Martin Picard

Best guess is that the series of proteins (enzymes, transporters, etc) act as the "wire." Great question about the correspondences. There likely isn't a direct correspondence for each component. It's a useful heuristic, but living systems are pretty different. Can you think of the parallels?

@MitoPsychoBio 전기 회로에서 에너지가 전자 이동이 아니라 전선 주변 전자기장(포인팅 벡터)으로 빛의 속도로 전달된다는데, 생물 회로에서 산소는 양극, 음식물은 음극일 때, 전선, 전하, 전기장, 포인팅 벡터, 장 기반 에너지 전달은 각각 어디에 대응하나요? 생물에선 단백질이 전선인가요?

Good illustration of the energy resistance principle. When electrons flow with high resistance, the organism responds by slowing down. cell.com/cell-metabolis…

@wadein4u @RogerSeheult @mitogenia @niroshajmurugan Interesting work, indeed. There are over 12,000 papers on biophotons / Ultraweak Photon Emission. Quite a robust phenomenon.

@RogerSeheult @mitogenia @MitoPsychoBio @niroshajmurugan What?!? 🤯

🚨🚨A recent thesis about to be published by Ifigeneia Kalampouka, PhD @mitogenia - (worth following BTW) on biophotons and cellular senescence found that isolated senescent mitochondria did two very interesting things: 1) They directly emitted measurable ultraweak photons, and 2) Mitochondria in a separate, chemically isolated chamber showed different oxygen-consumption behavior when unshielded vs shielded. i.e. mitochondria talked to each other in different test tubes! That does NOT prove, in a final sense, that mitochondria are “communicating with light.” - yet. But it does show something real and intriguing: Stressed/senescent mitochondria appear to emit ultraweak light, and other physically isolated mitochondria behave differently when exposed to a non-chemical signal that is consistent with a light-based mechanism. This is early bench science, not bedside medicine. Still, if this holds up, it could open an entirely new way of thinking about mitochondrial signaling, oxidative stress, aging, and maybe even photobiomodulation. Really fascinating work. There's also a whole other section where NIR is used doi.org/10.34737/wy80y

@lavanyaachanta @seonggyung35911 I try to write daily between 6-8am. And use off/vacation time for longer stretches.

@MitoPsychoBio @seonggyung35911 A question for you @MitoPsychoBio, how do you find the time to write a book? Have you allocated time during the day to do so and what inspired you to write the book? I am curious.🧐

스트레스는 만병의 근원

Today in The Science and Experience of Energy, we discuss the best biomarker of aging, diseases, and mortality: the blood cytokine GDF15. GDF15 is a metabolically-regulated cytokine—known as a metabokine. Because it's elevated in numerous diseases and predicts poor health outcomes, the idea became that blocking it might be useful. For example, in cancer cachexia, GDF15 is associated with loss of appetite, weight loss, and mortality. So blocking it might make people eat more, lose less weight, and survive. The first clinical trial showed promising results around the appetite and weight loss, but worrying results around mortality. In this morning's post, Alan Cohen @cusciofhealth and I unpack this result and some of the psychobiology of GDF15. martinpicard.substack.com/p/could-blocki…

@jorgensenmc1 @chydorina Right on

This maps onto Martin Picards energy resistance principle. Also to the new papers showing depressed patients actually have high ATP but cant use it for higher order thinking , motivation etc. it just builds up causing damage and break down product adenosine causing sleep pressure perhaps. Doesnt ATP turn into a danger signal when leaking out into extracellular space triggering inflammation also ?

First mechanism behind the 'no choice naps' that I have been talking about for years that finally makes sense to me. The "no-choice" naps really are no choice - they are sudden completely unstoppable urges to sleep. For me they last 1-2 hours and I wake up feel horrible. I have tried to not fall asleep when this comes on but it is not possible - it really is like something is forcing an emergency shutdown.

@chydorina @jorgensenmc1 Yes, with @niroshajmurugan

@jorgensenmc1 yes! @MitoPsychoBio

@arijo @matiask_1988 Thank you for sharing.

@MitoPsychoBio @matiask_1988 I’ve tried running and weights many times but it seems to hurt more than it helps with my schizoaffective disorder. Keep researching Dr. Martin Picard - you’re on the right path to end a lot of suffering in this world.

Exercise is good for the brain. But why? This morning in The Science and Experience of Energy we explore the effects of exercise on brain mitochondrial. And why making more mitochondria might in part be why moving keeps our brain healthy. martinpicard.substack.com/p/mitochondria…

Beautiful mitochondria in your muscles 💪🏼

@AlisonbobEth @niroshajmurugan Thank you, Alison.

@MitoPsychoBio @niroshajmurugan You guys are doing great work ❤️

Feeling grateful to have been able to share with a growing community my love of mitochondria, and our vision for a healthier, more sustainable future where everyone can flourish. From Nirosha and I, and our team: Thank You! @niroshajmurugan martinpicard.substack.com/publish/post/1…

@ttrain4086 Physical play with your child, if you get out of breath, might count 😀 x.com/ttrain4086/sta…

@MitoPsychoBio how did you know i didn't work out today???

@WilliamFurness @Hakan_Atalay2 @conatus1632 @nicknorwitz @NTFabiano @Columbia Free formatted version available here picardlab.org/all-publicatio…

@Hakan_Atalay2 @conatus1632 @nicknorwitz @MitoPsychoBio @NTFabiano @Columbia Appreciate that. @MitoPsychoBio & McEwen (2018) in Psychosom Med, is the paper I'd start with. Would genuinely love to hear what you think. "Psychological Stress and Mitochondria: A Conceptual Framework." pmc.ncbi.nlm.nih.gov/articles/PMC59…

I've been saying this for a while. Now JAMA Psychiatry said it louder. 54 studies. 17,065 people. The real story of depression isn't in the monoamines... It's in the mitochondria. 🧵

@JHennche @WilliamFurness @nicknorwitz @NTFabiano @grok Would love to see data on the effect of a 72 hour fast on mitochondria. Many people report positive psychological and physiological changes with this.

@WilliamFurness @MitoPsychoBio @nicknorwitz @NTFabiano @grok 72h water fasts?

@LocasaleLab Good analysis.

This is an example of the rot inside Nature. This will be hyped and canonized as truth. Influencers will take over, and critical scientists will stay quiet or be left out of the conversation. The topic is trendy, so it gets published, and the tacit conclusions are far more grand than what the data support. They are essentially claiming to have found a genetic basis of GLP-1 response. In reality, this is a GWAS study. These studies rarely identify genes of real interest and have largely proven ineffectual in complex diseases, in part because these traits are multigenic and heavily influenced by environment. GWAS looks at single associations and says nothing about causality. At first glance, the effect size is not even reported in the abstract. And the p-value of the lead hit—near the GLP-1 locus—given a cohort of nearly 30,000, strongly suggests the effect is very small and not much overall came from this study just like most of the GWAS studies conducted over the past 15-20 years.

@travelingenes Looking forward to it, Grace! Thank you.

I made my first documentary at 17. I'm 20 now. I still fight imposter syndrome every single day, still wonder if i'm the right person to tell these stories. Yet I keep coming back to it. And I feel so grateful I even get to try. God has placed the most incredible people in my path. each of them has taught me something I didn't know I needed. My second film drops next week on youtube :)

@niroshajmurugan Life is so beautiful

Behold, the cochlea. A spiral of cells, tonotopically organized to represent frequency in space - tiny patches of tissue coding for temporal oscillations of energy that we eventually experience as tones, music & voices. And all of this happens in a space of about 30 millimeters. Fluorescent imaging credit: @Katelyn_Comeau