@NERevolution What happened to 'we will pay attention to the cold weather markets' with the new schedule? I bet we'll see lots of RBNYvNE in the middle of a blizzard.
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Michael Bruce
344 posts
Michael Bruce
@mdbruce1
CEO scientist, biotech, food, dad, guitarist, skier, footy fan. Tweets are mine.
Katılım Mayıs 2016
153 Takip Edilen72 Takipçiler
This is a great example of people starting and stopping at 'fairness' without actually running the idea through any real world concepts.
Happens everywhere in the world, unfortunately -
X Freeze@XFreeze
Be me, Dutch investor Netherlands approved 36% unrealized gains tax WTF does that even mean Put $1,000 into stocks Year 1: • Stock goes to $2,000 • Government: "you made $1,000, pay $360 cash tax" • MFW I didn't sell anything • Forced to sell shares to pay • Everyone else forced to sell too • Mass panic selling • Stock crashes to $800 • I have $440 left after paying tax Year 2: • Stock recovers to $1,200 • Government: "you made $400, pay $144" • Forced selling again • Price drops to $900 • I have $756 left Year 3: • Stock at $1,000 • Government: "you made $100, pay $36" • Smart money has fled Netherlands • I have $964 in stock • MFW I paid $540 in taxes • MFW stock is back where it started (0% gain) • MFW I only have $460 left • Lost 54% on a stock that broke even MFW the government made more money off my investment than I did Government: "Thanks for the $540! 😊"
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@JMaraganore It's not self inflicted. It's because of the actions of a few well connected and passionate anti vaxxers.
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The self-inflicted damage to our global leadership in biomedical innovation is horrifying to watch.
We need consistent and stable FDA to continue to lead the world in bringing breakthroughs to patients.
How would we have escaped the COVID pandemic without mRNA vaccines? How will we be prepared for future pandemics?
Let’s wake up here!
Stephen J. Ubl@steveubl
For decades, the U.S. has been the engine of breakthrough medicines — launching two-thirds of new drugs first and sustaining the R&D that benefits patients globally. That leadership didn’t happen by accident. It’s the result of policies that reward investment, support scientific risk-taking and protect our innovation ecosystem. Undermining the vaccine market and weakening IP and reimbursement frameworks puts that engine in jeopardy. washingtonpost.com/opinions/2026/…
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@drjohnm Truncated y axis!! Remind me not to have a heart attack near where you work.
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That slide is even worse than the NEJM KM curves with the truncated y-axis graph inserted on the proper graph.
Now show me the curves without massively truncating the y-axis
Thank goodness Vinay is at FDA
Matthew Herper@matthewherper
Here the Moderna flu data the FDA refused to review. This is the most important slide from the company's study of its experimental flu vaccine-- exactly the data FDA said it wouldn't even review. And below is a thread of relevant slides from that presentation and links to other relevant studies I wanted to bookmark. (I'm a reporter who covers this stuff.)🧵1/14
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Even the Wall Street Journal hates what Prasad is doing to science in America. (hint: he's destroying it to feed his own ego and anger)
statnews.com/2026/02/13/dis…
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This is a great thread on the actual data for the Moderna MRNA vaccine.
That Prasad will not review it is a shocking dereliction of duty and represents a threat to science worldwide.
Matthew Herper@matthewherper
Here the Moderna flu data the FDA refused to review. This is the most important slide from the company's study of its experimental flu vaccine-- exactly the data FDA said it wouldn't even review. And below is a thread of relevant slides from that presentation and links to other relevant studies I wanted to bookmark. (I'm a reporter who covers this stuff.)🧵1/14
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@mdonnino @bradloncar This is all true - and it points to something else that we should be doing, especially in the era of AI and big data (and rare side effects), which is much bigger and better post marketing surveillance.
I'd rather something that works gets out there in the wild.
