Medscape

In April, the FDA announced National Priority Vouchers, clinical trial authorizations, a Breakthrough Device designation, and other updates on therapeutics, diagnostics, and device-based treatments for psychiatric illness. This roundup highlights some of these actions: mdsc.pe/3P2lA9S

🫀 CV imaging is reshaping risk assessment in primary care. Explore how CAC scoring and carotid ultrasound can refine risk stratification, guide individualized prevention strategies, and support shared decision-making. twitter.com/i/broadcasts/1…

Trinity College Dublin's study questions ketamine's efficacy for depression, finding no added benefit over placebo. Concerns rise over ketamine's rapid adoption, safety, and lack of robust evidence, despite its growing use and market expansion. More on the research: mdsc.pe/4nwzs8N

Rapid antimicrobial susceptibility testing in gram-negative bacteremia did not improve 30-day outcomes compared to standard testing, despite quicker antibiotic adjustments. The study suggests limited clinical benefit, impacting future testing practices. mdsc.pe/3PkbDEQ

A single high dose of psilocybin produced measurable changes in the brains of people who had never previously used psychedelics, while also improving their sense of well-being and cognitive flexibility for at least a month, researchers reported. mdsc.pe/3PEb3ln

This National Arthritis Awareness Month, join expert faculty as they discuss rheumatoid arthritis in new activities in the Transforming Patient Care in Immunologic Conditions Learning Center. ▶️ mdsc.pe/3OZYgcJ

We’re launching a new curriculum on continuous glucose monitoring (CGM). When using CGM to guide treatment, what do you prioritize most?

We’re launching a new learning activity on the growing role of nonsteroidal MRAs across the CKM continuum. What most influences your decision to prescribe a nonsteroidal MRA?

Explore new horizons in uveitic macular edema. Gain practical insights to elevate diagnosis and management, refine clinical decision-making, and improve patient outcomes in real-world care. ▶️ mdsc.pe/3Qu0fWT

🧬 CAR T-cell therapies are reshaping treatment across hematologic malignancies. Explore practical strategies for managing CAR T across treatment continuums and supporting patients throughout their care journey. 💉 twitter.com/i/broadcasts/1…

While colorectal cancer (CRC) has long been considered a disease of aging — with about 90% of cases occurring in people older than 50 years — rates of early-onset CRC (EOCRC), defined as diagnosis before age 50, have been rising worldwide. This trend has puzzled researchers as traditional risk factors do not fully explain it. A new study offers a potential clue, pointing to environment exposures, including a commonly used agricultural pesticide, as potential contributors. Rather than focusing solely on known risk factors, researchers in Spain took a novel “exposome” approach, examining the cumulative environmental and lifestyle exposures individuals experience over their lifetime. Read more on the study: mdsc.pe/4uPdGzC

This educational initiative offers concise, clinically focused modules and practical tools to support earlier recognition of depression, individualized treatment selection, symptom remission, and improved daily functioning and quality of life. ▶️ mdsc.pe/42wrW4p

The study, published in Nature Methods and co-led by Shigenori Inagaki, PhD and Takeshi Imai, PhD, describes SeeDB-Live, the first tissue-clearing technique that works on living mammalian tissue without disrupting cellular function. It’s the third generation of Imai’s clearing platform Imai had been asked whether live tissue clearing was possible roughly a hundred times over those years, and he always said no. When asked whether there was a point during the decade when he stopped thinking about it, his answer was blunt: “I totally gave up.” Why had this problem proven itself to be so intractable? For one, tissue transparency isn’t the actual problem; making tissue transparent is straightforward optics. The problem was doing it without killing anything. The field of tissue clearing has historically given neuroscience exquisitely detailed maps of dead brains. SeeDB-Live doesn’t replace those maps, but it offers something the field has never had: a way to watch the living brain at depths it couldn't reach before, using a protein that evolution put there long before anyone thought to look. Tap the link to learn more about the new discovery. mdsc.pe/4dvQyzb

The historical advice to delay peanut introduction until age 3 may have backfired, contributing to a threefold increase in allergy prevalence. As clinical guidelines evolve, the focus has shifted from avoidance to early introduction for allergy prevention. Watch more from Dr. Christopher Labos by tapping the link. mdsc.pe/4eMJsZo

Most of the population fails to consume adequate fiber. Clinicians can guide patients toward the specific types that offer the greatest clinical benefit. Understanding the nuances between fiber sources allows for more targeted recommendations to improve metabolic health and digestive outcomes. Read the full commentary and guidance: mdsc.pe/4dnD0Wh

Hair & scalp disorders remain some of the most common—and complex—conditions in dermatology. Join leading experts for Hair & Scalp Disorders: The Rx Pad & Beyond, at this virtual CME conference focused on practical, evidence-based strategies you can apply immediately in clinical practice. hairscalpdisorders.com #HairScalpRxPB

From sickle cell crises to kidney injury, changing patient profiles and rising temperatures are creating new clinical blind spots. mdsc.pe/4dosdeK

Recent headlines have alarmingly stated dramatic muscle loss for patients on GLP-1s. Yoni Freedhoff, MD, explains why this is a manufactured controversy. Tap the link to read the full commentary: mdsc.pe/42UswJe

Malaria is now considered more manageable than ever before. According to the World Health Organization (WHO), treatment and prevention efforts have prevented about 2.3 billion infections and 14 million deaths since 2000. New vaccines are a major turning point. For the first time in the history of malaria control, two vaccines are available for widespread use: the RTS,S/AS01 malaria vaccine and the R21/Matrix-M malaria vaccine. However, despite medical advances, funding gaps and persistent structural challenges threaten progress. Both vaccines also require complex vaccination schedules involving multiple primary doses and booster shots, creating major logistical challenges in resource-limited settings. The debate is no longer centered on whether malaria can theoretically be eradicated. The more pressing question is whether the global community is willing to aid in the necessary financial and structural resources to achieve and maintain that goal on a long-term basis. Tap the link in to learn more about the vaccines, new strategies, funding concerns, and more. mdsc.pe/4ewMbpP

Physicians are drawn to hospital medicine for a number of reasons. The care is action-packed and involves a wide breadth of skill sets. The shifts are often followed by a number of days off, and once you leave the hospital, the workday is done. But as hospitalists age in the profession, these long days filled with acute care can be more difficult. Hospital systems are trying different ways of retaining aging hospitalists who have an abundance of knowledge that isn’t easy to replace. Not to mention that onboarding new hospitalists and getting them used to the work takes time and resources. mdsc.pe/3R6CdSl