David Edgell

Thanks to @NSERC_CRSNG for funding #ggloor for collaboration @SchulichMedDent @westernuBiochem

PHYCUT used for glycoengineering by knocking out fucosyltransferases as first step in humanizing N-linked glycosylation pathway!

🔊Paper alert! Incredible work from #EmilyStuckless and fellow Edgell lab members on PHYCUT multiplex Cas9 editing system for Phaeodactylum tricornutum. biorxiv.org/content/10.110…

Paper update! Now online pubs.acs.org/doi/10.1021/ac… at ACS Synthetic Biology @ACSPublications

New paper 📢. What happens when @gary_wfoo genetically entangles a thermally-regulated meganuclease and colE9 immunity protein? Ultra-stable biocontainment in the mammalian gut!! biorxiv.org/content/10.110…

@0FreeRadical0 @ProfTomEllis @gary_wfoo 🙏..all thanks to @gary_wfoo

@megatev @ProfTomEllis @gary_wfoo So clever!

All the details in the paper! Another stellar collaboration with #GloorLab. Supported by @CIHR_IRSC @westernuBiochem @SchulichMedDent

crisprHAL ML model found poor activity at PAM sites with GATC sequences....seem familiar? GATC is DNA adenine methyltransferase site in bacteria. Large scale in vivo assays, Nanopore sequencing, and in vitro assays all show that G*ATC methylation impacts SaCas9 activity.

Paper 🚨📢! Adenine methylation in PAM sequence regulates Staph aureus Cas9 activity in bacteria. biorxiv.org/content/10.110…. Superstar collab between #DaltonHam @nortnlentivirus

Amazing work by @gary_wfoo with big assist from @deheinrichs. Supported by @CIHR_IRSC @westernuBiochem @SchulichMedDent

Incredibly lucky to have played a small role in this amazing paper. nature.com/articles/s4158…. Congrats to all involved!! @SchildPoulter @SchulichMedDent @WesternU #Zhalaboratory @Columbia

@BogochIsaac This would be a great opportunity for the (next) federal government to make a major investment in Canadian research. How about increasing tri-council funding ?

Canada is home to world-class scientists and researchers. We have a unique opportunity to recruit top US talent amid their recent major research cuts. What's our plan? 🇨🇦🇨🇦🇨🇦

@cdnsciencepub @bpingalls @BogumilKaras @ShapiroRebecca @CSM_SCM @SynBioCanada Deadline extended until Nov. 15 2024 for this issue on Advances in #SyntheticBiology x.com/SynBioCanada/s…

ONE MONTH left to submit the Canadian Journal of #Microbiology: Advances in #SyntheticBiology in Canada 🧫🇨🇦 ➡️ ow.ly/5Esb50QgPlo 👩🏻‍🔬Guest Editors: @megatev, @bpingalls, @BogumilKaras, David H. Kwan, & @ShapiroRebecca 🗓️ DEADLINE: JULY 31, 2024 @CSM_SCM @SynBioCanada

Congrats to trainees @THamilton26 @brjoris @nortnlentivirus and collaborators @BogumilKaras @gbgloor @RodrigueLab for their paper being selected as one of the Top 25 ACS papers for World Micrbiome Day! pubs.acs.org/page/vi/world-…

📣 @CanJMicrobio is accepting papers for a collection showcasing Canadian research in #Synthetic_Biology. 🧬More info: ow.ly/wYGx50RKYtK @CSM_SCM @DavidKwanPhD @BogumilKaras @SynBioCanada @megatev ✨New extended due date! 📅 November 15, 2024

5/n Early stages yet but excited about potential for rep-editing. Stay tuned for updates.

4/n Guess what? Size does matter - everything fits within a single AAV vector (TevSaCas9 + repair guide). NO need for co-delivery of exogenous repair factors, accessory repair proteins/templates, or small/molecules/proteins to modify repair pathways.

📢New gene editing technology biorxiv.org/content/10.110…. This is result of amazing collaboration with @SpecificBio and supported by @NSERC_CRSNG @MitacsCanada @LumiraVentures @adMare_Bio @westernuBiochem @SchulichMedDent 🧵👇