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Fair enough. I hear your points and do see that seems to be the approach often taken. That said, the example of the COVID vaccine story is a little nuanced as we actually had 3 to begin with and the 3rd (J and J) was taken off the market for the comparative analysis to the other two (not placebo). Specifically, J&J had a pause for risk:benefit analysis in April of 2021. At that time the analysis that was performed was a risk:benefit comparing J&J vaccine to "no vaccine" (ie., the placebo analysis). The result favored J&J as the side effect was very rare and therefore the recommendation was to keep on the market. The data then did not change between April and December 2021 when they did a relook. In the relook, the analysis changed to a comparison of J&J versus mRNA vaccines. The subsequent analysis concluded favorably for J&J for placebo but not when compared to mRNA. The decision to compare J and J to mRNA instead of placebo shifted the risk:benefit leading to removal of J&J from the market with the exception of cases where someone could not receive mRNA (initially) and then ultimately it just came off altogether I think because that was not sustainable. Anyhow, I do agree with your points and now do recognize a bunch are going to market as you describe but I also do think safety analyses generally include risk:benefit that generally would seem to include alternative options. At least in the case of JJ, the comparison to other vaccines resulted in FDA removing from the market.
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I stand by this comment from last fall. Moderna and others need to take their messaging to the general public. There’s not going to much public outrage about yesterday’s flu news because there’s been no meaningful public education on mRNA by our industry.
Brad Loncar@bradloncar
Pfizer and Moderna CEOs should do a few town halls around the country with the public, explain the data behind mRNA and more, why it would be beneath our great country to turn anti-science, and allow regular people to ask them questions. You're welcome for the idea.💡
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@mdonnino @bradloncar after all, we had two covid vaccines, each based on its own placebo controlled trial, and we never had a comparison. This was (correctly) viewed as a good thing.
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@mdonnino @bradloncar Controversial take: choice of comparator should be a risk for the sponsor (Moderna) to take. It should not be an FDA mandated item.
FDA establishes safety and efficacy, with data in the label.
More meds in the same space = more choice, lower prices.
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@ScottHanson They need to change the reception rule to: as long as any part of the body touches in bounds after the ball has touched any part of the body so long as it's ultimately controlled.
cameras too good these days.
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One of the biggest holes in football rule books……
if this is out of bounds - (which it is b/c of the “heel after the toe”) - then how are “toe drag swag” catches *in bounds* — when *those* heels ABSOLUTELY end up out of bounds?
#Conundrum
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@CDCgov Wait isn't the full quote "I respectfully disagree that the absence of data that statistically proves...."
Aren't you actually quoting the opposite of what he says?
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@nycexpatmom You should know that early on they went on ventilators because the met the guidelines for it (spO2). By may it was apparent that the guidances didn’t apply.
Every good (level 1) hospital updated their practices by then.
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Phish at the Sphere was wild. One of the most memorable experiences ever. @phish @SphereVegas
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I hate that we have different rules for the main game vs the last two minutes.
Brady Ross@BradyR36
If you ever find yourself feeling bad about your own intellect, just remember that there are HUNDREDS of THOUSANDS of people who believe that this blatant illegal screen should not have been called because “There was only four seconds left in the game.”
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@ScottyNacho Can you imagine a broadway show with an opener?
Hamilton with The Lion King!!!
I mean, really? Maybe you need more splaining
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@ScottyNacho Good for you.
On the other hand, it's irrelevant. The best dead shows did not have openers.
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@ScottyNacho It's not a rock concert, it's a phish show.
Show = one band.
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It's time to ban prior authorization. This would seem to be a pretty simple law to pass.
nytimes.com/2024/03/14/opi…
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New Release TONIGHT at Midnight ET. Were you at this show? What was your favorite part?
The next release to join the LivePhish Catalog is @Phish 11/30/96 ARCO Arena, Sacramento, CA. Full show drops via the App at Midnight ET. livephi.sh/ph961130.
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@bizarchive I was at this show - terrific playing and great energy.
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