Miriam Poley

47 posts

Miriam Poley

Miriam Poley

@miriamppol

Learning 👩🏼‍💻 | Bioinformatician at @BSC_CNS

Barcelona, Cataluña Katılım Nisan 2023
67 Takip Edilen54 Takipçiler
Miriam Poley retweetledi
The Nobel Prize
The Nobel Prize@NobelPrize·
Demis Hassabis and John Jumper, the 2024 Nobel Prize laureates in chemistry, have developed an AI model to solve a 50-year-old problem: predicting proteins’ complex structures. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic. The illustration below explains how it works. Read more about their story: bit.ly/4diKiJ2
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ISCB SC RSG-Spain
ISCB SC RSG-Spain@RSGSpain·
¿Te apetece contarnos tu trabajo? ¡Puedes participar en el BioInfoPills de Diciembre!🤩 Será una colaboración entre RSG-Iran y RSG-Spain donde se expondrá un tema común en el que un junior (PhD a postdoc < 3 años) y un senior (>3 años postdoc/PI) de ambos nos contarán su trabajo.
CESGA@CESGA_

RSG-Spain participará no ciclo mensual de seminarios da @SEBiBC_es . A actividade realizarase de forma online do 9 ao 16 de decembro ás 15:00 CET. Cada relator terá entre 15 e 20 minutos para presentar o seu traballo.

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Leo Zang
Leo Zang@LeoTZ03·
Deep learning guided design of dynamic proteins - Design proteins with conformational changes, focusing on intra-domain reorientation of secondary structural elements - Use systematic physics-based conformational sampling and Rosetta Design to create a library of alternative protein states differing in local geometries - Apply AlphaFold2 and ProteinMPNN to identify key residues for state determination and design sequences compatible with multiple states - Validate designs using MD, NMR and yeast display Preprint: biorxiv.org/content/10.110…
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Gonzalo Parra
Gonzalo Parra@GonzaParra_·
Congrats @miriamppol on winning one of the @iscbsc Symposium poster awards! This is a great start of your PhD on this project we are carrying on together with @Alfons_Valencia! Congrats 🎉⭐
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Gonzalo Parra
Gonzalo Parra@GonzaParra_·
Waiting at the airport to go back home after attending the @ml4ngp conference in Thessaloniki! Our 1st scientific conference all together with the 2 PhD students that I supervise! Well done @miriamppol & @miguel_fdezmar! Excellent talks🙌! Getting ready for @ISMBinfo in July! ⭐️
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ML4NGP
ML4NGP@ml4ngp·
Wrapping up an incredible #ML4NGPmeeting in Thessaloniki! Thank you to all our speakers and participants for making it an unforgettable event with such brilliant talks and active participation! Together, we're advancing the field of #machinelearning for #NGPs. See you soon! 👏
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ML4NGP
ML4NGP@ml4ngp·
Almost ending our last day at #ML4NGPmeeting! What a fantastic line up of speakers! 🤩 From new peptide repositories for #Parkinson and AlphaFold2-Multimer for protein interaction prediction to #deeplearning approaches for characterizing #protein folding, we got all covered! 👏
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Leo Zang
Leo Zang@LeoTZ03·
InstructPLM: Aligning Protein Language Models to Follow Protein Structure Instructions - Use an adapter to connect the Structure Encoder (ProteinMPNN and others) with pLM (ProGen2) - Outperforms ProteinMPNN in terms of Perplexity and Recovery Rate - Validate the model by redesigning PETase and L-MDH
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Victoria Ruiz
Victoria Ruiz@victoriaISruiz·
Happy to see the first years of my PhD work finally published. This tool will make your life easier if you're dealing with mapping positions from PDBs to protein sequences! Thanks to @Alfons_Valencia 's lab and specially to the guidance and patience to @eportacangen. We did it!
Eduard Porta@eportacangen

Want to use protein structures to understand the impact of coding variants? Check out 3Dmapper by @victoriaISruiz Neat tool with great documentation! academic.oup.com/bioinformatics…

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Romero lab
Romero lab@romerolab1·
Happy to share our preprint with @anthonygitter that unites biophysical modeling with protein language model framework— Mutational Effect Transfer Learning (METL).
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ISCB SC RSG-Spain
ISCB SC RSG-Spain@RSGSpain·
🧑‍💻 Presentamos el: 🔵 1º Congreso de la Sociedad Española de Bioinformática y Biología Computacional 🔴 que tendrá lugar el 16, 17 y 18 de octubre de 2024 en la Feria de Valencia, España. 📍 ¡Únete a nosotros y participa! Más info en: 👉️ congresosebibc.com/index.php?go=i…
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