Medscape

Evidence from randomized trials suggests that calcium supplements may not significantly reduce fracture risk in well-nourished adults. mdsc.pe/4bAVwuK

COVID vaccination during pregnancy protects infants from hospitalization during their first 6 months of life. Published in Pediatrics, the study offers valuable insights for clinicians engaging in discussions with pregnant patients about the benefits of vaccination. mdsc.pe/4lEouxn

Are you following the latest practice parameters for Allergic Rhinitis? Watch as our experts break down first-line recommendations for intermittent symptoms and why second-generation oral antihistamines are often the starting point ➡️ x.com/i/broadcasts/1… #CME

Two new major studies tackle what many researchers believe to be the central unresolved issue in the assessment of psychedelics as treatment for depression: Whether the apparent benefits are inflated by failures of blinding. And the results appear contradictory. A large meta-analysis of studies conducted under equal unblinding conditions showed that psychedelic-assisted therapy (PAT) may be no more effective than traditional antidepressants when patients know what drugs they are actually taking. “The efficacy of psychedelic therapy may have been overestimated by not paying attention to blinding-related issues,” lead investigator Balázs Szigeti, PhD, clinical data scientist, Translational Psychedelic Research Program, University of California San Francisco, told Medscape Medical News. mdsc.pe/4rKpPnB

The liver is a mirror to your patient’s overall metabolic health. In our latest episode of #MASHMasters, learn why MASH is a multi-systemic challenge, from CVD to sleep apnea, and why looking beyond the liver is the key to better outcomes ➡️ x.com/i/broadcasts/1…

Researchers have developed new models that not only look like real brain tissue but also respond like it — mimicking mechanical, thermal, and even electromagnetic properties. Unlike traditional models, these advanced prints can better replicate how real tissue behaves during procedures, potentially improving surgical precision and patient safety. mdsc.pe/4cVhiuk

In a Medscape Q&A, Patricia Ford discusses performing stem cell transplants without donor blood — an approach originally developed for patients who decline transfusions but now gaining broader clinical interest. She highlights advances that make these procedures safer, including careful blood management and supportive care strategies, noting the approach may have benefits beyond patient preference. Full Q&A: mdsc.pe/4lMa2n4

Female reproductive cancers are a major driver of mortality in women aged 35–60, based on a large study spanning 20 countries and more than six decades. Breast and gynecologic cancers accounted for much of the excess mortality compared with men, and eliminating them could increase women’s lifespan by about 0.77 years. mdsc.pe/4bTODol

Use of psychotropic medications, particularly selective serotonin reuptake inhibitors (SSRIs) and anticonvulsants, was associated with bone loss at the spine and hip in men with lower BMI, a new cohort study showed. These associations persisted even after adjusting for factors such as socioeconomic status, lifestyle factors, and medications known to affect bone health. mdsc.pe/4lzeWDy

Colorectal cancer in the United States continues to move in two different directions — decreasing in older adults and rising in younger adults, especially in those aged 20-49 years, according to the latest statistics from the American Cancer Society. The ACS report, published online earlier this month, revealed that CRC incidence rates declined by 2.5% annually in adults age 65 years and older but increased by 3% annually in adults aged 20-49 between 2013 and 2022 — higher than earlier estimates of 1%-2% annual increases. The trends are “concerning” and a “stark reminder that we’re seeing a shifting epidemiology,” said Folasade (Fola) May, MD, PhD, MPhil, director of the gastroenterology quality improvement program at UCLA Health in Los Angeles, who wasn’t involved in the analysis. mdsc.pe/4bAN3X8

Stay current on HCM care! Explore the latest updates on CMI therapy and emerging treatment strategies. Learn how new evidence can guide individualized approaches and optimize patient outcomes. ▶️ mdsc.pe/4txFKI1

📣 Invite your patients living with systemic mastocytosis An in-person Community Exchange with @KuykendallMd—designed for connection, shared experiences, and peer support in a safe, small-group setting. 🍽️ Dinner provided | Spots limited 🔗 mdsc.pe/40A4odX

Emergency doctors warned MPs that unsafe A&E conditions and corridor care are leaving staff exposed to rising violence. mdsc.pe/3NPfIjp

A growing debate is emerging as continuous glucose monitoring (CGM) gains traction. While A1C remains a simple, standardized measure of average glucose over time, CGM offers real-time insights into glucose variability, time in range, and hypoglycemia risk. Experts note that each has strengths and limitations: A1C is widely accessible and well-validated, whereas CGM requires devices, training, and ongoing data management. The takeaway? Many clinicians say it’s not about choosing one over the other — but using both together to get a more complete picture of glycemic control. mdsc.pe/4bXn2BR

A sugar solution placed in the mouth before a needle insertion likely curbs newborns’ pain, according to a new Cochrane review. The finding — combined with a 2023 Cochrane review and others — suggests that the longstanding practice now has enough evidence to be standardized across hospitals and used as a “gold standard” in clinical trials, the researchers said. It also adds to growing research on the effects of nonpharmacologic pain interventions for infants — and hints at lingering gaps in our understanding of how babies process pain. mdsc.pe/4bTt9Ic

Nearly every physician eventually faces a malpractice claim — and the raw emotions that come with it. Here’s how to cope with the shock, fear, and anger: mdsc.pe/4sDMXWl

New guidance on the use of GLP-1-based drugs in people with type 1 diabetes (T1D), due to be published later this year, will address the safety and optimal use of these medications which are currently used off-label in this patient population. Although the use is off-label, it has been increasing in recent years, particularly as an adjunct to insulin in people with T1D who also have obesity and/or cardiovascular disease. mdsc.pe/4rM8vPd

Starting in 1 HOUR ➡️ youtube.com/watch?v=SxYDLq… Is your practice ready to operationalize AID for Type 2 Diabetes? Join our live social event to explore real-world solutions AND earn free CME credit. See you there! #CME #T2DMythBusters

A major meta-analysis led by Jack Wilson, PhD, of the University of Sydney found little reliable evidence that cannabinoids effectively treat most psychiatric conditions or substance use disorders. The review showed no benefit for anorexia nervosa, anxiety, PTSD, or opioid use disorder, and insufficient data for ADHD, depression, OCD, and bipolar disorder. Some improvement was seen for cannabis withdrawal, Tourette syndrome, insomnia, and autism traits, but overall evidence quality was low. mdsc.pe/4sheT1N

US weekly magazine Newsweek and data platform Statista have published their annual ranking of the World’s Best Hospitals — regardless of specialty — for the eighth time. The Mayo Clinic in Rochester, Minnesota, ranked No. 1 for the fifth straight year. There were changes, however, just behind it: Toronto General Hospital and the Cleveland Clinic swapped places at No. 2 and No. 3. Stockholm’s Karolinska University Hospital also improved by one spot to No. 4, making it the highest-ranked hospital in Europe. mdsc.pe/4bwSAOv