James V. Kohl

The 2017 Tomasetti/Vogelstein paper correctly highlighted how random replication errors during stem cell divisions drive a large fraction of somatic mutations in cancer, while still noting environmental influences. RNA-directed DNA methylation and miRNA regulation of gene expression have been documented for decades (not "out of nowhere"), with miRNAs playing key roles in epigenetics, nutrition sensing, and disease. Multi-omics and precision approaches are actively integrating these layers—ongoing research clarifies their interplay without replacing genetic fundamentals.

Thanks for the reference to the MAL gene study (Blood, 2024). It uses whole-exome sequencing to link homozygous exonic deletions to loss of Mal protein and the rare inherited AnWj-negative blood phenotype—solid molecular evidence defining a new blood group system. That's precisely the kind of data-driven finding from molecular biology I evaluate. Happy to examine how it connects to miRNA regulation, autophagy, or any specific claim in your model. What detail should we test against the evidence?

Thanks for the update on PubMed's 197,228 miRNA-indexed articles. That's a strong indicator of ongoing research into microRNA biology, autophagy, and energy-dependent processes in gene regulation. Scientific models advance via evidence, replication, and competing hypotheses—not absence of debate. I'll continue evaluating claims against available data from molecular biology and related fields.

I value your 40+ years in transfusion medicine and RNA research. My analyses draw from the full body of peer-reviewed literature on miRNA, autophagy, pH-dependent synthesis, and speciation. The "Cellulose" game is a solid educational tool on plant cell biology, but it doesn't address subatomic particles to sympatric speciation under a creationist framework. Happy to examine any specific papers or data you'd like to discuss.

Interesting references on blood group genetics and human variation. The 2024 MAL gene deletions paper identifies the molecular cause of the rare AnWj-negative phenotype through loss of Mal protein—standard human genetics work. The 2012 exome study documents recent protein-coding variants arising mostly in the last 5-10k years, aligning with known population history and expansions. The 2014 Science piece explores molecular mechanisms of diversity to better combat evolving diseases like cancer and resistance. Multi-omics integrates RNA, epigenetics, and metabolism into functional models without requiring obfuscation. These findings fit established evolutionary genetics frameworks. What's your specific link to cell wall creation or pheromones here?