to our lab through the VIDA call — a stellar Medical Oncologist with no bench experience. As a small lab, we had to say no. The next day she came back with an idea: apply for the ESMO Fellowship (deadline in 3 days!). Yesterday she received her award.